Background: Rheumatoid arthritis is a systemic multifactor disease that presented with symmetrical polyarthritis more
preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of
this disease in unknown, but past researchesshowed that genetically factor play important role beside environmental factors
in susceptibility to this entity. Method:100 patients with rheumatoid arthritis diagnosed upon ACR 2010 criteria enrolled
study. 92 healthy patents also enrolled DNA studying. of both group was extracted through DNA extraction kits by blood
sampling. HLA-DRB1 typing was done by PCR-SSP method. Results: There were no significant differences in HLADRB1
*04, HLADRB1*08 and HLADRB1*11 alleles presentation between patients and healthy controls. Only there were
statically significant correlation between HLA-DRB1*08 and Rheumatoid factor positive patents. (P = 0.025).
Increased responsiveness of rheumatoid factor–producing B cells in seronegative and seropositive rheumatoid arthritis