Determination of memantine in rat plasma by HPLC-fluorescence method and its application to study of the pharmacokinetic interaction between memantine and methazolamide

2011 ◽  
Vol 26 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Mohamed G. Hassan ◽  
Kamla M. Emara ◽  
Horria A. Mohamed ◽  
Hanaa M. Abdel-Wadood ◽  
Rie Ikeda ◽  
...  
Keyword(s):  
Pharmacokinetic Interaction ◽  
Rat Plasma ◽  
Fluorescence Method

High-throughput LC-MS/MS Method for Simultaneous Determination of Pantoprazole and Atorvastatin in Rat Plasma: Application to a Pharmacokinetic Interaction Study

2021 ◽  
Vol 22 ◽  
Author(s):  
Jian Le ◽  
Yuehua Liao ◽  
Shengni Li ◽  
Xiujuan Chen ◽  
Zhanying Hong
Keyword(s):  
Drug Interaction ◽  
Multiple Reaction Monitoring ◽  
Pharmacokinetic Interaction ◽  
Rat Plasma ◽  
Interaction Study ◽  
Triple Quadrupole Mass Spectrometer ◽  
Internal Standards ◽  
Spectrometric Data ◽  
Drug Drug Interaction

Background: Pantoprazole and atorvastatin are often used jointly in the clinic. The drug-drug interaction of pantoprazole and atorvastatin is worthy of being investigated. Objective: A highly rapid, sensitive, and selective LC-MS/MS method was developed for simultaneous quantification of pantoprazole and atorvastatin in rat plasma. Methods: Omeprazole and atorvastatin-d5 were used as the internal standards (ISs) of pantoprazole and atorvastatin, respectively. Simple protein precipitation was used to extract analytes from 50.0 μL plasma samples. Results: The chromatographic separation was achieved on a C18 column and the total chromatographic run time was 3.2 min. Acquisition of mass spectrometric data was performed on a triple-quadrupole mass spectrometer in multiple- reaction-monitoring (MRM) mode with an ESI source using the transition m/z 384→ 200 for pantoprazole and m/z 559.4→ 440.2 for atorvastatin, respectively. The method was validated over the concentration range of 20.0 ∼ 5000 ng/mL for pantoprazole and 1.00 ∼ 250 ng/mL for atorvastatin. All the validation results, including linearity, specificity, precision, accuracy, extraction recovery, matrix effect, and stability, met the acceptance criteria as per FDA guidelines. Conclusion: This method was successfully applied to a pharmacokinetic interaction study in Wistar rats. The results revealed significant evidence for the drug-drug interaction between pantoprazole and atorvastatin.

Simultaneous determination of Rivaroxaban and TAK-438 in rat plasma by LC–MS/MS: application to pharmacokinetic interaction study

Bioanalysis ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Libin Wang ◽  
Shouchang Gai ◽  
Xiaorui Zhang ◽  
Xiaohui Xu ◽  
Nan Gou ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Internal Standard ◽  
Pharmacokinetic Interaction ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Interaction Study ◽  
Significant Difference ◽  
Us Fda ◽  
First Time

Aim: A sensitive and reliable LC–MS/MS method has been established and validated to the quantitation of rivaroxaban (RIV) and TAK-438 in rat plasma using carbamazepine as internal standard. Results: The procedure of method validation was conducted according to the guidelines of EMA and US FDA. At the same time, the method was applied to pharmacokinetic interactions study between RIV and TAK-438 for the first time. When RIV and TAK-438 co-administration to rats, main pharmacokinetic parameters of TAK-438 like AUC(0-t), AUC(0-∞) and Cmax had statistically significant increase. The main pharmacokinetic parameters of RIV have no statistically significant difference (p > 0.05) when co-administered except for t1/2 (p < 0.01). Conclusion: The results indicated that drug–drug interactions occurred between RIV and TAK-438 when co-administered to rats.

Determination of glibenclamide and puerarin in rat plasma by UPLC–MS/MS: Application to their pharmacokinetic interaction study

Talanta ◽  
2013 ◽  
Vol 104 ◽  
pp. 109-115 ◽  
Author(s):  
Ning Li ◽  
Ying Deng ◽  
Dan Wang ◽  
Ying Qiao ◽  
Famei Li
Keyword(s):  
Pharmacokinetic Interaction ◽  
Rat Plasma ◽  
Interaction Study

Simultaneous determination of telmisartan and pitavastatin in rat plasma by UPLC–MS/MS: Application to pharmacokinetic interaction study

2016 ◽  
Vol 131 ◽  
pp. 373-379 ◽  
Author(s):  
Xi Chen ◽  
Bei Xu ◽  
Jian Yang ◽  
Juan Liu ◽  
Dailong Fang ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Pharmacokinetic Interaction ◽  
Rat Plasma ◽  
Interaction Study

Simultaneous Determination of Rivaroxaban and Enalapril in Rat Plasma by UPLC–MS/MS and Its Application to A Pharmacokinetic Interaction Study

2018 ◽  
Vol 44 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Shu Zheng ◽  
Shun-Bin Luo ◽  
Yi-Bin Mei ◽  
Jing Guo ◽  
Li-Jun Tong ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Pharmacokinetic Interaction ◽  
Rat Plasma ◽  
Interaction Study

Simultaneous determination of erlotinib and tamoxifen in rat plasma using UPLC–MS/MS: Application to pharmacokinetic interaction studies

2016 ◽  
Vol 1028 ◽  
pp. 100-110 ◽  
Author(s):  
Hadir M. Maher ◽  
Nourah Z. Alzoman ◽  
Shereen M. Shehata
Keyword(s):  
Simultaneous Determination ◽  
Pharmacokinetic Interaction ◽  
Rat Plasma ◽  
Interaction Studies
Sign in / Sign up

Export Citation Format

Share Document