Simultaneous determination of the novel tyrosine kinase inhibitor meditinib and its active metabolite demethylation meditinib in monkey plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies

2015 ◽  
Vol 29 (8) ◽  
pp. 1259-1266
Author(s):  
Feng Liang ◽  
Qi Kong ◽  
Yongqi Guo ◽  
Yu Wang ◽  
Dejie Sun ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Active Metabolite ◽  
Kinase Inhibitor ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
The Novel ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Monkey Plasma

scholarly journals A simple sensitive UFLC-MS/MS method for the simultaneous quantification of artesunate, dihydroartemisinin and quercetin in rat plasma and its application to pharmacokinetic studies

RSC Advances ◽  
2019 ◽  
Vol 9 (71) ◽  
pp. 41794-41802
Author(s):  
Nethravathi Puttappa ◽  
Karthik Yamjala ◽  
Narenderan S. T. ◽  
Suresh Kumar Raman ◽  
Gowthamarajan Kuppusamy ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Active Metabolite ◽  
Rat Plasma ◽  
Simultaneous Estimation ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Simultaneous Quantification ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

An ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was developed for the simultaneous estimation of artesunate (ART), dihydroartemisinin (DHA, an active metabolite of ART) and quercetin (QRT) in rat plasma.

Enantioselective determination of lercanidipine in human plasma for pharmacokinetic studies by normal-phase liquid chromatography–tandem mass spectrometry

2003 ◽  
Vol 796 (2) ◽  
pp. 429-437 ◽  
Author(s):  
Valquiria Aparecida Polisel Jabor ◽  
Eduardo Barbosa Coelho ◽  
Demian Rocha Ifa ◽  
Pierina Sueli Bonato ◽  
Neife Aparecida Guinaim dos Santos ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Normal Phase ◽  
Pharmacokinetic Studies ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Phase Liquid
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