HLA antigen frequency in the Koya tribe of Andhra Pradesh, India

1983 ◽  
Vol 62 (2) ◽  
pp. 147-150 ◽  
Author(s):  
S. S. Papiha ◽  
J. Wentzel ◽  
D. F. Roberts ◽  
Y. Subba Rao ◽  
C. M. Habibullah
Keyword(s):  
Andhra Pradesh ◽  
Hla Antigen ◽  
Antigen Frequency

Racial Differences in HLA Antigen Frequency and Hypertensive Renal Failure

1991 ◽  
Vol 4 (5 Pt 1) ◽  
pp. 393-398 ◽  
Author(s):  
B. I. Freedman ◽  
M. A. Espeland ◽  
E. R. Heise ◽  
P. L. Adams ◽  
V. M. Buckalew ◽  
...  
Keyword(s):  
Renal Failure ◽  
Racial Differences ◽  
Hla Antigen ◽  
Antigen Frequency

HLA-Antigen Frequency in an Iraqi Population

2008 ◽  
Vol 10 (4) ◽  
pp. 303-305 ◽  
Author(s):  
Ammar A. R. Jabbar ◽  
Heather M. Dick
Keyword(s):  
Hla Antigen ◽  
Antigen Frequency

scholarly journals Human Leukocyte Antigen: Class I Allele Frequencies and Haplotype Distributionin a Tertiary Care Hospital in Bangladesh

2018 ◽  
Vol 44 (1) ◽  
pp. 1-8
Author(s):  
Sharmin Sultana ◽  
Shahina Tabassum ◽  
Afzalun Nessa
Keyword(s):  
Human Leukocyte Antigen ◽  
Genetic Relationships ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Class I ◽  
Care Hospital ◽  
Hla Antigen ◽  
Leukocyte Antigen ◽  
Haplotype Distribution ◽  
Antigen Frequency

Human leukocyte antigen (HLA) are cell surface glycoproteins encoded by Major Histocompatibility Complex (MHC) geneof human genome. HLA antigen frequency and haplotype distribution are useful for determining disease associations, origin, migration and genetic relationships between populations and predicting the outcome of transplantation. Thus, the present study was carried outto identify HLA class I (HLA-A and HLA-B) antigen and haplotype distribution among a selected Bangladeshi population. This retrospective study was conducted among 1070 individuals who were referred by cliniciansfor HLA typing at the Tissue Typing Laboratory of the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU) during the period 2009 to 2011. For HLA typing, Blood was collected in heparin containing tube and the laboratory tests were performed by the microlymphocytotoxicity technique according to manufacturer’s instructions.Out of 19 HLA-A and 37HLA-B antigens tested, a total of 19/19 and 36/37 antigens were detectedrespectively in this study. The most frequent antigens of HLA-A and HLA-B detected were A11 (25.4%), A24 (16.6%), B75 (18.1%) and B35 (11.3%). The least antigen frequency detected for HLA-A locus were A69 (0.09%), A26 (0.28%), A34 (0.28%), while for HLA-B locus were B81 (0.09%) and B56 (0.09%). Among the HLA-A and HLA-B antigens, some alleles were found to be homozygote such as A11 (4.0%), A2 (2.7%), A24 (2.1%) andB75 (2.4%), B35 (1.8%), and B44 (1.4%) respectively. The most frequent haplotype in the study populationwereA11: B75 (4.9%). The most frequent antigens of HLA-A and HLA-B detected were A11 (25.4%), B75 (18.1%) respectively. The distribution of HLA haplotypes among the study population indicates that it has the influence of Oriental and Asian populations. Thus, this study will be helpful to provide valuable information for population genetics and HLA disease association analysis.Bangladesh Med Res Counc Bull 2018; 44(1):01-08

HLA antigen frequency in granuloma annulare

1984 ◽  
Vol 110 (1) ◽  
pp. 57-59 ◽  
Author(s):  
D. MIDDLETON ◽  
G.E. ALLEN
Keyword(s):  
Granuloma Annulare ◽  
Hla Antigen ◽  
Antigen Frequency

HLA Antigen Frequencies in Malignant Melanoma Patients. A Second Study

1984 ◽  
Vol 70 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Dario Rovini ◽  
Virgilio Sacchini ◽  
Virginia Codazzi ◽  
Maurizio Vaglini ◽  
Maria Teresa Illeni
Keyword(s):  
Malignant Melanoma ◽  
Blood Donors ◽  
Resistance Factor ◽  
Control Group ◽  
Healthy Controls ◽  
Hla Antigen ◽  
The Future ◽  
Melanoma Patients ◽  
Antigen Frequency

Two groups of malignant melanoma (MM) patients were considered: the group of 140 patients previously published and a new one of 58, both typed for HLA-A, -B and -C antigens at the Istituto Nazionale Tumori of Milan. The control group consisted of healthy blood donors not related to the patients. Only the HLA-Bw35 antigen frequency was significantly decreased in both groups of patients. To investigate the HLA-A and -B blanks, 62 MM patients and 90 healthy controls, who showed non-homozygotic blanks when they were firstly HLA typed, volunteered to repeat the HLA typging three or more times in a 2-year period. A significant increase in both HLA-A and -B blanks in the patients as compared to controls was noticed (p = 3 × 10−4 and 3 × 10−5, respectively). In the future, attempts should be made to correlate the HLA antigen and blank frequencies with the evolution of the disease and, also, to verify the hypothesis that the HLA-Bw35 antigen may be an associated resistance factor against the tumor.

HLA antigen frequency in erythema multiforme and in recurrent herpes simplex

2008 ◽  
Vol 21 (3) ◽  
pp. 264-267 ◽  
Author(s):  
D. Middleton ◽  
T. H. Hutchison ◽  
J. Lynd
Keyword(s):  
Herpes Simplex ◽  
Erythema Multiforme ◽  
Hla Antigen ◽  
Recurrent Herpes ◽  
Antigen Frequency

The Mechanism of Platelet Aggregation Induced by HLA-Related Antibodies

1996 ◽  
Vol 76 (05) ◽  
pp. 774-779 ◽  
Author(s):  
John T Brandt ◽  
Carmen J Julius ◽  
Jeanne M Osborne ◽  
Clark L Anderson
Keyword(s):  
Platelet Aggregation ◽  
Platelet Activation ◽  
Complement Activation ◽  
Thromboembolic Disease ◽  
Clinical Samples ◽  
Hla Antigen ◽  
Aggregation Response ◽  
Immune Mediated ◽  
Dependent Pathway

SummaryImmune-mediated platelet activation is emerging as an important pathogenic mechanism of thrombosis. In vitro studies have suggested two distinct pathways for immune-mediated platelet activation; one involving clustering of platelet FcyRIIa, the other involving platelet-associated complement activation. HLA-related antibodies have been shown to cause platelet aggregation, but the mechanism has not been clarified. We evaluated the mechanism of platelet aggregation induced by HLA-related antibodies from nine patients. Antibody to platelet FcyRIIa failed to block platelet aggregation with 8/9 samples, indicating that engagement of platelet FcyRIIa is not necessary for the platelet aggregation induced by HLA-related antibodies. In contrast, platelet aggregation was blocked by antibodies to human C8 (5/7) or C9 (7/7). F(ab’)2 fragments of patient IgG failed to induce platelet activation although they bound to HLA antigen on platelets. Intact patient IgG failed to aggregate washed platelets unless aged serum was added. The activating IgG could be adsorbed by incubation with lymphocytes and eluted from the lymphocytes. These results indicate that complement activation is involved in the aggregation response to HLA-related antibodies. This is the first demonstration of complement-mediated platelet aggregation by clinical samples. Five of the patients developed thrombocytopenia in relationship to blood transfusion and two patients developed acute thromboembolic disease, suggesting that these antibodies and the complement-dependent pathway of platelet aggregation may be of clinical significance.

Existance of Soil Flora in the Soils of Oil Palm Growing Areas of Andhra Pradesh

2011 ◽  
Vol 3 (8) ◽  
pp. 23-27
Author(s):  
G. Swarna latha G. Swarna latha ◽  
◽  
Dr. Amara Srinivasulu ◽  
G. Suneetha G. Suneetha
Keyword(s):  
Oil Palm ◽  
Andhra Pradesh
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