Western equine encephalitis virus virus‐like particles from an insect cell‐baculovirus system elicit the strong immune responses in mice

2021 ◽  
pp. 2100008
Author(s):  
JinZhu Ma ◽  
HuaLei Wang ◽  
XueXing Zheng ◽  
HongXia Wu ◽  
SongTao Yang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Insect Cell ◽  
Encephalitis Virus ◽  
Virus Like Particles ◽  
Equine Encephalitis Virus ◽  
Western Equine Encephalitis Virus ◽  
Baculovirus System ◽  
Western Equine Encephalitis

scholarly journals Immune Responses in Mice Vaccinated with Virus-Like Particles of Western Equine Encephalitis Virus from an Insect Cell-Based Expression System

2021 ◽  
Author(s):  
Jinzhu Ma ◽  
Hualei Wang ◽  
Xuexing Zheng ◽  
Hongxia Wu Wu ◽  
Songtao Yang ◽  
...  
Keyword(s):  
Insect Cells ◽  
High Titer ◽  
Expression System ◽  
Encephalitis Virus ◽  
Effective Vaccine ◽  
Virus Like Particles ◽  
Equine Encephalitis Virus ◽  
Important Challenge ◽  
Western Equine Encephalitis Virus ◽  
Western Equine Encephalitis

Western equine encephalitis virus (WEEV) can cause lethal encephalitis in humans and equines and represents a serious public health threat in many countries. Therefore, development of efficient vaccines against WEEV remains an important challenge in the field of disease control. This study described for the first time successful production of WEEV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is very suitable for production of WEEV VLPs. The immune experiment herein in mice showed that the VLPs formulated with 206-adjuvant were responsible for the stronger-VLP-specific cellular immune response, and were able to induce the secretion of IL-2, IL-4, IFN-γ and production of high titer antibodies that can effectively neutralize the WEEV pseudoviruses. The WEEV VLPs from insect cells could provide a new, safe, non-replicating and effective vaccine candidate against WEEV infections.

scholarly journals Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model

Virology ◽  
2007 ◽  
Vol 360 (2) ◽  
pp. 454-460 ◽  
Author(s):  
Justin G. Julander ◽  
Venkatraman Siddharthan ◽  
Lawrence M. Blatt ◽  
Kristiina Schafer ◽  
Robert W. Sidwell ◽  
...  
Keyword(s):  
Virus Disease ◽  
Encephalitis Virus ◽  
Interferon Inducer ◽  
Hamster Model ◽  
Equine Encephalitis Virus ◽  
Western Equine Encephalitis Virus ◽  
Western Equine Encephalitis
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