Stereochemistry at Bürgenstock: Chemical Biology and Organic Synthesis in Focus

2008 ◽  
Vol 47 (30) ◽  
pp. 5496-5499
Author(s):  
Christian P. R. Hackenberger ◽  
Hermann A. Wegner ◽  
Andreas Zumbuehl
Keyword(s):  
Organic Synthesis ◽  
Chemical Biology

scholarly journals 1,2,3-Triazoles: Synthesis and Biological Application

2020 ◽  
Author(s):  
Abdul Aziz Ali
Keyword(s):  
Drug Discovery ◽  
Supramolecular Chemistry ◽  
Organic Synthesis ◽  
Chemical Biology ◽  
Materials Science ◽  
Biological Activities ◽  
Fluorescent Imaging ◽  
Polymer Chemistry ◽  
Privileged Structure ◽  
Synthetic Approaches

Among nitrogen-containing heterocyclic compounds, 1,2,3-triazoles are privileged structure motif and received a great deal of attention in academics and industry. Even though absent in nature, 1,2,3-triazoles have found broad applications in drug discovery, organic synthesis, polymer chemistry, supramolecular chemistry, bioconjugation, chemical biology, fluorescent imaging, and materials science. Therefore, the development of facile and straightforward methodology for the synthesis of 1,2,3-triazoles is of noteworthy interest. In this study, emphasis will be given to numerous synthetic approaches for the synthesis of 1,2,3-triazoles, especially the popular click chemistry approach. Furthermore, several biological activities of this promising heterocycle will also be discussed.

ChemInform Abstract: The Use of 3,6-Pyridazinediones in Organic Synthesis and Chemical Biology

ChemInform ◽  
2016 ◽  
Vol 47 (9) ◽  
pp. no-no
Author(s):  
Maximillian T. W. Lee ◽  
Antoine Maruani ◽  
Vijay Chudasama
Keyword(s):  
Organic Synthesis ◽  
Chemical Biology

scholarly journals The allylic chalcogen effect in olefin metathesis

2010 ◽  
Vol 6 ◽  
pp. 1219-1228 ◽  
Author(s):  
Yuya A Lin ◽  
Benjamin G Davis
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Olefin Metathesis ◽  
Chemical Biology ◽  
Positive Influence ◽  
Efficient Synthesis ◽  
Cross Metathesis ◽  
Allyl Sulfide ◽  
Hydroxy Groups ◽  
Allyl Sulfides

Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an allylic hydroxy group in metathesis has been known for more than 10 years, and many organic chemists have taken advantage of this positive influence for efficient synthesis of natural products. Recently, the discovery of the rate enhancement by allyl sulfides in aqueous cross-metathesis has allowed the first examples of such a reaction on proteins. This led to a new benchmark in substrate complexity for cross-metathesis and expanded the potential of olefin metathesis for other applications in chemical biology. The enhanced reactivity of allyl sulfide, along with earlier reports of a similar effect by allylic hydroxy groups, suggests that allyl chalcogens generally play an important role in modulating the rate of olefin metathesis. In this review, we discuss the effect of allylic chalcogens in olefin metathesis and highlight its most recent applications in synthetic chemistry and protein modifications.

scholarly journals Aqueous olefin metathesis: recent developments and applications

2019 ◽  
Vol 15 ◽  
pp. 445-468 ◽  
Author(s):  
Valerio Sabatino ◽  
Thomas R Ward
Keyword(s):  
Double Bond ◽  
Organic Synthesis ◽  
Olefin Metathesis ◽  
Chemical Biology ◽  
Polymer Chemistry ◽  
Attractive Alternative ◽  
Bond Forming ◽  
Recent Developments ◽  
Tremendous Impact ◽  
Made In

Olefin metathesis is one of the most powerful C–C double-bond-forming reactions. Metathesis reactions have had a tremendous impact in organic synthesis, enabling a variety of applications in polymer chemistry, drug discovery and chemical biology. Although challenging, the possibility to perform aqueous metatheses has become an attractive alternative, not only because water is a more sustainable medium, but also to exploit biocompatible conditions. This review focuses on the progress made in aqueous olefin metatheses and their applications in chemical biology.

scholarly journals Asymmetric Synthesis of Stereogenic Phosphorus P(V) Centers Using Chiral Nucleophilic Catalysis

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3661
Author(s):  
Ahmed Numan ◽  
Matthew Brichacek
Keyword(s):  
Transition Metal ◽  
Asymmetric Synthesis ◽  
Organic Synthesis ◽  
Chemical Biology ◽  
Transition Metal Catalysis ◽  
Nucleophilic Catalysis ◽  
Metal Catalysis ◽  
Chiral Catalyst ◽  
Stereocontrolled Synthesis ◽  
Stereogenic Centers

Organophosphates have been widely used in agrochemistry, as reagents for organic synthesis, and in biochemistry. Phosphate mimics possessing four unique substituents, and thereby a chirality center, are useful in transition metal catalysis and as nucleotide therapeutics. The catalytic, stereocontrolled synthesis of phosphorus-stereogenic centers is challenging and traditionally depends on a resolution or use of stochiometric auxiliaries. Herein, enantioenriched phosphorus centers have been synthesized using chiral nucleophilic catalysis. Racemic H-phosphinate species were coupled with nucleophilic alcohols under halogenating conditions. Chiral phosphonate products were synthesized in acceptable yields (33–95%) and modest enantioselectivity (up to 62% ee) was observed after identification of an appropriate chiral catalyst and optimization of the solvent, base, and temperature. Nucleophilic catalysis has a tremendous potential to produce enantioenriched phosphate mimics that could be used as prodrugs or chemical biology probes.

Preface

2009 ◽  
Vol 81 (2) ◽  
pp. iv
Author(s):  
Sang-gi Lee
Keyword(s):  
Natural Products ◽  
Bioorganic Chemistry ◽  
Organic Synthesis ◽  
Chemical Biology ◽  
Organic Materials ◽  
Process Development ◽  
Science And Technology ◽  
Chemical Society ◽  
Scientific Program ◽  
Natural Products Synthesis

The 17th International Conference on Organic Synthesis (ICOS 17) was held in Daejeon, Korea during 22-27 June 2008 under the joint chairmanship of Prof. Eun Lee (Seoul National University) and Prof. Sunggak Kim (Korean Advanced Institute of Science and Technology). Professor Sung Ho Kang (Korean Advanced Institute of Science and Technology) acted as Chair of the Organizing Committee for the event, which is the latest in a regular biennial series that was initiated in 1974 under the auspices of IUPAC. On this occasion, the Korean Chemical Society acted as cosponsors, and the Conference enjoyed generous financial support from the Korean Research Foundation, the Korean Federation of Science and Technology Societies, and a sponsorship club representing Korean industries.Almost 1000 participants, including 412 foreign scientists, attended from 32 countries, once again demonstrating the ongoing international appeal and topicality of organic synthesis. The scientific program of ICOS 17 was characterized by in-depth coverage of many familiar aspects of the topic, such as synthetic methodology, natural products synthesis, bioorganic chemistry, chemical biology, organic materials, and medicinal chemistry. The program was delineated in five broad themes entitled:- Discovery of new reagents and reactions- Challenges and new trends in natural products synthesis- Prospects in bioorganic chemistry and chemical biology- Visions in organic materials researches- Events in drug discovery and process developmentA total of 51 invited lectures were delivered; in addition to 36 from academia, 13 emanated from industry and 2 from research institutes. A highlight of the lecture program was the Thieme-IUPAC prize lecture presented by Prof. Dean Toste (University of California, Berkeley, USA). The poster program was particularly well supported, and no less than 533 posters were presented during two sessions.This issue of Pure and Applied Chemistry comprises a collection of 12 papers based on lectures delivered at ICOS 17. The organizers are particularly grateful to all who contributed to this issue for their timely efforts. The topics of these papers feature some of the major themes of the conference and thus furnish a representative insight into the scientific program and capture exciting new developments and trends. This series will continue in Bergen, Norway on 2-5 August 2010, and it is confidently expected that it will continue to fulfill an important scientific role in highlighting ongoing advances in modern organic synthesis.Sang-gi LeeConference Editor

The Use of 3,6-Pyridazinediones in Organic Synthesis and Chemical Biology

2016 ◽  
Vol 40 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Maximillian T. W. Lee ◽  
Antoine Maruani ◽  
Vijay Chudasama
Keyword(s):  
Organic Synthesis ◽  
Chemical Biology
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