microRNA‐96 protects pancreatic β‐cell function by targeting PAK1 in gestational diabetes mellitus

BioFactors ◽  
2018 ◽  
Vol 44 (6) ◽  
pp. 539-547 ◽  
Author(s):  
Lei Li ◽  
Shan Wang ◽  
Hongyan Li ◽  
Jipeng Wan ◽  
Qian Zhou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Β Cell Function

scholarly journals IL-34 causes inflammation and beta cell apoptosis and dysfunction in gestational diabetes mellitus

2019 ◽  
Vol 8 (11) ◽  
pp. 1503-1512 ◽  
Author(s):  
Chenghao Piao ◽  
Xiaojie Wang ◽  
Shiqiao Peng ◽  
Xinyu Guo ◽  
Hui Zhao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cord Blood ◽  
Cell Function ◽  
Positive Association ◽  
Beta Cell Apoptosis ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Β Cell Function

Objective Gestational diabetes mellitus (GDM) is characterized by glucose intolerance during gestation. It is associated with a series of maternal and foetal complications. Interleukin (IL)-34 is a recently discovered pro-inflammatory cytokine that functions as a ligand for colony-stimulating factor-1 receptor (CSF-1R). The contribution of IL-34 in the development of multiple chronic inflammatory diseases and autoimmune diseases has been recently discovered. The aim of this study was to evaluate whether IL-34 participates in the pathogenesis of GDM. Method A total of 120 women were enrolled in this study, which included 60 GDM patients and age- and sex-matched healthy pregnant women. The expression of IL-34 in serum, cord blood and placental tissues was analysed by ELISA and Western blot assays. The association between IL-34 levels and clinical features was also studied. We additionally evaluated the effect of recombinant mouse IL-34 (rmIL-34) on apoptosis and pancreatic β cell function. Results We found that IL-34 expression is highly increased in serum, cord blood and placental tissues in patients with GDM. In addition, there was a positive association between serum IL-34 and insulin resistance and glucose concentrations. Our data also revealed that IL-34 contributes to the apoptosis of pancreatic β cells in GDM caused by CSF-1R. Furthermore, functional studies found that IL-34 inhibited pancreatic β cell function and cell viability, while CSF-1R inhibitor blocked this effect. Conclusion IL-34 plays a crucial role in the development of GDM by targeting CSF-1R, insulin production and β cell function.

Glucagon stimulation test: assessment of β-cell function in gestational diabetes mellitus

1994 ◽  
Vol 56 (1) ◽  
pp. 27-30 ◽  
Author(s):  
M.L. Jacobs ◽  
S. Verhoog ◽  
W.-H. van der Linden ◽  
W.M. Huisman ◽  
H.C.S. Wallenburg ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cell Function ◽  
Stimulation Test ◽  
Glucagon Stimulation Test ◽  
Β Cell ◽  
Test Assessment ◽  
Β Cell Function

scholarly journals Molecular Modelling of Islet β-Cell Adaptation to Inflammation in Pregnancy and Gestational Diabetes Mellitus

2019 ◽  
Vol 20 (24) ◽  
pp. 6171 ◽  
Author(s):  
Petra I. Lorenzo ◽  
Alejandro Martín-Montalvo ◽  
Nadia Cobo Vuilleumier ◽  
Benoit R. Gauthier
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cell Function ◽  
Cell Mass ◽  
Late Pregnancy ◽  
Adverse Outcomes ◽  
Β Cell ◽  
Β Cell Function ◽  
Pax Family

Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late pregnancy, is currently one of the most common complications affecting pregnancy. The polygenic nature of GDM, together with the interplay between different genetic variants with nutritional and environmental factors has hindered the full understanding of the etiology of this disease. However, an important genetic overlap has been found with type 2 diabetes mellitus (T2DM) and, as in the case of T2DM, most of the identified loci are associated with β-cell function. Early detection of GDM and adequate interventions to control the maternal glycemia are necessary to avoid the adverse outcomes for both the mother and the offspring. The in utero exposure to the diabetic milieu predispose these children for future diseases, among them T2DM, originating a vicious circle implicated in the increased prevalence of both GDM and T2DM. The involvement of inflammatory processes in the development of GDM highlights the importance of pancreatic β-cell factors able to favor the adaptation processes required during gestation, concomitantly with the protection of the islets from an inflammatory milieu. In this regard, two members of the Pax family of transcription factors, PAX4 and PAX8, together with the chromatin remodeler factor HMG20A, have gained great relevance due to their involvement in β-cell mass adaptation together with their anti-inflammatory properties. Mutations in these factors have been associated with GDM, highlighting these as novel candidates for genetic screening analysis in the identification of women at risk of developing GDM.

scholarly journals High Calorie Intake Is Associated With Worsening Insulin Resistance and β-Cell Function in Hispanic Women After Gestational Diabetes Mellitus

Diabetes Care ◽  
2014 ◽  
Vol 37 (12) ◽  
pp. 3294-3300 ◽  
Author(s):  
Zhanghua Chen ◽  
Richard M. Watanabe ◽  
Daniel O. Stram ◽  
Thomas A. Buchanan ◽  
Anny H. Xiang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cell Function ◽  
Hispanic Women ◽  
Calorie Intake ◽  
Β Cell ◽  
Β Cell Function ◽  
High Calorie
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