The effect of pH on the hydrolytic degradation of poly(ε-caprolactone)-block-poly(ethylene glycol) copolymers

2012 ◽  
Vol 127 (3) ◽  
pp. 2046-2056 ◽  
Author(s):  
Xian Jun Loh
Keyword(s):  
Ethylene Glycol ◽  
Hydrolytic Degradation ◽  
Poly Ethylene Glycol ◽  
Effect Of Ph ◽  
Poly Ethylene

Mechanical properties and hydrolytic degradation of methoxy poly(ethylene glycol)-b-poly(DL-lactide-coglycolide- co-ε-caprolactone) diblock copolymer films

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Nongnit Morakot ◽  
Jirasak Threeprom ◽  
Yodthong Baimark
Keyword(s):  
Mechanical Properties ◽  
Weight Loss ◽  
Ethylene Glycol ◽  
Diblock Copolymers ◽  
Hydrolytic Degradation ◽  
Size Exclusion ◽  
Block Length ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
Poly Ethylene

AbstractBiodegradable films of methoxy poly(ethylene glycol)-b-poly(DL-lactideco- glycolide-co-ε-caprolactone) diblock copolymers (MPEG-b-PDLLGCL) were prepared by solution casting method. Effects of MPEG block length and DLL:G:CL ratio of the MPEG-b-PDLLGCL films on their mechanical properties and hydrolytic degradation were studied and discussed. It was found that the mechanical properties of films were strongly dependent on glass transition temperatures (Tg) of the diblock copolymers. The hydrolytic degradation was investigated in phosphatebuffered solution at 37°C. The degraded films were characterized using gravimetry (%water uptake and %weight loss), 1H-NMR spectroscopy, differential scanning calorimetry and size exclusion chromatography. The %weight loss of the degraded films increased and molecular weight decreased on increasing the MPEG block length and incorporating the G and CL units, according to their %water uptakes. The MPEG content of the degraded film decreased and the Tg increased with hydrolytic degradation time.

scholarly journals Effect of pH on the Rate of Curing and Bioadhesive Properties of Dopamine Functionalized Poly(ethylene glycol) Hydrogels

2014 ◽  
Vol 15 (8) ◽  
pp. 2861-2869 ◽  
Author(s):  
Morgan Cencer ◽  
Yuan Liu ◽  
Audra Winter ◽  
Meridith Murley ◽  
Hao Meng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Effect Of Ph ◽  
Poly Ethylene
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