Efficient Red/Near-Infrared Fluorophores Based on Benzo[1,2-b :4,5-b ′]dithiophene 1,1,5,5-Tetraoxide for Targeted Photodynamic Therapy and In Vivo Two-Photon Fluorescence Bioimaging

2018 ◽  
Vol 28 (13) ◽  
pp. 1706945 ◽  
Author(s):  
Shijie Zhen ◽  
Shaowei Wang ◽  
Shiwu Li ◽  
Wenwen Luo ◽  
Meng Gao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Two Photon ◽  
Fluorescence Bioimaging ◽  
Targeted Photodynamic Therapy ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescent imaging

2021 ◽  
Author(s):  
Ruiyuan Liu ◽  
Yuping Zhou ◽  
Di Zhang ◽  
Genghan He ◽  
Chuang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
High Fidelity ◽  
Design And Synthesis ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Design and synthesis of near-infrared (NIR) emissive fluorophore for imaging of organelle and photodynamic therapy has received enormous attention. Hence, NIR emissive fluorophore of high-fidelity lysosome targeting, two-photon fluorescence imaging,...

A lysosome-targeted near-infrared photosensitizer for photodynamic therapy and two-photon fluorescence imaging

2021 ◽  
Author(s):  
Yinuo Tu ◽  
Weikang Xia ◽  
Xu Wu ◽  
Lei Wang
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Organelle-targeted two-photon near-infrared photosensitizers are highly desirable for photodynamic therapy (PDT) of cancer. Herein, in this contribution, we have developed a 2-dicyanomethylenethiazole based D-π-A structured near-infrared photosensitizer (TTR). TTR depicts...

Near-infrared emissive carbon dots for two-photon fluorescence bioimaging

Nanoscale ◽  
2016 ◽  
Vol 8 (39) ◽  
pp. 17350-17356 ◽  
Author(s):  
Lulu Pan ◽  
Shan Sun ◽  
Ling Zhang ◽  
Kai Jiang ◽  
Hengwei Lin
Keyword(s):  
Carbon Dots ◽  
Near Infrared ◽  
Two Photon ◽  
Fluorescence Bioimaging ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Silole-Based Red Fluorescent Organic Dots for Bright Two-Photon Fluorescence In vitro Cell and In vivo Blood Vessel Imaging

Small ◽  
2015 ◽  
Vol 12 (6) ◽  
pp. 782-792 ◽  
Author(s):  
Bin Chen ◽  
Guangxue Feng ◽  
Bairong He ◽  
Chiching Goh ◽  
Shidang Xu ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Two Photon ◽  
Vessel Imaging ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

scholarly journals Two-Photon Microscopy Allows Imaging and Characterization of Cochlear Microvasculature In Vivo

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Friedrich Ihler ◽  
Mattis Bertlich ◽  
Bernhard Weiss ◽  
Steffen Dietzel ◽  
Martin Canis
Keyword(s):  
Fluorescence Microscopy ◽  
Inner Ear ◽  
Ex Vivo ◽  
Small Scale ◽  
Published Data ◽  
Cochlear Blood Flow ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Impairment of cochlear blood flow has been discussed as factor in the pathophysiology of various inner ear disorders. However, the microscopic study of cochlear microcirculation is limited due to small scale and anatomical constraints. Here, two-photon fluorescence microscopy is applied to visualize cochlear microvessels. Guinea pigs were injected with Fluorescein isothiocyanate- or Texas red-dextrane as plasma marker. Intravital microscopy was performed in four animals and explanted cochleae from four animals were studied. The vascular architecture of the cochlea was visualized up to a depth of90.0±22.7 μm. Imaging yielded a mean contrast-to-noise ratio (CNR) of3.3±1.7. Mean diameter in vivo was16.5±6.0 μm for arterioles and8.0±2.4 μm for capillaries. In explanted cochleae, the diameter of radiating arterioles and capillaries was measured with12.2±1.6 μm and6.6±1.0 μm, respectively. The difference between capillaries and arterioles was statistically significant in both experimental setups (P<0.001andP=0.022, two-way ANOVA). Measured vessel diameters in vivo and ex vivo were in agreement with published data. We conclude that two-photon fluorescence microscopy allows the investigation of cochlear microvessels and is potentially a valuable tool for inner ear research.

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