Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging

Small ◽  
2013 ◽  
Vol 9 (18) ◽  
pp. 3093-3102 ◽  
Author(s):  
Dan Ding ◽  
Jie Liu ◽  
Guangxue Feng ◽  
Kai Li ◽  
Yong Hu ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

scholarly journals Fluorescence Imaging: Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging (Small 18/2013)

Small ◽  
2013 ◽  
Vol 9 (18) ◽  
pp. 3092-3092 ◽  
Author(s):  
Dan Ding ◽  
Jie Liu ◽  
Guangxue Feng ◽  
Kai Li ◽  
Yong Hu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Theranostic Near-Infrared-Active Conjugated Polymer Nanoparticles

ACS Nano ◽  
2021 ◽  
Author(s):  
Miao Zhao ◽  
Edward Leggett ◽  
Struan Bourke ◽  
Souzana Poursanidou ◽  
Sadie Carter-Searjeant ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications

2015 ◽  
Vol 6 (21) ◽  
pp. 3962-3969 ◽  
Author(s):  
Chunhui Dai ◽  
Dongliang Yang ◽  
Wenjie Zhang ◽  
Biqing Bao ◽  
Yixiang Cheng ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Cell Imaging ◽  
Polymer Nanoparticles ◽  
Size Dependent ◽  
Conjugated Polymer Nanoparticles ◽  
Nanoparticle Sizes

We prepared a series of novel chiral far-red/near-infrared fluorescent CPNs with different nanoparticle sizes, which show size-dependent chirality and are successfully employed for cell imaging.

scholarly journals Impairing Proliferation of Glioblastoma Multiforme with CD44+ Selective Conjugated Polymer Nanoparticles

2021 ◽  
Author(s):  
Dorota Lubanska ◽  
Sami Alrashed ◽  
Gage T. Mason ◽  
Fatima Nadeem ◽  
Mitchell DiPasquale ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Conjugated Polymer ◽  
Average Diameter ◽  
Polymer Nanoparticles ◽  
Brain Barrier ◽  
Cycle Phase ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Conjugated Polymer Nanoparticles

Glioblastoma is one of the most aggressive types of cancer with median survival of only 15 months. Successful therapy is hampered by the existence of treatment resistant populations of stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable of effectively targeting the TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) with an average diameter of 109 nm. The CPN were designed to include fluorescein-conjugated hyaluronic acid (HA), a ligand for the CD44 receptor present on one population of TICs. We demonstrate blood-brain barrier permeability of this system and concentration and cell cycle phase-dependent selective uptake of HA-CPNs in CD44 positive GBM-patient derived cultures. Interestingly, we found that uptake alone decreases stemness, invasive properties and proliferation of the CD44-TIC population in zebrafish PDX models in vivo. This study is the first to show surface moiety-driven selectivity of conjugated polymer nanoparticles in targeting TIC populations in brain cancer.

Near-Infrared-Absorbing Conjugated Polymer Nanoparticles Loaded with Doxorubicin for Combinatorial Photothermal-Chemotherapy of Cancer

2020 ◽  
Vol 2 (10) ◽  
pp. 4180-4187
Author(s):  
Wei Zhang ◽  
Yi Li ◽  
Lanju Xu ◽  
Dou Wang ◽  
Jing Long ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Conjugated polymer nanoparticles for biomedical in vivo imaging

2010 ◽  
Vol 46 (10) ◽  
pp. 1617 ◽  
Author(s):  
Sehoon Kim ◽  
Chang-Keun Lim ◽  
Jinhee Na ◽  
Yong-Deok Lee ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

scholarly journals Fluorescent Multiblock π-Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting

2013 ◽  
Vol 25 (32) ◽  
pp. 4504-4510 ◽  
Author(s):  
Eilaf Ahmed ◽  
Stephen W. Morton ◽  
Paula T. Hammond ◽  
Timothy M. Swager
Keyword(s):  
Conjugated Polymer ◽  
Tumor Targeting ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles
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