Description and results of birth defects surveillance and follow‐up programs in Bogotá and Cali, Colombia , 2002–2019

Abstract Study question Are the neonatal outcomes normal of babies derived from the transfer of blastocysts derived from mono-pronuclear(1PN) zygotes? Summary answer There was no effect on growth or increase in congenital anomalies up to 18-months in babies of 1PN-derived births. What is known already 1PN zygotes are observed in ART, albeit at a low rate. We have previously reported that 80.7% of 1PN zygotes derived from IVF or ICSI had a biparental chromosome using Live Cell imaging techniques, and some of these developed to the blastocyst stage (Tokoro et al. ASRM 2013). Furthermore, we have reported that these blastocysts can result in a viable pregnancy and healthy live birth (Tsuji et al. ASRM2020). However, there is some uncertainty about the developmental mechanism of 1PN zygotes, and there is no clear consensus on their clinical utility. Study design, size, duration This was a retrospective study which included 55 cases where there was a live birth after single embryo transfer of a blastocyst derived from 1PN zygote. The incidence of birth defects, birth weight was recorded as well as a physical development survey of 25 children who responded to the 18-months follow-up survey. The time period was 72 months (January 2013 to December 2018). Participants/materials, setting, methods Patients seeking fertility treatment at an established private IVF clinic. We compared the birth weight, birth after18-months height and weight of children born to 1PN zygotes with data from a control, 2PN group. Statistical significance was determined using the t-test (level of P < 0.05). Main results and the role of chance The incidence of birth defects in 1PN embryo-derived infants was 1.8% (1/55). The average birth weight of boys in the 1PN group was 3105.6+/–360.3g, which was not significantly different from 3041.0+/–443.3 g in the 2PN group. In girls, the average birth weight was 3085.7+/–454.9 g in the 1PN group, which was not significantly different from the 2PN group (2938.9+/–311.5 g). The average height at 18-months, was 81.6+/–2.5 cm vs 80.5+/–3.4 cm for boys; 79.0+/–1.8 cm vs 79.0+/–3.4 cm for girls in the 1PN and 2PN groups, respectively. The average body weights of the 1PN and 2PN groups were 11.1+/–1.1 kg vs 10.7+/–1.1 kg for boys; 9.7+/–0.9 kg vs 10.1+/–1.0 kg for girls, respectively. There was no significant difference in average height and weight up-to the 18-months follow-up survey. Limitations, reasons for caution The incidence of 1PN derived births is low and the study was limited to cases of single blastocyst embryo transfer. Wider implications of the findings: The incidence of congenital anomalies in Japan was around 1.7 to 2%, and the incidence was similar in the 1PN. There was no difference in the birth weight and 18-months follow-up survey of the 1PN compared with the 2PN. We have demonstrated that there is clinical utility of 1PN embryo. Trial registration number Not applicable

Download Full-text

Follow-up studies of children with birth defects in the Medical Birth Registry of Norway: A review

Norsk Epidemiologi ◽

10.5324/nje.v15i1.222 ◽

2009 ◽

Vol 15 (1) ◽

Author(s):

Rolv T. Lie ◽

Rolv Skjærven

Keyword(s):

Birth Defects ◽

Birth Defect ◽

Similar Type ◽

Next Generation ◽

Font Size ◽

Birth Registry ◽

Current Review ◽

Medical Birth Registry ◽

Follow Up Studies

In two studies published from data in the Medical Birth Registry of Norway we described the survival, tendency to reproduce and subsequent recurrence of birth defects in offspring for children with a range of categories of birth defects. The studies were done separately for girls and boys. The current review summarizes data from these reports and makes some comparisons between boys and girls. More boys than girls are born with birth defects. The survival and tendency to reproduce showed great variation from milder to more serious types of defects, and this pattern was relatively consistent for boys and girls. The recurrence of birth defects in the offspring was almost entirely for a similar type of birth defect. For boys with birth defects, however, there was also a tendency to have offspring with other types of birth defects. A total of 0.5% of birth defects in the next generation was attributable to mothers who themselves had birth defects. For fathers with birth defects this number was higher (1.6%) both because more boys were born with birth defects in the previous generation, but also because fathers pass on more birth defects to the next generation

Download Full-text

THE COMBINATION OF LADD’S SYNDROME WITH CONGENITAL HYPERTROPHIC PYLORIC STENOSIS

Hepatology and Gastroenterology ◽

10.25298/2616-5546-2020-4-2-212-216 ◽

2020 ◽

Vol 4 (2) ◽

pp. 212-216

Author(s):

V. V. Navasad ◽

◽

V. I. Kavalchuk ◽

E. A. Navasad ◽

◽

...

Keyword(s):

Gastrointestinal Tract ◽

Birth Defects ◽

Pyloric Stenosis ◽

Hypertrophic Pyloric Stenosis ◽

Circular Muscle ◽

Muscle Layer ◽

Interstitial Tissue ◽

Pathological Conditions ◽

Congenital Hypertrophic Pyloric Stenosis

Background. The combination of the two congenital pathological conditions – compression of the duodenum by embryonic cords of the peritoneum and congenital inversion of the small intestine and right half of the colon due to incomplete bowel rotation – was described in detail by W. E. Ladd in 1932, thus the pathology is known as “Ladd’s syndrome” (LS). Congenital pyloric stenosis belongs to a group of severe birth defects. The disease is based on a congenital violation of the morphological structures of the pyloric sphincter of the stomach due to hypertrophy of the circular muscle layer and interstitial tissue leading to pyloric stenosis and impaired patency in this part of the gastrointestinal tract. Objective. Demonstration of diagnostics and treatment peculiarities of a rare case of a combined pathology of the gastrointestinal tract in a newborn. Material and methods. The data from clinical observation of the patient M., 3 days old, who was treated in the neonatal Department of the Grodno regional children’s clinical hospital (GODKB) since December 2018 till March 2019. Results. The child was found to have a combination of Ladd’s syndrome with congenital hypertrophic pyloric stenosis. Successful correction of the birth defects was performed. Conclusion. We have presented a case report that hasn’t been yet described in literature. Despite the diffculties in diagnostics, the patient was discharged with recovery. The follow-up examination in 2020 revealed no abnormalities in the child’s development.

Download Full-text

Identifying possible inaccuracy in reported birth head circumference measurements among infants in the US Zika Pregnancy and Infant Registry

10.21203/rs.3.rs-1189991/v1 ◽

2021 ◽

Author(s):

Nicole M. Roth ◽

Kate Russell Woodworth ◽

Shana Godfred-Cato ◽

Augustina M. Delaney ◽

Samantha M. Olson ◽

...

Keyword(s):

Literature Review ◽

Expert Opinion ◽

Birth Defects ◽

Growth Velocity ◽

Head Circumference ◽

Zika Virus ◽

Case Definition ◽

Zikv Infection ◽

The Us

Abstract The US Zika Pregnancy and Infant Registry (USZPIR) monitors infants born to mothers with confirmed or possible Zika virus (ZIKV) infection during pregnancy. The surveillance case definition for Zika-associated birth defects includes microcephaly based on head circumference (HC). We assessed birth and follow-up data from infants with birth HC measurements <3rd percentile and birthweight ≥10th percentile to determine possible misclassification of microcephaly.We developed a schema informed by literature review and expert opinion to identify possible HC measurement inaccuracy using HC growth velocity and neuroimaging results. Two or more HC measurements between 2-12 months of age were required for assessment. Inaccuracy in birth HC measurement was suspected if growth velocity was >3 centimeters/month in the first three months or HC was consistently >25th percentile during follow-up. Normal neuroimaging was considered supportive of HC measurement inaccuracy. Of 6,799 infants, 351 (5.2%) had Zika-associated birth defects, of which 111 had birth HC measurements <3rd percentile and birthweight ≥10th percentile. Of 84/111 infants with sufficient follow-up, 38/84 (45%) were classified as having possible inaccuracy of birth HC measurement, 19/84 (23%) had HC ≥3rd percentile on follow-up without meeting criteria for possible inaccuracy, and 27/84 (32%) had continued HC <3rd percentile. After excluding possible inaccuracies, the proportion of infants with Zika-associated birth defects including microcephaly decreased from 5.2% to 4.6%.About one-third of infants with Zika-associated birth defects had only microcephaly, but indications of possible measurement inaccuracy were common. Implementation of this schema in ZIKV infection during pregnancy studies can reduce misclassification of microcephaly.

Download Full-text