scholarly journals Biomolecular Materials: Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo (Adv. Mater. 28/2012)

2012 ◽  
Vol 24 (28) ◽  
pp. 3709-3709
Author(s):  
Matthew Black ◽  
Amanda Trent ◽  
Yulia Kostenko ◽  
Joseph Saeyong Lee ◽  
Colleen Olive ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Epitope ◽  
Protective Immune Response ◽  
Cytotoxic T Cell ◽  
T Cell Epitope ◽  
Peptide Amphiphile ◽  
Self Assembled

Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo

2012 ◽  
Vol 24 (28) ◽  
pp. 3845-3849 ◽  
Author(s):  
Matthew Black ◽  
Amanda Trent ◽  
Yulia Kostenko ◽  
Joseph Saeyong Lee ◽  
Colleen Olive ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Epitope ◽  
Protective Immune Response ◽  
Cytotoxic T Cell ◽  
T Cell Epitope ◽  
Peptide Amphiphile ◽  
Self Assembled

scholarly journals A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM)

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Tobias Cohen ◽  
Leonard Moise ◽  
Matthew Ardito ◽  
William Martin ◽  
Anne S. De Groot
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Epitope ◽  
Protein Therapeutics ◽  
T Cell Response ◽  
In Vivo Studies ◽  
T Cell Epitope ◽  
Hla Binding

The promise of pharmacogenomics depends on advancing predictive medicine. To address this need in the area of immunology, we developed the individualized T cell epitope measure (iTEM) tool to estimate an individual's T cell response to a protein antigen based on HLA binding predictions. In this study, we validated prospective iTEM predictions using data from in vitro and in vivo studies. We used a mathematical formula that convertsDRB1∗allele binding predictions generated by EpiMatrix, an epitope-mapping tool, into an allele-specific scoring system. We then demonstrated that iTEM can be used to define an HLA binding threshold above which immune response is likely and below which immune response is likely to be absent. iTEM's predictive power was strongest when the immune response is focused, such as in subunit vaccination and administration of protein therapeutics. iTEM may be a useful tool for clinical trial design and preclinical evaluation of vaccines and protein therapeutics.

scholarly journals CpG-DNA Activates In Vivo T Cell Epitope Presenting Dendritic Cells to Trigger Protective Antiviral Cytotoxic T Cell Responses

2000 ◽  
Vol 164 (5) ◽  
pp. 2372-2378 ◽  
Author(s):  
Ramunas M. Vabulas ◽  
Hanspeter Pircher ◽  
Grayson B. Lipford ◽  
Hans Häcker ◽  
Hermann Wagner
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Epitope ◽  
T Cell Responses ◽  
Cytotoxic T Cell ◽  
T Cell Epitope ◽  
Cpg Dna ◽  
Cell Responses ◽  
Cytotoxic T Cell Responses

scholarly journals Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo.

1996 ◽  
Vol 93 (22) ◽  
pp. 12531-12534 ◽  
Author(s):  
J. D. Ballard ◽  
R. J. Collier ◽  
M. N. Starnbach
Keyword(s):  
T Cell ◽  
Cell Epitope ◽  
Anthrax Toxin ◽  
Cytotoxic T Cell ◽  
T Cell Epitope

scholarly journals Identification of an MSI-H Tumor-Specific Cytotoxic T Cell Epitope Generated by the (−1) Frame ofU79260(FTO)

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Michael Linnebacher ◽  
Anne Wienck ◽  
Inga Boeck ◽  
Ernst Klar
Keyword(s):  
T Cell ◽  
Dna Sequences ◽  
Immune Surveillance ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
Repair System ◽  
T Cell Epitope ◽  
Reading Frame ◽  
Dna Mismatch ◽  
Dna Mismatch Repair System

Microsatellite instability (MSI-H) induced by defects of the DNA mismatch repair system results in insertion or deletion of single nucleotides at short repetitive DNA sequences. About 15% of sporadic and approximately 90% of hereditary nonpolyposis colorectal cancers display MSI-H. When affecting coding regions, MSI-H results in frameshift mutations and expression of corresponding frameshift peptides (FSPs). Functional tumor promoting relevance has been demonstrated for a growing number of genes frequently hit by MSI-H. Contrary, immune reactions against FSPs are involved in the immune surveillance of MSI-H cancers. Here, we provide conclusive data that the (−1) frame ofU79260(FTO)encodes an HLA-A0201-restricted cytotoxic T cell epitope (FSP11; TLSPGWSAV). T cells specific for FSP11 efficiently recognized HLA-A0201(pos)tumor cells harboring the mutated reading frame. Considering the exceptionally high mutation rate ofU79260(FTO)in MSI-H colorectal carcinoma (81.8%), this recommends that FSP11 be a component of future vaccines.

scholarly journals Identification of the immunodominant cytotoxic T-cell epitope of human -1 antitrypsin

Gene Therapy ◽  
2009 ◽  
Vol 16 (11) ◽  
pp. 1380-1382 ◽  
Author(s):  
E Breous ◽  
S Somanathan ◽  
J M Wilson
Keyword(s):  
T Cell ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
T Cell Epitope
Sign in / Sign up

Export Citation Format

Share Document