A reliable LC-MS/MS method for the quantification of N -acetyl-p -benzoquinoneimine, acetaminophen glutathione and acetaminophen glucuronide in mouse plasma, liver and kidney: Method validation and application to a pharmacokinetic study

2018 ◽  
Vol 32 (11) ◽  
pp. e4331 ◽  
Author(s):  
Xiqian Zhang ◽  
Ruina Li ◽  
Wenya Hu ◽  
Jin Zeng ◽  
Xuehua Jiang ◽  
...  
Keyword(s):  
Method Validation ◽  
Pharmacokinetic Study ◽  
Mouse Plasma ◽  
Liver And Kidney ◽  
Acetaminophen Glucuronide

Performance of tiloronoxim and tilorone determination in human blood by HPLC–MS/MS: Method validation, uncertainty assessment and its application to a pharmacokinetic study

2010 ◽  
Vol 878 (3-4) ◽  
pp. 492-496 ◽  
Author(s):  
Xianhua Zhang ◽  
Jingli Duan ◽  
Suodi Zhai ◽  
Yiheng Yang ◽  
Li Yang
Keyword(s):  
Method Validation ◽  
Human Blood ◽  
Pharmacokinetic Study ◽  
Uncertainty Assessment

A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: application to mice pharmacokinetic study

2021 ◽  
pp. 123025
Author(s):  
Huimei Fu ◽  
Lijuan Chu ◽  
He Jiao ◽  
Longyi Lin ◽  
Youping Liu ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Pharmacokinetic Study ◽  
Mouse Plasma ◽  
Highly Sensitive

scholarly journals A new selective, and sensitive method for the determination of lixivaptan, a vasopressin 2 (V2)-receptor antagonist, in mouse plasma and its application in a pharmacokinetic study

2018 ◽  
Vol 16 (1) ◽  
pp. 614-620
Author(s):  
Haitham Alrabiah ◽  
Mohammed Abunassif ◽  
Sabry Attia ◽  
Gamal Abdel-Hafiz Mostafa
Keyword(s):  
Receptor Antagonist ◽  
Pharmacokinetic Study ◽  
Limit Of Detection ◽  
Internal Standard ◽  
Hplc Method ◽  
Maximum Plasma ◽  
Mouse Plasma ◽  
V2 Receptor ◽  
V2 Receptor Antagonist

AbstractA new, selective and sensitive HPLC method for the determination of lixivaptan, an oral selective vasopressin 2 (V2)-receptor antagonist, was investigated and validated. A Waters symmetry C18 column was used as a stationary phase in isocratic elution mode using a mobile phase composed of KH2PO4 (100 mM)-acetonitrile (40: 60, v/v) at a flow rate of 1.5 mL min-1. Diclofenac was used as the internal standard (IS). Lixivaptan and the IS were extracted from plasma by protein precipitation and were detected at 260 nm. Lixivaptan and diclofenac were eluted at 3.6 and 6.2 min, respectively. The developed method showed good linearity over the calibration range of 50 -1000 ng mL-1 with a lower limit of detection of 16.5 ng mL-1. The extraction percentage of lixivaptan in the mouse plasma was in the range of 88.88 - 114.43%, which indicates acceptable extraction. The aforementioned method was validated according to guidelines of the International Council on Harmonization (ICH). The intra- and inter-day coefficients of variation did not exceed 5.5%. This method was presented to be simple, sensitive, and accurate and was successfully adapted in a pharmacokinetic study of the profile of lixivaptan in mouse plasma. A mean maximum plasma concentration of lixivaptan of 113.82 ng mL-1 was achieved in 0.5 h after oral administration of a 10 mg kg-1 dose in mouse as determined using the developed method.

Validated HPLC method for simultaneous quantification of mutant IDH1/2 inhibitors (enasidenib, ivosidenib and vorasidenib) in mouse plasma: Application to a pharmacokinetic study

2019 ◽  
Author(s):  
Ashok Zakkula ◽  
Sreekanth Dittakavi ◽  
Malika Muskan Maniyar ◽  
Naveem Syed ◽  
Suresh P. Sulochana ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Hplc Method ◽  
Mouse Plasma ◽  
Simultaneous Quantification ◽  
Mutant Idh1

A simple and sensitive LC/MS/MS assay for 7-ethyl-10-hydroxycamptothecin (SN-38) in mouse plasma and tissues: application to pharmacokinetic study of liposome entrapped SN-38 (LE-SN38)

2005 ◽  
Vol 37 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Sumsullah Khan ◽  
Ateeq Ahmad ◽  
Wei Guo ◽  
Yue-Fen Wang ◽  
Aqel Abu-Qare ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Mouse Plasma

scholarly journals Pharmacokinetic study of the enterohepatic circulation of acetaminophen glucuronide in rats.

1984 ◽  
Vol 7 (11) ◽  
pp. 811-819 ◽  
Author(s):  
NOBUTOSHI WATARI ◽  
MASAAKI HANAWA ◽  
MASUAKI IWAI ◽  
NOBUYOSHI KANENIWA
Keyword(s):  
Pharmacokinetic Study ◽  
Enterohepatic Circulation ◽  
Acetaminophen Glucuronide
Sign in / Sign up

Export Citation Format

Share Document