Short co-incubation of gametes combined with early rescue ICSI: An optimal strategy for complete fertilization failure after IVF

2013 ◽  
Vol 17 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Weiwei Liu ◽  
Junxia Liu ◽  
Xiaodong Zhang ◽  
Wei Han ◽  
Shun Xiong ◽  
...  
Keyword(s):  
Optimal Strategy ◽  
Fertilization Failure ◽  
Rescue Icsi

scholarly journals Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Alessio Paffoni ◽  
Marco Reschini ◽  
Valerio Pisaturo ◽  
Cristina Guarneri ◽  
Simone Palini ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Implantation Rate ◽  
Clinical Pregnancy ◽  
Frozen Embryo Transfer ◽  
Fertilization Failure ◽  
Vitro Fertilization ◽  
Rescue Icsi

Abstract Background Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasmic sperm injection (ICSI) has become the first choice over conventional in vitro fertilization (IVF) procedures although evidence of improved results is still debated and its use in couples without male factor infertility is not recommended. Among the strategies potentially useful to promote the use of conventional IVF, we herein call attention to the late rescue ICSI, which consists in performing ICSI after 18–24 h from conventional insemination on oocytes that show no signs of fertilization. This treatment has however been reported to be associated with a low success rate until recent observations that embryos derived from late rescue ICSI may be transferred after cryopreservation in a frozen-thawed cycle with improved results. The aim of the present study was to assess whether frozen embryos deriving from rescue ICSI performed about 24 h after conventional IVF may represent a valuable option for couples experiencing fertilization failure. Methods A systematic review on the efficacy of late rescue ICSI was performed consulting PUBMED and EMBASE. Results Including twenty-two original studies, we showed that clinical pregnancy rate per embryo transfer and implantation rate obtainable with fresh embryo transfers after rescue ICSI are not satisfactory being equal to 10 and 5%, respectively. The transfer of cryopreserved rescue ICSI embryos seems to offer a substantial improvement of success rates, with pregnancy rate per embryo transfer and implantation rate equal to 36 and 18%, respectively. Coupling rescue ICSI with frozen embryo transfer may ameliorate the clinical pregnancy rate for embryo transfer with an Odds Ratio = 4.7 (95% CI:2.6–8.6). Conclusion Results of the present review support the idea that r-ICSI coupled with frozen embryo transfer may overcome most of the technical and biological issues associated with fresh transfer after late r-ICSI, thus possibly representing an efficient procedure for couples experiencing fertilization failure following conventional IVF cycles. Trial registration Prospero registration ID: CRD42021239026.

scholarly journals Comparison of short and long co-incubation time of gametes for in vitro fertilization

2019 ◽  
Vol 8 (11) ◽  
pp. 4366
Author(s):  
Pallop Pongsuthirak
Keyword(s):  
In Vitro Fertilization ◽  
Incubation Time ◽  
Pregnancy Outcomes ◽  
Fertilization Failure ◽  
Vitro Fertilization ◽  
Group I ◽  
Significant Difference ◽  
Total Fertilization Failure ◽  
Rescue Icsi

Background: The short and long co-incubation time of gametes for in vitro fertilization are still debatable issues. This study aims to investigate the effects of short and long co-incubation time of gametes on fertilization, polyspermy, embryonic developmental potential, and clinical outcomes.Methods: Sixty-five patients undergoing IVF treatment were invited to participate in the study between May 2017 and March 2019. Ovarian hyperstimulation was prescribed and oocytes were obtained by trans-vaginal aspiration under ultrasound guidance. Sibling oocytes were randomly allocated to short co-incubation for 4 hours (Group I) in 352 oocytes and long co-incubation for 16-18 hours in 363 oocytes (Group II). Rescue ICSI was carried out if total fertilization failure was documented. Fertilization, embryonic development, and pregnancy outcomes were determined.Results: No significant differences between short and long co-incubation were found in fertilization, polyspermy, cleavage, blastocyst, implantation, clinical pregnancy, and live birth rates.Conclusions: The present study showed that short co-incubation of gametes had no significant difference in fertilization, polyspermy, embryo development, and pregnancy outcomes when compared to long co-incubation. The short co-incubation with early cumulus cell removal and rescue ICSI may have the potential to help a couple who had total fertilization failure.

“rescue” ICSI: saving a treatment cycle from fertilization failure

2013 ◽  
Vol 100 (3) ◽  
pp. S531
Author(s):  
D.A. Sheehan ◽  
J.C. Patel ◽  
S.A. Pauli ◽  
S.C. Pang ◽  
K.J. Go
Keyword(s):  
Treatment Cycle ◽  
Fertilization Failure ◽  
Rescue Icsi

P-111 Rescue ICSI is of benefit in cases of fertilization failure

1997 ◽  
Vol 68 ◽  
pp. S144
Author(s):  
D.T Carrell ◽  
B Campbell ◽  
P Kuneck ◽  
C.M Peterson ◽  
H.H Hatasaka ◽  
...  
Keyword(s):  
Fertilization Failure ◽  
Rescue Icsi

Automated Development of Clinical Strategies Using Multistage Decision Analysis

1986 ◽  
Vol 25 (04) ◽  
pp. 207-214 ◽  
Author(s):  
P. Glasziou
Keyword(s):  
Decision Tree ◽  
Decision Analysis ◽  
Decision Trees ◽  
Optimal Strategy ◽  
Cholestatic Jaundice ◽  
Clinical Strategies ◽  
Simultaneous Study

SummaryThe development of investigative strategies by decision analysis has been achieved by explicitly drawing the decision tree, either by hand or on computer. This paper discusses the feasibility of automatically generating and analysing decision trees from a description of the investigations and the treatment problem. The investigation of cholestatic jaundice is used to illustrate the technique.Methods to decrease the number of calculations required are presented. It is shown that this method makes practical the simultaneous study of at least half a dozen investigations. However, some new problems arise due to the possible complexity of the resulting optimal strategy. If protocol errors and delays due to testing are considered, simpler strategies become desirable. Generation and assessment of these simpler strategies are discussed with examples.

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