Genome-wide linkage analysis for celiac disease in North American families

2002 ◽  
Vol 111 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Susan L. Neuhausen ◽  
Mike Feolo ◽  
Nicola J. Camp ◽  
James Farnham ◽  
Linda Book ◽  
...  
2006 ◽  
Vol 8 (2) ◽  
pp. 108-114 ◽  
Author(s):  
C P Garner ◽  
Y C Ding ◽  
L Steele ◽  
L Book ◽  
K Leiferman ◽  
...  

2001 ◽  
Vol 9 (12) ◽  
pp. 938-944 ◽  
Author(s):  
Åsa Torinsson Naluai ◽  
Staffan Nilsson ◽  
Audur H Gudjónsdóttir ◽  
Andrew S Louka ◽  
Henry Ascher ◽  
...  

2001 ◽  
Vol 2 (1) ◽  
Author(s):  
Susan L Neuhausen ◽  
Michael Feolo ◽  
James Farnham ◽  
Linda Book ◽  
John J Zone

2017 ◽  
Vol 43 (4) ◽  
pp. 483 ◽  
Author(s):  
Kai LIU ◽  
Zhi-Ying DENG ◽  
Ying ZHANG ◽  
Fang-Fang WANG ◽  
Tong-Tong LIU ◽  
...  

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jia Y. Wan ◽  
Deborah L. Goodman ◽  
Emileigh L. Willems ◽  
Alexis R. Freedland ◽  
Trina M. Norden-Krichmar ◽  
...  

Abstract Background To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups. Methods Data was collected from GENetics of Noninsulin dependent Diabetes Mellitus (GENNID), a multiethnic resource of Type 2 diabetic families and included 1520 subjects in 259 African-American, European-American, Japanese-Americans, and Mexican-American families. We focused on eight MetS traits: weight, waist circumference, systolic and diastolic blood pressure, high-density lipoprotein, triglycerides, fasting glucose, and insulin. Using genotyped and imputed data from Illumina’s Multiethnic array, we conducted genome-wide association analyses with linear mixed models for all ethnicities, except for the smaller Japanese-American group, where we used additive genetic models with gene-dropping. Results Findings included ethnic-specific genetic associations and heterogeneity across ethnicities. Most significant associations were outside our candidate linkage regions and were coincident within a gene or intergenic region, with two exceptions in European-American families: (a) within previously identified linkage region on chromosome 2, two significant GLI2-TFCP2L1 associations with weight, and (b) one chromosome 11 variant near CADM1-LINC00900 with pleiotropic blood pressure effects. Conclusions This multiethnic family study found genetic heterogeneity and coincident associations (with one case of pleiotropy), highlighting the importance of including diverse populations in genetic research and illustrating the complex genetic architecture underlying MetS.


2019 ◽  
Vol 15 ◽  
pp. P919-P920
Author(s):  
James Jaworski ◽  
Brian W. Kunkle ◽  
Farid Rajabli ◽  
Larry D. Adams ◽  
Takiyah D. Starks ◽  
...  

2005 ◽  
Vol 181 (2) ◽  
pp. 389-397 ◽  
Author(s):  
Adebowale A. Adeyemo ◽  
Thomas Johnson ◽  
Joseph Acheampong ◽  
Johnnie Oli ◽  
Godfrey Okafor ◽  
...  

2009 ◽  
Vol 24 (8) ◽  
pp. 2414-2420 ◽  
Author(s):  
A. D. Rule ◽  
B. L. Fridley ◽  
S. C. Hunt ◽  
Y. Asmann ◽  
E. Boerwinkle ◽  
...  

Diabetes ◽  
2001 ◽  
Vol 50 (12) ◽  
pp. 2850-2857 ◽  
Author(s):  
R. S. Lindsay ◽  
S. Kobes ◽  
W. C. Knowler ◽  
P. H. Bennett ◽  
R. L. Hanson

Sign in / Sign up

Export Citation Format

Share Document