scholarly journals The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Blood ◽  
2016 ◽  
Vol 128 (25) ◽  
pp. 2960-2975 ◽  
Author(s):  
Ashley A. Basiorka ◽  
Kathy L. McGraw ◽  
Erika A. Eksioglu ◽  
Xianghong Chen ◽  
Joseph Johnson ◽  
...  
Keyword(s):  
Cell Death ◽  
Myelodysplastic Syndrome ◽  
Nlrp3 Inflammasome ◽  
Gene Mutations ◽  
Inflammasome Activation ◽  
Biological Features ◽  
Nlrp3 Inflammasome Activation ◽  
Key Points ◽  
Founder Gene

Key Points Key biological features of MDSs are explained by NLRP3 inflammasome activation, which drives pyroptotic cell death and β-catenin activation. Alarmin signals and founder gene mutations license this redox-sensitive inflammasome platform.

scholarly journals Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

Blood ◽  
2016 ◽  
Vol 128 (17) ◽  
pp. 2153-2164 ◽  
Author(s):  
Shrey Kohli ◽  
Satish Ranjan ◽  
Juliane Hoffmann ◽  
Muhammed Kashif ◽  
Evelyn A. Daniel ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Nlrp3 Inflammasome ◽  
Purinergic Signaling ◽  
Atp Release ◽  
Inflammasome Activation ◽  
Trophoblast Cells ◽  
Nlrp3 Inflammasome Activation ◽  
Key Points

Key Points EVs cause accumulation of activated maternal platelets within the placenta, resulting in a thromboinflammatory response and PE. Activated maternal platelets cause NLRP3-inflammasome activation in trophoblast cells via ATP release and purinergic signaling.

scholarly journals IRF8 Regulates Gram-Negative Bacteria–Mediated NLRP3 Inflammasome Activation and Cell Death

2020 ◽  
Vol 204 (9) ◽  
pp. 2514-2522 ◽  
Author(s):  
Rajendra Karki ◽  
Ein Lee ◽  
Bhesh R. Sharma ◽  
Balaji Banoth ◽  
Thirumala-Devi Kanneganti
Keyword(s):  
Cell Death ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Nlrp3 Inflammasome Activation

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

Blood ◽  
2013 ◽  
Vol 122 (20) ◽  
pp. 3473-3481 ◽  
Author(s):  
Elham Asgari ◽  
Gaelle Le Friec ◽  
Hidekazu Yamamoto ◽  
Esperanza Perucha ◽  
Steven S. Sacks ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Human Monocytes ◽  
Nlrp3 Inflammasome Activation ◽  
Key Points ◽  
Activated Monocytes ◽  
Atp Efflux

Key Points C3aR activation increases ATP efflux, NLRP3 inflammasome activation, and IL-1β secretion in human monocytes. C3aR-activated monocytes drive Th17 responses in vitro and likely in vivo.

scholarly journals Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

Blood ◽  
2013 ◽  
Vol 122 (20) ◽  
pp. 3405-3414 ◽  
Author(s):  
Eugenio D. Hottz ◽  
Juliana F. Lopes ◽  
Carla Freitas ◽  
Rogério Valls-de-Souza ◽  
Marcus F. Oliveira ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Vascular Permeability ◽  
Nlrp3 Inflammasome ◽  
Dengue Infection ◽  
Inflammasome Activation ◽  
Dengue Virus Infection ◽  
Nlrp3 Inflammasome Activation ◽  
Key Points ◽  
Endothelium Permeability

Key Points Dengue infection triggers functional inflammasome assembly in platelets. Platelets may contribute to increased vascular permeability in dengue virus infection by synthesis and release of IL-1β.

scholarly journals ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease

2020 ◽  
Vol 217 (7) ◽  
Author(s):  
Sannula Kesavardhana ◽  
Thirumala-Devi Kanneganti
Keyword(s):  
Cell Death ◽  
Nucleic Acids ◽  
Inflammatory Disease ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Specific Ligand

ZBP1 triggers NLRP3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous. Recent studies, including Devos et al. in this issue of JEM (https://doi.org/10.1084/jem.20191913), collectively suggest that ZBP1 sensing Z-nucleic acids is critical for cell death/inflammatory disease.

scholarly journals NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

2016 ◽  
Vol 25 (8) ◽  
pp. 1501-1516 ◽  
Author(s):  
Ishaq A. Viringipurampeer ◽  
Andrew L. Metcalfe ◽  
Abu E. Bashar ◽  
Olena Sivak ◽  
Anat Yanai ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Degeneration ◽  
Nlrp3 Inflammasome ◽  
Photoreceptor Cell ◽  
Inflammasome Activation ◽  
Cone Photoreceptor ◽  
Nlrp3 Inflammasome Activation

scholarly journals Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release

2017 ◽  
Vol 8 (8) ◽  
pp. e2984-e2984 ◽  
Author(s):  
Fátima Martín-Sánchez ◽  
Juan José Martínez-García ◽  
María Muñoz-García ◽  
Miriam Martínez-Villanueva ◽  
José A Noguera-Velasco ◽  
...  
Keyword(s):  
Cell Death ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation
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