Duodenum- and spleen-preserving total pancreatectomy for end-stage chronic pancreatitis

2003 ◽  
Vol 90 (11) ◽  
pp. 1401-1408 ◽  
Author(s):  
N. Alexakis ◽  
P. Ghaneh ◽  
S. Connor ◽  
M. Raraty ◽  
R. Sutton ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
Spleen Preserving ◽  
End Stage

The Liverpool duodenum-and spleen-preserving near-total pancreatectomy can provide long-term pain relief in patients with end-stage chronic pancreatitis

2019 ◽  
Vol 404 (7) ◽  
pp. 831-840 ◽  
Author(s):  
A. R. G. Sheel ◽  
R. D. Baron ◽  
L. D. Dickerson ◽  
P. Ghaneh ◽  
F. Campbell ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pain Relief ◽  
Total Pancreatectomy ◽  
Spleen Preserving ◽  
End Stage

Role of total pancreatectomy in the treatment of patients with end-stage chronic pancreatitis

1995 ◽  
Vol 82 (10) ◽  
pp. 1409-1412 ◽  
Author(s):  
W. R. Fleming ◽  
R. C. N. Williamson
Keyword(s):  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
End Stage

Duodenum-and spleen-preserving total pancreatectomy (DPSPTP) for end-staged chronic pancreatitis: 20 years' experience from a single pancreatic centre

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S86-S87
Author(s):  
Andrea Sheel ◽  
Ryan Baron ◽  
Chris Halloran ◽  
Paula Ghaneh ◽  
Michael Raraty ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
Spleen Preserving

Duodenum-preserving total pancreatectomy for end stage chronic pancreatitis

1987 ◽  
Vol 74 (1) ◽  
pp. 35-39 ◽  
Author(s):  
M. A. Lambert ◽  
I. P. Linehan ◽  
R. C. G. Russell
Keyword(s):  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
End Stage

The feasibility of spleen-preserving pancreatectomy for end-stage chronic pancreatitis

2000 ◽  
Vol 179 (4) ◽  
pp. 294-297 ◽  
Author(s):  
Steven A White ◽  
Chris D Sutton ◽  
Simon Weymss-Holden ◽  
David P Berry ◽  
Cris Pollard ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Spleen Preserving ◽  
End Stage

scholarly journals Total Pancreatectomy for End-stage Chronic Pancreatitis

1978 ◽  
Vol 188 (3) ◽  
pp. 317-322 ◽  
Author(s):  
JOHN W. BRAASCH ◽  
LOUIS VITO ◽  
F. WARREN NUGENT
Keyword(s):  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
End Stage

119-OR: Total Pancreatectomy with Islet Autotransplantation in Diabetic and Prediabetic Patients with Intractable Chronic Pancreatitis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 119-OR
Author(s):  
PIOTR J. BACHUL ◽  
PETER BOREK ◽  
ROI ANTEBY ◽  
LINDSAY BASTO ◽  
LAURENCIA PEREA ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
Islet Autotransplantation

scholarly journals Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Péter J. Hegyi ◽  
Alexandra Soós ◽  
Emese Tóth ◽  
Attila Ébert ◽  
Viktória Venglovecz ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Morphological Changes ◽  
International Study ◽  
Study Data ◽  
Cross Sectional ◽  
Clinical Biomarkers ◽  
Stage Disease ◽  
Significant Difference ◽  
End Stage

AbstractChronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.

scholarly journals Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis

2012 ◽  
Vol 214 (4) ◽  
pp. 409-424 ◽  
Author(s):  
David E.R. Sutherland ◽  
David M. Radosevich ◽  
Melena D. Bellin ◽  
Bernard J. Hering ◽  
Gregory J. Beilman ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
Islet Autotransplantation

scholarly journals Antioxidant Therapy in Pancreatitis

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 657
Author(s):  
Lourdes Swentek ◽  
Dean Chung ◽  
Hirohito Ichii
Keyword(s):  
Oxidative Stress ◽  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
Current Status ◽  
Related Factor ◽  
Endocrine Dysfunction ◽  
Deep Dive ◽  
Pathway Activation ◽  
Advanced Therapies ◽  
And Oxidative Stress

Pancreatitis is pathologic inflammation of the pancreas characterized by acinar cell destruction and oxidative stress. Repeated pancreatic insults can result in the development of chronic pancreatitis, characterized by irreversible fibrosis of the pancreas and many secondary sequelae, ultimately leading to the loss of this important organ. We review acute pancreatitis, chronic pancreatitis, and pancreatitis-related complications. We take a close look at the pathophysiology with a focus on oxidative stress and how it contributes to the complications of the disease. We also take a deep dive into the evolution and current status of advanced therapies for management including dietary modification, antioxidant supplementation, and nuclear factor erythroid-2-related factor 2-Kelch-like ECH-associated protein 1(Nrf2-keap1) pathway activation. In addition, we discuss the surgeries aimed at managing pain and preventing further endocrine dysfunction, such as total pancreatectomy with islet auto-transplantation.

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