Mechanisms responsible for the altered pharmacokinetics of Bosentan: analysis utilizing rats with bile duct ligation-induced liver dysfunction

2009 ◽  
Vol 30 (6) ◽  
pp. 326-333 ◽  
Author(s):  
Isao Horiuchi ◽  
Yun-i Mori ◽  
Masato Taguchi ◽  
Fukiko Ichida ◽  
Toshio Miyawaki ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Dysfunction ◽  
Bile Duct Ligation ◽  
Duct Ligation

scholarly journals Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats

2019 ◽  
Vol 22 ◽  
pp. 301-312 ◽  
Author(s):  
Michael D Hambuchen ◽  
Michael D Berquist ◽  
Christy M Simecka ◽  
Mitchell R McGill ◽  
Melinda G Gunnell ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Bile Duct ◽  
Liver Dysfunction ◽  
Hepatic Dysfunction ◽  
Bile Duct Ligation ◽  
Dependent Manner ◽  
Duct Ligation ◽  
Male Wistar Rats ◽  
Experimental Treatments ◽  
Altered Liver

Purpose: Methamphetamine (METH) abuse is associated with hepatic dysfunction related comorbidities such as HIV, hepatitis C, and polysubstance abuse with acetaminophen-containing opioid formulations. We aimed to develop a bile duct ligation (BDL)-induced hepatic dysfunction model for studying both METH and experimental treatments for METH abuse in this comorbidity. Methods: Sham or BDL surgery was performed in male Wistar rats on day 0. Liver function was measured throughout the study. On days 7 and 19, serum pharmacokinetics studies were performed with 1 mg/kg subcutaneous (sc) METH. On day 21, this dose was repeated to determine 2 h post-METH brain concentrations. METH-induced open field behaviors were measured every other day (days 12 - 16) with ascending sc doses (0.3 – 3 mg/kg). Results: BDL transiently increased alanine aminotransferase levels and altered liver structure, which resulted in significantly greater METH serum and brain exposure. In the BDL compared to sham group, there was a longer duration of METH-induced locomotor activity (after 1 and 3 mg/kg) and stereotypy (after 3 mg/kg). Conclusions: In rats, liver dysfunction reduced METH clearance, increased brain METH concentrations, and enhanced METH effects on locomotor activity in a dose dependent manner. In addition, this model could be further developed to simulate the associated hepatic dysfunction of key METH abuse comorbidities for preclinical testing of novel pharmacotherapies for effectiveness and/or toxicity in vulnerable populations.

Effect of bile duct ligation-induced liver dysfunction on methamphetamine pharmacokinetics in male and female rats

2020 ◽  
Vol 215 ◽  
pp. 108190
Author(s):  
Michael D. Berquist ◽  
Mitchell R. McGill ◽  
Anna Mazur ◽  
David L. Findley ◽  
Greg Gorman ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Dysfunction ◽  
Bile Duct Ligation ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Duct Ligation

scholarly journals Decreased C-reactive protein induces abnormal vascular structure in a rat model of liver dysfunction induced by bile duct ligation

2016 ◽  
Vol 22 (3) ◽  
pp. 372-381 ◽  
Author(s):  
Ji Hye Jun ◽  
Jong Ho Choi ◽  
Si Hyun Bae ◽  
Seh Hoon Oh ◽  
Gi Jin Kim
Keyword(s):  
Bile Duct ◽  
Rat Model ◽  
Liver Dysfunction ◽  
Bile Duct Ligation ◽  
Vascular Structure ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Duct Ligation

Liver dysfunction induced by bile duct ligation and galactosamine injection alters cardiac protein synthesis

Metabolism ◽  
2004 ◽  
Vol 53 (8) ◽  
pp. 964-968 ◽  
Author(s):  
Ross J. Hunter ◽  
Vinood B. Patel ◽  
Alastair J. Baker ◽  
Victor R. Preedy
Keyword(s):  
Protein Synthesis ◽  
Bile Duct ◽  
Liver Dysfunction ◽  
Bile Duct Ligation ◽  
Duct Ligation

scholarly journals The influence of liver dysfunction on cyclosporine pharmacokinetics —A comparison between 70 per cent hepatectomy and complete bile duct ligation in dogs—

1989 ◽  
Vol 19 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Shunichi Takaya ◽  
Shunzaburo Iwatsuki ◽  
Takashi Noguchi ◽  
Hisaaki Koie ◽  
Iman Zaghloul ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Dysfunction ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Cyclosporine Pharmacokinetics ◽  
70 Per Cent Hepatectomy

Bid-mediated apoptosis does not contribute to cholestatic liver injury following bile duct ligation

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
P Nalapareddy ◽  
S Schüngel ◽  
MP Manns ◽  
H Jaeschke ◽  
A Vogel
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Cholestatic Liver Injury

HGF/c-Met and IL-6/gp130 cooperatively regulate liver homeostasis and antibacterial signalling after bile-duct-ligation

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
A Giebeler ◽  
S Erschfeld ◽  
C Birchmeier ◽  
C Trautwein ◽  
KL Streetz
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Duct Ligation

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis

2012 ◽  
Vol 32 (9) ◽  
pp. 1342-1353 ◽  
Author(s):  
Erawan Borkham-Kamphorst ◽  
Sebastian Huss ◽  
Eddy Leur ◽  
Ute Haas ◽  
Ralf Weiskirchen
Keyword(s):  
Bile Duct ◽  
Gene Transfer ◽  
Liver Fibrosis ◽  
Bile Duct Ligation ◽  
Hepatocyte Apoptosis ◽  
Duct Ligation

Hepatic peroxiredoxin expression is increased in rats with chronic bile duct ligation

2000 ◽  
Vol 118 (4) ◽  
pp. A924
Author(s):  
Steven Douglas Colquhoun ◽  
Caroline A. Connelly ◽  
Lawrence Chen ◽  
Delai Zhao ◽  
Hungyi Shau
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Duct Ligation
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