Racial Differences in HLA Antigen Frequency and Hypertensive Renal Failure

Human leukocyte antigen (HLA) are cell surface glycoproteins encoded by Major Histocompatibility Complex (MHC) geneof human genome. HLA antigen frequency and haplotype distribution are useful for determining disease associations, origin, migration and genetic relationships between populations and predicting the outcome of transplantation. Thus, the present study was carried outto identify HLA class I (HLA-A and HLA-B) antigen and haplotype distribution among a selected Bangladeshi population. This retrospective study was conducted among 1070 individuals who were referred by cliniciansfor HLA typing at the Tissue Typing Laboratory of the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU) during the period 2009 to 2011. For HLA typing, Blood was collected in heparin containing tube and the laboratory tests were performed by the microlymphocytotoxicity technique according to manufacturer’s instructions.Out of 19 HLA-A and 37HLA-B antigens tested, a total of 19/19 and 36/37 antigens were detectedrespectively in this study. The most frequent antigens of HLA-A and HLA-B detected were A11 (25.4%), A24 (16.6%), B75 (18.1%) and B35 (11.3%). The least antigen frequency detected for HLA-A locus were A69 (0.09%), A26 (0.28%), A34 (0.28%), while for HLA-B locus were B81 (0.09%) and B56 (0.09%). Among the HLA-A and HLA-B antigens, some alleles were found to be homozygote such as A11 (4.0%), A2 (2.7%), A24 (2.1%) andB75 (2.4%), B35 (1.8%), and B44 (1.4%) respectively. The most frequent haplotype in the study populationwereA11: B75 (4.9%). The most frequent antigens of HLA-A and HLA-B detected were A11 (25.4%), B75 (18.1%) respectively. The distribution of HLA haplotypes among the study population indicates that it has the influence of Oriental and Asian populations. Thus, this study will be helpful to provide valuable information for population genetics and HLA disease association analysis.Bangladesh Med Res Counc Bull 2018; 44(1):01-08

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HLA antigen frequency in granuloma annulare

British Journal of Dermatology ◽

10.1111/j.1365-2133.1984.tb07312.x ◽

1984 ◽

Vol 110 (1) ◽

pp. 57-59 ◽

Cited By ~ 13

Author(s):

D. MIDDLETON ◽

G.E. ALLEN

Keyword(s):

Granuloma Annulare ◽

Hla Antigen ◽

Antigen Frequency

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Age at Onset, Sex Distribution and HLA Antigen Frequency in Patients with Primary Glomerulonephritis Progressing to Terminal Uraemia

Scandinavian Journal of Urology and Nephrology ◽

10.3109/00365598709180787 ◽

1987 ◽

Vol 21 (4) ◽

pp. 301-306 ◽

Cited By ~ 4

Author(s):

Björn Forsberg ◽

Ulf Johnson

Keyword(s):

Age At Onset ◽

Sex Distribution ◽

Hla Antigen ◽

Primary Glomerulonephritis ◽

Antigen Frequency

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HLA Antigen Frequencies in Malignant Melanoma Patients. A Second Study

Tumori Journal ◽

10.1177/030089168407000105 ◽

1984 ◽

Vol 70 (1) ◽

pp. 29-33 ◽

Cited By ~ 7

Author(s):

Dario Rovini ◽

Virgilio Sacchini ◽

Virginia Codazzi ◽

Maurizio Vaglini ◽

Maria Teresa Illeni

Keyword(s):

Malignant Melanoma ◽

Blood Donors ◽

Resistance Factor ◽

Control Group ◽

Healthy Controls ◽

Hla Antigen ◽

The Future ◽

Melanoma Patients ◽

Antigen Frequency

Two groups of malignant melanoma (MM) patients were considered: the group of 140 patients previously published and a new one of 58, both typed for HLA-A, -B and -C antigens at the Istituto Nazionale Tumori of Milan. The control group consisted of healthy blood donors not related to the patients. Only the HLA-Bw35 antigen frequency was significantly decreased in both groups of patients. To investigate the HLA-A and -B blanks, 62 MM patients and 90 healthy controls, who showed non-homozygotic blanks when they were firstly HLA typed, volunteered to repeat the HLA typging three or more times in a 2-year period. A significant increase in both HLA-A and -B blanks in the patients as compared to controls was noticed (p = 3 × 10−4 and 3 × 10−5, respectively). In the future, attempts should be made to correlate the HLA antigen and blank frequencies with the evolution of the disease and, also, to verify the hypothesis that the HLA-Bw35 antigen may be an associated resistance factor against the tumor.

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Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population

Advances in Hematology ◽

10.1155/2013/215454 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 12

Author(s):

Divjot Singh Lamba ◽

Ravneet Kaur ◽

Sabita Basu

Keyword(s):

Racial Differences ◽

Blood Group ◽

Blood Donors ◽

Blood Group Antigen ◽

Blood Group System ◽

Blood Group Antigens ◽

Young Females ◽

Group System ◽

Clinically Significant ◽

Antigen Frequency

Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine.Study Design and Methods. This is a prospective study, involving 1000 healthy regular repeat voluntary blood donors associated with the department. The clinically significant minor blood group antigens of these donors were studied.Results. Out of 1000 healthy regular repeat voluntary blood donors, 93% were D positive and 2.8% were K positive. Amongst the Rh antigens, e was the most common (99%), followed by D (93%), C (85.1%), c (62.3%), and E (21.5%). Within the MNS blood group system, antigen frequency was M (88%), N (57.5%), S (57.8%), and s (87.5%). Within the Duffy blood group system, antigen frequency wasFya(87.3%) andFyb(58.3%).Conclusions. This data base will help us to prevent alloimmunisation in young females, pregnant women, and patients who are expected to require repeated transfusions in life by providing them with antigen matched blood. Antigen negative blood can also be made available without delay to already alloimmunized multitransfused patients.

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