The role and amplification of the HS Alu subfamily founder gene

1996 ◽  
Vol 42 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Tamim H. Shaikh ◽  
Prescott L. Deininger
Keyword(s):  
Founder Gene

Retroposition in a family of carcinoma-associated antigen genes

1993 ◽  
Vol 13 (3) ◽  
pp. 1507-1515
Author(s):  
A J Linnenbach ◽  
B A Seng ◽  
S Wu ◽  
S Robbins ◽  
M Scollon ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cdna Sequence ◽  
Genomic Sequence ◽  
Chromosome Region ◽  
Cdna Probe ◽  
Type I ◽  
Promoter Regions ◽  
Gene Encoding ◽  
Intronless Gene ◽  
Founder Gene

The gene encoding the carcinoma-associated antigen defined by the monoclonal antibody GA733 is a member of a family of at least two type I membrane proteins. This study describes the mechanism of evolution of the GA733-1 and GA733-2 genes. A full-length cDNA clone for GA733-1 was obtained by screening a human placental library with a genomic DNA probe. Comparative analysis of the cDNA sequence with the previously determined genomic sequence confirmed that GA733-1 is an intronless gene. The GA733-2 gene encoding the monoclonal antibody-defined antigen was molecularly cloned with a cDNA probe and partially sequenced. Comparison of GA733-2 gene sequences with the previously established cDNA sequence revealed that this gene consists of nine exons. The putative promoter regions of the GA733-1 and GA733-2 genes are unrelated. These findings suggest that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. Prior to retroposition, the GA733-2 gene had been affected by exon shuffling. Analysis of GA733-2 exons revealed that many delineate structural motifs. The GA733-1 retroposon was localized either to chromosome region 1p32-1p31 or to 1p13-1q12, and the GA733-2 founder gene was localized to chromosome 4q.

scholarly journals Comparative Genetics and Evolution of Annexin A13 as the Founder Gene of Vertebrate Annexins

2002 ◽  
Vol 19 (5) ◽  
pp. 608-618 ◽  
Author(s):  
Juan-Manuel Iglesias ◽  
Reginald O. Morgan ◽  
Nancy A. Jenkins ◽  
Neal G. Copeland ◽  
Debra J. Gilbert ◽  
...  
Keyword(s):  
Comparative Genetics ◽  
Founder Gene

scholarly journals Evidence of a long QT founder gene with varying phenotypic expression in South African families.

1996 ◽  
Vol 33 (7) ◽  
pp. 567-573 ◽  
Author(s):  
T de Jager ◽  
C H Corbett ◽  
J C Badenhorst ◽  
P A Brink ◽  
V A Corfield
Keyword(s):  
South African ◽  
Phenotypic Expression ◽  
Long Qt ◽  
African Families ◽  
Founder Gene

scholarly journals Ant colony optimization based founder sequence reconstruction

2018 ◽  
Vol 33 (2) ◽  
Author(s):  
Anh Vu Thi Ngoc ◽  
Dinh Phuc Thai ◽  
Hoang Duc Nguyen ◽  
Thanh Hai Dang ◽  
Dong Do Duc
Keyword(s):  
Ant Colony Optimization ◽  
Evolutionary Biology ◽  
Optimization Problem ◽  
Gene Sequence ◽  
Ant Colony ◽  
Ant Colony Optimization Algorithm ◽  
Benchmark Datasets ◽  
Sequence Reconstruction ◽  
Test Sets ◽  
Founder Gene

Reconstruction of founder (ancestor) genes for a given population is an important problem in evolutionary biology. It involves finding a set of genes that can combine together to form genes of all individuals in that population. Such reconstruction can be modeled as a combinatorial optimization problem, in which we have to find a set of founder (gene) sequences so that the individuals in a given population can be generated by the smallest number of recombination on these founder sequences. In this paper we propose a novel ant colony optimization algorithm (ACO) based method, equipped with some important improvements, for the founder gene sequence reconstruction problem. The proposed method yields excellent performance when validating on 108 test sets from three benchmark datasets. Comparing with the best by far method for founder sequence reconstruction, our proposed method performs better in 45 test sets, equally well in 44 and worse only in 19 sets. These experimental results demonstrate the efficacy and perspective of our proposed method.

scholarly journals The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Blood ◽  
2016 ◽  
Vol 128 (25) ◽  
pp. 2960-2975 ◽  
Author(s):  
Ashley A. Basiorka ◽  
Kathy L. McGraw ◽  
Erika A. Eksioglu ◽  
Xianghong Chen ◽  
Joseph Johnson ◽  
...  
Keyword(s):  
Cell Death ◽  
Myelodysplastic Syndrome ◽  
Nlrp3 Inflammasome ◽  
Gene Mutations ◽  
Inflammasome Activation ◽  
Biological Features ◽  
Nlrp3 Inflammasome Activation ◽  
Key Points ◽  
Founder Gene

Key Points Key biological features of MDSs are explained by NLRP3 inflammasome activation, which drives pyroptotic cell death and β-catenin activation. Alarmin signals and founder gene mutations license this redox-sensitive inflammasome platform.

scholarly journals Retroposition in a family of carcinoma-associated antigen genes.

1993 ◽  
Vol 13 (3) ◽  
pp. 1507-1515 ◽  
Author(s):  
A J Linnenbach ◽  
B A Seng ◽  
S Wu ◽  
S Robbins ◽  
M Scollon ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cdna Sequence ◽  
Genomic Sequence ◽  
Chromosome Region ◽  
Cdna Probe ◽  
Type I ◽  
Promoter Regions ◽  
Gene Encoding ◽  
Intronless Gene ◽  
Founder Gene

The gene encoding the carcinoma-associated antigen defined by the monoclonal antibody GA733 is a member of a family of at least two type I membrane proteins. This study describes the mechanism of evolution of the GA733-1 and GA733-2 genes. A full-length cDNA clone for GA733-1 was obtained by screening a human placental library with a genomic DNA probe. Comparative analysis of the cDNA sequence with the previously determined genomic sequence confirmed that GA733-1 is an intronless gene. The GA733-2 gene encoding the monoclonal antibody-defined antigen was molecularly cloned with a cDNA probe and partially sequenced. Comparison of GA733-2 gene sequences with the previously established cDNA sequence revealed that this gene consists of nine exons. The putative promoter regions of the GA733-1 and GA733-2 genes are unrelated. These findings suggest that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. Prior to retroposition, the GA733-2 gene had been affected by exon shuffling. Analysis of GA733-2 exons revealed that many delineate structural motifs. The GA733-1 retroposon was localized either to chromosome region 1p32-1p31 or to 1p13-1q12, and the GA733-2 founder gene was localized to chromosome 4q.

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