scholarly journals Influence of somatic mutations and pretransplant strategies in patients allografted for myelodysplastic syndrome or secondary acute myeloid leukemia

2020 ◽  
Vol 96 (1) ◽  
Author(s):  
Christina Rautenberg ◽  
Ulrich Germing ◽  
Stefanie Stepanow ◽  
Michael Lauseker ◽  
Karl Köhrer ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Somatic Mutations ◽  
Secondary Acute Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Takahiro Kumode ◽  
Ayano Fukui ◽  
Go Eguchi ◽  
Terufumi Yamaguchi ◽  
Yasuhiro Maeda
Keyword(s):  
Acute Myeloid Leukemia ◽  
Elderly Patients ◽  
Myelodysplastic Syndrome ◽  
Physical Condition ◽  
Myeloid Leukemia ◽  
Therapeutic Option ◽  
Tumor Burden ◽  
Secondary Leukemia ◽  
Secondary Acute Myeloid Leukemia ◽  
Acute Myeloid

Elderly patients with secondary acute myeloid leukemia (AML) following myelodysplastic syndrome (MDS) are often medically unfit for or resistant to chemotherapy, and their prognosis is dismal. In the present paper, we reported a case of secondary leukemia following MDS in an 80-year-old male patient who was deemed unfit for chemotherapy owing to his old age and poor physical condition. Despite a high tumor burden, treatment with AZA exerted a remarkable response, leading to an immediate cytoreduction in our case. Our results suggest that AZA can be an attractive therapeutic option for elderly MDS or AML patients, offering adequate efficacy and high tolerability.

Sign in / Sign up

Export Citation Format

Share Document