aspartyl proteases

2020 ◽  
Author(s):  
P.S. Sears
Keyword(s):  
Aspartyl Proteases

scholarly journals Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases

2018 ◽  
Vol 37 (7) ◽  
Author(s):  
Budhaditya Mukherjee ◽  
Francesca Tessaro ◽  
Juha Vahokoski ◽  
Inari Kursula ◽  
Jean‐Baptiste Marq ◽  
...  
Keyword(s):  
Aspartyl Proteases

Aspartyl proteases from the intestinal brush border of Haemonchus contortus as protective antigens for sheep

2003 ◽  
Vol 25 (11-12) ◽  
pp. 521-530 ◽  
Author(s):  
W. D. Smith ◽  
P. J. Skuce ◽  
G. F. J. Newlands ◽  
S. K. Smith ◽  
D. Pettit
Keyword(s):  
Brush Border ◽  
Haemonchus Contortus ◽  
Protective Antigens ◽  
Intestinal Brush Border ◽  
Aspartyl Proteases

scholarly journals A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata

2007 ◽  
Vol 104 (18) ◽  
pp. 7628-7633 ◽  
Author(s):  
Rupinder Kaur ◽  
Biao Ma ◽  
Brendan P. Cormack
Keyword(s):  
Cell Wall ◽  
Mammalian Cells ◽  
Candida Glabrata ◽  
Global Changes ◽  
Cell Wall Proteins ◽  
Culture Model ◽  
Genes Encoding ◽  
Tissue Culture Model ◽  
A Cell ◽  
Aspartyl Proteases

Candida glabrata is a yeast pathogen of humans. We have established a tissue culture model to analyze the interaction of C. glabrata with macrophages. Transcript profiling of yeast ingested by macrophages reveals global changes in metabolism as well as increased expression of a gene family (YPS genes) encoding extracellular glycosylphosphatidylinositol-linked aspartyl proteases. Eight of these YPS genes are found in a cluster that is unique to C. glabrata. Genetic analysis shows that the C. glabrata YPS genes are required for cell wall integrity, adherence to mammalian cells, survival in macrophages and virulence. By monitoring the processing of a cell wall adhesin, Epa1, we also show that Yps proteases play an important role in cell wall re-modeling by removal and release of glycosylphosphatidylinositol-anchored cell wall proteins.

Trypanosoma cruzi: Isolation and characterization of aspartyl proteases

2009 ◽  
Vol 122 (2) ◽  
pp. 128-133 ◽  
Author(s):  
Rosa T. Pinho ◽  
Leila M. Beltramini ◽  
Carlos R. Alves ◽  
Salvatore G. De-Simone
Keyword(s):  
Trypanosoma Cruzi ◽  
Isolation And Characterization ◽  
Aspartyl Proteases

P4-272 Presenilin-related putative intramembrane aspartyl-proteases

2004 ◽  
Vol 25 ◽  
pp. S553
Author(s):  
Evgeny I. Rogaev ◽  
Yuri K. Moliaka ◽  
Anastasia Grigorenko
Keyword(s):  
Aspartyl Proteases

scholarly journals BACE1 and Presenilin: Two Unusual Aspartyl Proteases Involved in Alzheimer’s Disease

2004 ◽  
Vol 1 (4-5) ◽  
pp. 168-174 ◽  
Author(s):  
Diana-Ines Dominguez ◽  
Dieter Hartmann ◽  
Bart De Strooper
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Aspartyl Proteases

scholarly journals From L-Ascorbic Acid to Protease Inhibitors: Practical Synthesis of Key Chiral Epoxide Intermediates for Aspartyl Proteases

2012 ◽  
Vol 33 (7) ◽  
pp. 2213-2218 ◽  
Author(s):  
Sun-Ki Chang ◽  
Soon-Mog So ◽  
Sang-Min Lee ◽  
Min-Kyu Kim ◽  
Kyoung-Mee Seol ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Protease Inhibitors ◽  
Practical Synthesis ◽  
Aspartyl Proteases
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