Heparin-mediated neutralization of platelet antiaggregatory activity of prostacyclin (PGI2): Studies on mechanism

1985 ◽  
Vol 20 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Sabiha R. Saba ◽  
Hussain I. Saba
Keyword(s):  
Antiaggregatory Activity

Stability of Prostacyclin in Human Plasma and Whole Blood: Studies on the Protective Effect of Albumin

1981 ◽  
Vol 46 (03) ◽  
pp. 645-647 ◽  
Author(s):  
M A Orchard ◽  
C Robinson
Keyword(s):  
Platelet Aggregation ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Protective Effect ◽  
Whole Blood ◽  
Bovine Serum ◽  
Fatty Acid Content ◽  
Krebs Solution ◽  
Antiaggregatory Activity ◽  
Free Plasma

SummaryThe biological half-life of prostacyclin in Krebs solution, human cell-free plasma or whole blood was measured by bracket assay on ADP-induced platelet aggregation. At 37°C, pH 7.4, plasma and blood reduced the rate of loss of antiaggregatory activity compared with Krebs solution. The protective effect of plasma was greater than that of whole blood. This effect could be partially mimicked by the addition of human or bovine serum albumin to the Krebs solution. The stabilisation afforded by human serum albumin was dependent on the fatty acid content of the albumin, although this was less important for bovine serum albumin.

scholarly journals INFLUENCE OF A PULSE MAGNETIC FIELD OF HIGH VOLTAGE ON THE INDICATORS OF ANTI-AGGREGATION ACTIVITY OF THE CHEMICAL SUBSTANCE AND THE PREPARED PHARMACY PREPARATION PENTOXYPLIN

2021 ◽  
Vol 23 (4) ◽  
pp. 45-50
Author(s):  
I.A. Belyaeva ◽  
◽  
L.I. Bashirova ◽  
V.A. Glushchenkov ◽  
N.A. Rodenko ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Pulse Magnetic Field ◽  
Pharmaceutical Preparation ◽  
Chemical Substance ◽  
Pure Substance ◽  
Effect Of Impurities ◽  
One Step ◽  
Biological Effectiveness ◽  
Antiaggregatory Activity ◽  
Aggregation Activity

It was found that the pharmaceutical preparation of pentoxifylline, treated with a pulsed magnetic field (PMF), changes the antiaggregatory properties.The pharmaceutical preparation contains the pure substance of pentoxifylline and a number of excipients. To understand the mechanism of changes in the antiaggregatory activity of a pharmaceutical preparation, the goal was to further investigate the effect of PMF parameters on its chemically pure substance.PMF processing was carried out on the «MIU Bio» installation with a single exposure at a field strength in the range (0.48–1.17) 106 A/m at discharge circuit frequencies (8–50) 103 Hz.Experiments have shown that the effect of PMF on the pure substance of pentoxifylline did not cause significant changes in its antiaggregatory activity. This result made it possible to get one step closer to understanding the mechanism of the effect of PMF on a given drug. Apparently, the reason for the change in the biological effectiveness of the pharmaceutical pentoxifylline treated with PMF lies in the effect of impurities, which will be the focus of further research.

Platelet-vessel wall interactions: Effects of platelets and plasma on the antiaggregatory activity and 6 keto-PGF1α production in isolated perfused aortas

1981 ◽  
Vol 22 (5) ◽  
pp. 703-713 ◽  
Author(s):  
C. Galli ◽  
A. Petroni ◽  
A. Socini ◽  
E. Agradi ◽  
C. Colombo ◽  
...  
Keyword(s):  
Vessel Wall ◽  
Antiaggregatory Activity ◽  
Wall Interactions

Platelet Antiaggregatory Activity of Normal Placentae: Conversion of ADP to Adenosine

1982 ◽  
Vol 63 (3) ◽  
pp. 75P-76P
Author(s):  
M. Barradas ◽  
M.A. Khokher ◽  
R.A. Hutton ◽  
I.L. Craft ◽  
P. Dandona
Keyword(s):  
Antiaggregatory Activity

Lipid Fractions with Aggregatory and Antiaggregatory Activity toward Platelets in Fresh and Fried Cod (Gadus morhua):  Correlation with Platelet-Activating Factor and Atherogenesis

2000 ◽  
Vol 48 (12) ◽  
pp. 6372-6379 ◽  
Author(s):  
Athina Panayiotou ◽  
Dimitris Samartzis ◽  
Tzortzis Nomikos ◽  
Elizabeth Fragopoulou ◽  
Haralabos C. Karantonis ◽  
...  
Keyword(s):  
Gadus Morhua ◽  
Platelet Activating Factor ◽  
Lipid Fractions ◽  
Antiaggregatory Activity

Comparative antiaggregatory activity in human platelets of a benzopyranone aci-reductone, clofibric acid, and a 2,3-dihydrobenzofuran analog

1986 ◽  
Vol 29 (11) ◽  
pp. 2170-2174 ◽  
Author(s):  
Donald T. Witiak ◽  
Sung K. Kim ◽  
Karl Romstedt ◽  
Howard A. I. Newman ◽  
Dennis R. Feller
Keyword(s):  
Human Platelets ◽  
Clofibric Acid ◽  
Antiaggregatory Activity
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