scholarly journals Controlled release of neurotrophin-3 from fibrin-based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury

2009 ◽  
Vol 104 (6) ◽  
pp. 1207-1214 ◽  
Author(s):  
Philip J. Johnson ◽  
Stanley R. Parker ◽  
Shelly E. Sakiyama-Elbert
Keyword(s):  
Spinal Cord ◽  
Tissue Engineering ◽  
Spinal Cord Injury ◽  
Controlled Release ◽  
Tissue Engineering Scaffolds ◽  
Neurotrophin 3 ◽  
Cord Injury ◽  
Neural Fiber

Research progress and prospects of tissue engineering scaffolds for spinal cord injury repair and protection

2019 ◽  
Vol 14 (9) ◽  
pp. 887-898
Author(s):  
Zhanjun Ma ◽  
Yubao Lu ◽  
Yang Yang ◽  
Jing Wang ◽  
Xuewen Kang
Keyword(s):  
Spinal Cord ◽  
Tissue Engineering ◽  
Spinal Cord Injury ◽  
Research Progress ◽  
Comprehensive Treatment ◽  
Biological Factors ◽  
Tissue Engineering Scaffolds ◽  
Biological Scaffolds ◽  
Injury Repair ◽  
Cord Injury

Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tissue engineering has gradually replaced the single transplantation approach to become a focus of research that brings new opportunities for the clinical treatment of SCI.

Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury

2004 ◽  
Vol 98 (2) ◽  
pp. 281-294 ◽  
Author(s):  
Sara J Taylor ◽  
John W McDonald ◽  
Shelly E Sakiyama-Elbert
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Controlled Release ◽  
Fibrin Gels ◽  
Neurotrophin 3 ◽  
Cord Injury

Transplantation of collagen sponge-based three-dimensional neural stem cells cultured in the RCCS system facilitate locomotor functional recovery in spinal cord injury animals

2022 ◽  
Author(s):  
Jianwu Dai ◽  
Yunlong Zou ◽  
Yanyun Yin ◽  
Zhifeng Xiao ◽  
Yannan Zhao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Three Dimensional ◽  
Collagen Sponge ◽  
Cellular Functions ◽  
Cord Injury ◽  
Cells Cultured

Numerous studies have indicated that microgravity induces various changes in the cellular functions of neural stem cells (NSCs), and the use of microgravity to culture tissue engineering seed cells for...

scholarly journals Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Qi Han ◽  
Josue D. Ordaz ◽  
Nai-Kui Liu ◽  
Zoe Richardson ◽  
Wei Wu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Neurons ◽  
Enhanced Recovery ◽  
Neural Pathways ◽  
Locomotor Recovery ◽  
Neurotrophin 3 ◽  
Cord Injury ◽  
Dendritic Atrophy ◽  
Descending Projections

AbstractLocomotor function, mediated by lumbar neural circuitry, is modulated by descending spinal pathways. Spinal cord injury (SCI) interrupts descending projections and denervates lumbar motor neurons (MNs). We previously reported that retrogradely transported neurotrophin-3 (NT-3) to lumbar MNs attenuated SCI-induced lumbar MN dendritic atrophy and enabled functional recovery after a rostral thoracic contusion. Here we functionally dissected the role of descending neural pathways in response to NT-3-mediated recovery after a T9 contusive SCI in mice. We find that residual projections to lumbar MNs are required to produce leg movements after SCI. Next, we show that the spared descending propriospinal pathway, rather than other pathways (including the corticospinal, rubrospinal, serotonergic, and dopaminergic pathways), accounts for NT-3-enhanced recovery. Lastly, we show that NT-3 induced propriospino-MN circuit reorganization after the T9 contusion via promotion of dendritic regrowth rather than prevention of dendritic atrophy.

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