Highly sensitive LC-MS/MS method for determination of galantamine in rat plasma: application to pharmacokinetic studies in rats

2014 ◽  
Vol 28 (12) ◽  
pp. 1633-1640 ◽  
Author(s):  
P. S. Suresh ◽  
Ramesh Mullangi ◽  
Sathesh Kumar Sukumaran
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Highly Sensitive

scholarly journals Highly Sensitive LC–MS-MS Method for the Determination of Tacrine in Rat Plasma: Application to Pharmacokinetic Studies in Rats

2015 ◽  
pp. bmv155
Author(s):  
Suresh Ponnayyan Sulochana ◽  
Vishnuvardh Ravichandiran ◽  
Ramesh Mullangi ◽  
Sathesh Kumar Sukumaran
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Highly Sensitive

LC Method for the Determination of Rhaponticin in Rat Plasma, Faeces and Urine for Application to Pharmacokinetic Studies

2011 ◽  
Vol 73 (5-6) ◽  
pp. 599-603 ◽  
Author(s):  
Yingyong Zhao ◽  
Lili Wang ◽  
Hua Miao ◽  
Charlene C. Ho ◽  
Jing Li ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies

scholarly journals An UPLC Method for Determination of Geraniin in Rat Plasma and its Application to Pharmacokinetic Studies

2017 ◽  
Vol 13 (4) ◽  
Author(s):  
Zhibiao Yi ◽  
Lin Ma ◽  
Baoqiang Wang ◽  
Wenxuan Cai ◽  
Zheng Xiang
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies

HIGHLY SENSITIVE LC-MS/MS METHOD FOR THE DETERMINATION OF CLOZAPINE IN RAT PLASMA: APPLICATION TO A PRECLINICAL PHARMACOKINETIC STUDY

2012 ◽  
Vol 35 (20) ◽  
pp. 2873-2883 ◽  
Author(s):  
Sandra Elisa Haas ◽  
Liberato Brum ◽  
Cristiane de Andrade ◽  
Francine Johansson Azeredo ◽  
Maiara Pigatto ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive

HPLC Determination of Esculin and Esculetin in Rat Plasma for Pharmacokinetic Studies

2015 ◽  
Vol 53 (8) ◽  
pp. 1322-1327 ◽  
Author(s):  
Shaheed Ur Rehman ◽  
In Sook Kim ◽  
Ki Sung Kang ◽  
Hye Hyun Yoo
Keyword(s):  
Rat Plasma ◽  
Hplc Determination ◽  
Pharmacokinetic Studies

scholarly journals Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Hyun-moon Back ◽  
Byungjeong Song ◽  
Jung-woo Chae ◽  
Hwi-yeol Yun ◽  
Jin Yeul Ma ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Oral Administration ◽  
High Performance ◽  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Chemical Marker ◽  
Chromatography Tandem Mass Spectrometry ◽  
Accuracy And Precision ◽  
Liquid Chromatography Tandem Mass

KIOM-MA128 is a novel Korean herbal medicine with antiatopic, anti-inflammatory, and antiasthmatic effects. Matrine is thought to be a potential chemical marker of KIOM-MA128, but pharmacokinetic studies on KIOM-MA128 had not been performed. This study describes a simple and rapid method using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to determine the concentration of matrine in rats plasma after administration of KIOM-MA128. The isocratic mobile phase consisted of methanol and distilled water, and the flow rate was 0.15 mL/min. The accuracy and precision of the assay, as well as stability tests, were performed in accordance with FDA regulations for the validation of bioanalytical methods. The half-life andTmaxof matrine after administration of KIOM-MA128 were 4.29 ± 2.20 h and 1.8 ± 1.23 h, respectively.CmaxandAUCinfof matrine after administration of KIOM-MA128 at 4 g/kg and 8 g/kg were 595.10 ± 182.91 ng/mL, 5336.77 ± 1503.84 ng/mL·h and 850.46 ± 120 ng/mL, 9583.10 ± 888.92 ng/mL·h, respectively. The validated method was successfully applied to a pharmacokinetic study in rats after oral administration of KIOM-MA128.

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