scholarly journals Conjugated Polymer Nanoparticles toward In Vivo Theranostics - Focus on Targeting, Imaging, Therapy, and the Importance of Clearance

2017 ◽  
Vol 1 (11) ◽  
pp. 1700100 ◽  
Author(s):  
Alexander J. C. Kuehne
Keyword(s):  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

scholarly journals Impairing Proliferation of Glioblastoma Multiforme with CD44+ Selective Conjugated Polymer Nanoparticles

2021 ◽  
Author(s):  
Dorota Lubanska ◽  
Sami Alrashed ◽  
Gage T. Mason ◽  
Fatima Nadeem ◽  
Mitchell DiPasquale ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Conjugated Polymer ◽  
Average Diameter ◽  
Polymer Nanoparticles ◽  
Brain Barrier ◽  
Cycle Phase ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Conjugated Polymer Nanoparticles

Glioblastoma is one of the most aggressive types of cancer with median survival of only 15 months. Successful therapy is hampered by the existence of treatment resistant populations of stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable of effectively targeting the TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) with an average diameter of 109 nm. The CPN were designed to include fluorescein-conjugated hyaluronic acid (HA), a ligand for the CD44 receptor present on one population of TICs. We demonstrate blood-brain barrier permeability of this system and concentration and cell cycle phase-dependent selective uptake of HA-CPNs in CD44 positive GBM-patient derived cultures. Interestingly, we found that uptake alone decreases stemness, invasive properties and proliferation of the CD44-TIC population in zebrafish PDX models in vivo. This study is the first to show surface moiety-driven selectivity of conjugated polymer nanoparticles in targeting TIC populations in brain cancer.

scholarly journals Fluorescence Imaging: Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging (Small 18/2013)

Small ◽  
2013 ◽  
Vol 9 (18) ◽  
pp. 3092-3092 ◽  
Author(s):  
Dan Ding ◽  
Jie Liu ◽  
Guangxue Feng ◽  
Kai Li ◽  
Yong Hu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Conjugated polymer nanoparticles for biomedical in vivo imaging

2010 ◽  
Vol 46 (10) ◽  
pp. 1617 ◽  
Author(s):  
Sehoon Kim ◽  
Chang-Keun Lim ◽  
Jinhee Na ◽  
Yong-Deok Lee ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

scholarly journals Fluorescent Multiblock π-Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting

2013 ◽  
Vol 25 (32) ◽  
pp. 4504-4510 ◽  
Author(s):  
Eilaf Ahmed ◽  
Stephen W. Morton ◽  
Paula T. Hammond ◽  
Timothy M. Swager
Keyword(s):  
Conjugated Polymer ◽  
Tumor Targeting ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging

Small ◽  
2013 ◽  
Vol 9 (18) ◽  
pp. 3093-3102 ◽  
Author(s):  
Dan Ding ◽  
Jie Liu ◽  
Guangxue Feng ◽  
Kai Li ◽  
Yong Hu ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

AIE-active conjugated polymer nanoparticles with red-emission for in vitro and in vivo imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114580-114586 ◽  
Author(s):  
Dongliang Yang ◽  
Shuwei Zhang ◽  
Yanling Hu ◽  
Jia Chen ◽  
Biqing Bao ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Conjugated Polymer ◽  
Fluorescence Emission ◽  
Polymer Nanoparticles ◽  
Red Emission ◽  
Bright Fluorescence ◽  
Conjugated Polymer Nanoparticles ◽  
Excellent Photostability

Novel AIE-active conjugated polymer nanoparticles with bright fluorescence emission and excellent photostability have been prepared for imaging in cells and zebrafish.

scholarly journals Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1258
Author(s):  
N. Arias-Ramos ◽  
L. E. Ibarra ◽  
M. Serrano-Torres ◽  
B. Yagüe ◽  
M. D. Caverzán ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Conjugated Polymer ◽  
Colloidal Stability ◽  
Fluorescent Imaging ◽  
Polymer Nanoparticles ◽  
Biodistribution Studies ◽  
Conjugated Polymer Nanoparticles ◽  
Theranostic Agents

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functionalization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3O4 and NiFe2O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.

scholarly journals Impairing Proliferation of Glioblastoma Multiforme with CD44+ Selective Conjugated Polymer Nanoparticles

2021 ◽  
Author(s):  
Dorota Lubanska ◽  
Sami Alrashed ◽  
Gage T. Mason ◽  
Fatima Nadeem ◽  
Mitchell DiPasquale ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Conjugated Polymer ◽  
Average Diameter ◽  
Polymer Nanoparticles ◽  
Brain Barrier ◽  
Cycle Phase ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Conjugated Polymer Nanoparticles

Glioblastoma is one of the most aggressive types of cancer with median survival of only 15 months. Successful therapy is hampered by the existence of treatment resistant populations of stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable of effectively targeting the TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) with an average diameter of 109 nm. The CPN were designed to include fluorescein-conjugated hyaluronic acid (HA), a ligand for the CD44 receptor present on one population of TICs. We demonstrate blood-brain barrier permeability of this system and concentration and cell cycle phase-dependent selective uptake of HA-CPNs in CD44 positive GBM-patient derived cultures. Interestingly, we found that uptake alone decreases stemness, invasive properties and proliferation of the CD44-TIC population in zebrafish PDX models in vivo. This study is the first to show surface moiety-driven selectivity of conjugated polymer nanoparticles in targeting TIC populations in brain cancer.

Bis-diketopyrrolopyrrole conjugated polymer nanoparticles as photothermic nanoagonist for specific and synergistic glioblastoma therapy

Biomaterials ◽  
2019 ◽  
Vol 216 ◽  
pp. 119252 ◽  
Author(s):  
Shengliang Li ◽  
Qingyuan Deng ◽  
Xiao Li ◽  
Yongwei Huang ◽  
Xiaozhen Li ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles
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