Design and synthesis of novel chalcone derivatives and evaluation of their inhibitory activities against acetylcholinesterase

2021 ◽  
Author(s):  
İlçim Ceyhun ◽  
Şevval Karaca ◽  
Derya Osmaniye ◽  
Begüm N. Sağlık ◽  
Serkan Levent ◽  
...  
Keyword(s):  
Chalcone Derivatives ◽  
Design And Synthesis ◽  
Inhibitory Activities

scholarly journals Design and Synthesis of Benzimidazole-Iminosugars and Their Inhibitory Activities against Glycosidases

2021 ◽  
Vol 41 (7) ◽  
pp. 2861
Author(s):  
Xu Liu ◽  
Lulu Su ◽  
Zhaoxi Zhou ◽  
Liping Niu ◽  
Ligang Gao ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Inhibitory Activities

Design and Synthesis of 2-Substitutedphenyl Benzo[D]Thiazole Derivatives and Their β-Amyloid Aggregation and Cholinesterase Inhibitory Activities

2019 ◽  
Vol 53 (4) ◽  
pp. 322-328 ◽  
Author(s):  
Merve Zengin ◽  
Oya Unsal-Tan ◽  
Tuba Tüylü Küçükkılınç ◽  
Beyza Ayazgok ◽  
Ayla Balkan
Keyword(s):  
Amyloid Aggregation ◽  
Thiazole Derivatives ◽  
Design And Synthesis ◽  
Β Amyloid ◽  
Inhibitory Activities

Structure-guided design and synthesis of isoflavone analogs of GW4064 with potent lipid accumulation inhibitory activities

2018 ◽  
Vol 28 (23-24) ◽  
pp. 3726-3730 ◽  
Author(s):  
Rongmao Qiu ◽  
Guoshun Luo ◽  
Xuerong Cai ◽  
Linyi Liu ◽  
Mingqi Chen ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Design And Synthesis ◽  
Inhibitory Activities

Structure-based synthesis: From natural products to drug prototypes

2009 ◽  
Vol 81 (6) ◽  
pp. 1085-1091 ◽  
Author(s):  
Stephen Hanessian
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Design Element ◽  
X Ray ◽  
Design And Synthesis ◽  
Highly Active ◽  
In Vitro Inhibition ◽  
Inhibitory Activities ◽  
Active Natural

X-ray crystallographic data available from complexes of natural and synthetic molecules with the enzyme thrombin has led to the design and synthesis of truncated and hydrid molecules exhibiting excellent inhibition in vitro. The design element has also been extended to the synthesis and in vitro inhibition of a series of achiral molecules deploying aromatic and heterocyclic core motifs with appropriately functionalized appendages that provide excellent binding interactions at the S1, S2, and S3 sites of thrombin. Excellent selectivity for thrombin over trypsin has also been observed. Thus, studies in total synthesis of highly active natural aeruginosins have inspired further work toward truncated and hybrid analogs with excellent inhibitory activities. Structure-based organic synthesis has guided our research from natural products toward unnatural drug-like prototypes.

ChemInform Abstract: Design and Synthesis of C35-Fluorinated Solamins and Their Growth Inhibitory Activities Against Human Cancer Cell Lines.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Naoto Kojima ◽  
Yuki Suga ◽  
Hiromi Hayashi ◽  
Takao Yamori ◽  
Takehiko Yoshimitsu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Growth Inhibitory ◽  
Inhibitory Activities

scholarly journals Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

SpringerPlus ◽  
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Trung Huu Bui ◽  
Nhan Trung Nguyen ◽  
Phu Hoang Dang ◽  
Hai Xuan Nguyen ◽  
Mai Thanh Thi Nguyen
Keyword(s):  
Xanthine Oxidase ◽  
Chalcone Derivatives ◽  
Design And Synthesis ◽  
Xanthine Oxidase Inhibitors
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