A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells

2012 ◽  
Vol 124 (50) ◽  
pp. 12677-12681 ◽  
Author(s):  
Jungwoon Lee ◽  
Yan Xia ◽  
Mi-Young Son ◽  
Guanghai Jin ◽  
Binna Seol ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Somatic Cells ◽  
Human Pluripotent Stem Cells ◽  
Pluripotent State ◽  
Undifferentiated State

scholarly journals Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

2015 ◽  
Vol 4 (5) ◽  
pp. 939-952 ◽  
Author(s):  
Richard Siller ◽  
Sebastian Greenhough ◽  
Elena Naumovska ◽  
Gareth J. Sullivan
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Hepatocyte Differentiation

scholarly journals Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells

2017 ◽  
Vol 24 ◽  
pp. 61-68 ◽  
Author(s):  
Azuma Kimura ◽  
Taro Toyoda ◽  
Yohei Nishi ◽  
Makoto Nasu ◽  
Akira Ohta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Progenitor Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

Science ◽  
2013 ◽  
Vol 341 (6146) ◽  
pp. 651-654 ◽  
Author(s):  
Pingping Hou ◽  
Yanqin Li ◽  
Xu Zhang ◽  
Chun Liu ◽  
Jingyang Guan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Fate ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Genetic Manipulation ◽  
Expression Profiles ◽  
Somatic Cells ◽  
Embryonic Stem ◽  
Gene Expression Profiles ◽  
Clinical Applications

Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource, with potential for studying disease and use in regenerative medicine. However, genetic manipulation and technically challenging strategies such as nuclear transfer used in reprogramming limit their clinical applications. Here, we show that pluripotent stem cells can be generated from mouse somatic cells at a frequency up to 0.2% using a combination of seven small-molecule compounds. The chemically induced pluripotent stem cells resemble embryonic stem cells in terms of their gene expression profiles, epigenetic status, and potential for differentiation and germline transmission. By using small molecules, exogenous “master genes” are dispensable for cell fate reprogramming. This chemical reprogramming strategy has potential use in generating functional desirable cell types for clinical applications.

scholarly journals Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

2012 ◽  
Vol 30 (7) ◽  
pp. 715-720 ◽  
Author(s):  
Stuart M Chambers ◽  
Yuchen Qi ◽  
Yvonne Mica ◽  
Gabsang Lee ◽  
Xin-Jun Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Developmental Timing ◽  
Small Molecule Inhibition
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