Micro‐Lensed Fiber Laser Desorption Mass Spectrometry Imaging Reveals Subcellular Distribution of Drugs within Single Cells

2020 ◽  
Vol 132 (41) ◽  
pp. 18020-18027
Author(s):  
Yifan Meng ◽  
Xiaoling Cheng ◽  
Tongtong Wang ◽  
Wei Hang ◽  
Xiaoping Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fiber Laser ◽  
Subcellular Distribution ◽  
Mass Spectrometry Imaging ◽  
Single Cells ◽  
Laser Desorption ◽  
Laser Desorption Mass Spectrometry ◽  
Desorption Mass Spectrometry

Analysis of artificial proteins by matrix-assisted laser desorption mass spectrometry

1992 ◽  
Vol 114 (19) ◽  
pp. 7584-7585 ◽  
Author(s):  
Ronald C. Beavis ◽  
Brian T. Chait ◽  
Howard S. Creel ◽  
Maurille J. Fournier ◽  
Thomas L. Mason ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Laser Desorption Mass Spectrometry ◽  
Desorption Mass Spectrometry ◽  
Artificial Proteins ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

Laser desorption mass spectrometry of photopolymerized fullerene (C60) films

1993 ◽  
Vol 97 (19) ◽  
pp. 5036-5039 ◽  
Author(s):  
D. S. Cornett ◽  
I. J. Amster ◽  
M. A. Duncan ◽  
A. M. Rao ◽  
P. C. Eklund
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Fullerene C60 ◽  
Laser Desorption Mass Spectrometry ◽  
Desorption Mass Spectrometry ◽  
C60 Films

Laser Desorption Mass Spectrometry of Synthetic Multiporphyrin Arrays

1997 ◽  
Vol 01 (01) ◽  
pp. 93-99 ◽  
Author(s):  
DAVID FENYO ◽  
BRIAN T. CHAIT ◽  
THOMAS E. JOHNSON ◽  
JONATHAN S. LINDSEY
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Maldi Ms ◽  
Active Materials ◽  
Laser Desorption Mass Spectrometry ◽  
Desorption Mass Spectrometry ◽  
Laser Illumination ◽  
Powerful Analytical Tool ◽  
Maldi Process ◽  
Insight Into

Laser desorption mass spectrometry and matrix-assisted laser desorption mass spectrometry (MALDI-MS) have been investigated for the analysis of a set of synthetic compounds containing one, two, five, eight or nine porphyrins. Intact singly ionized molecule ions were observed for each compound and the spectra were readily interpretable. The use of a matrix of 4-hydroxy-α-cyano-cinnamic acid greatly diminished the extent of fragmentation. Examination of the resulting mass spectra provides insight into aspects of the MALDI process. The present results show that high molecular weight photochemically active materials that absorb strongly at the wavelength of laser illumination can be analysed effectively and that MALDI-MS is a powerful analytical tool for synthetic chemistry of porphyrin-based molecules with dimensions ranging to 10 nm. The strong molecule ions observed for the largest compounds investigated ( Zn 8-octamer, Zn 9-nonamer) indicates that this method should be applicable to even larger porphyrin arrays.

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