Quantification of serum thyroid hormones using tandem mass spectrometry in patients with Down syndrome

2021 ◽  
Author(s):  
Reiko Iwano ◽  
Machiko Toki ◽  
Junko Hanakawa ◽  
Yumi Asakura ◽  
Masanori Adachi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Down Syndrome ◽  
Tandem Mass Spectrometry ◽  
Thyroid Hormones ◽  
Tandem Mass ◽  
Serum Thyroid Hormones

The development of a peptide SRM-based tandem mass spectrometry assay for prenatal screening of Down syndrome

2012 ◽  
Vol 75 (11) ◽  
pp. 3248-3257 ◽  
Author(s):  
Wendy Heywood ◽  
Darrell Wang ◽  
Tracey E. Madgett ◽  
Neil D. Avent ◽  
Simon Eaton ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Down Syndrome ◽  
Tandem Mass Spectrometry ◽  
Prenatal Screening ◽  
Tandem Mass ◽  
Mass Spectrometry Assay

scholarly journals Correlations of Free Thyroid Hormones Measured by Tandem Mass Spectrometry and Immunoassay with Thyroid-Stimulating Hormone across 4 Patient Populations

2009 ◽  
Vol 55 (7) ◽  
pp. 1380-1388 ◽  
Author(s):  
Jacqueline Jonklaas ◽  
Natasa Kahric-Janicic ◽  
Offie P Soldin ◽  
Steven J Soldin
Keyword(s):  
Mass Spectrometry ◽  
Thyroid Hormone ◽  
Tandem Mass Spectrometry ◽  
Thyroid Hormones ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Tandem Mass ◽  
Free Triiodothyronine ◽  
Free Thyroid Hormones ◽  
Free Thyroid Hormone

Abstract Background: Accurate measurement of free thyroid hormones is important for managing thyroid disorders. Ultrafiltration liquid chromatography tandem mass spectrometry (LC-MS/MS) can reliably measure the concentrations of small molecules, including thyroid hormones. Our study was designed to compare free thyroid hormone measurements performed with immunoassay and LC-MS/MS. Methods: We studied the performance of LC-MS/MS in 4 different populations comprising pediatric patients, euthyroid adults, and healthy nonpregnant and pregnant women. The samples obtained from each population numbered 38, 200, 28, and 128, respectively. Free thyroxine, free triiodothyronine, and thyroid-stimulating hormone (TSH) concentrations were documented. Results: LC-MS/MS measurement of free thyroid hormones provided better correlation with log-transformed serum TSH in each population and also the populations combined. The correlations between free thyroxine measured by LC-MS/MS and log TSH in the pediatric outpatients and healthy adults were −0.90 and −0.77, respectively. The correlations for immunoassay were −0.82 and −0.48. The correlations between free triiodothyronine measured by LC-MS/MS and TSH for both pediatric and healthy adult populations were −0.72 and −0.68, respectively. Conclusions: Free thyroid hormone concentrations measured by LC-MS/MS correlate to a greater degree with log TSH values compared to concentrations measured by immunoassay. This correlation was maintained across the patient populations we studied and may reflect the accuracy and specificity of LC-MS/MS. The superior ability of LC-MS/MS to enable documentation of the well-known thyroid hormone–TSH relationship supports the use of this measurement technique in a variety of clinical situations.

scholarly journals Correlation between Serum Levels of 3,3ʹ,5ʹ-Triiodothyronine and Thyroid Hormones Measured by Liquid Chromatography-Tandem Mass Spectrometry and Immunoassay

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0138864 ◽  
Author(s):  
Hiroyuki Sakai ◽  
Hidenori Nagao ◽  
Mamoru Sakurai ◽  
Takako Okumura ◽  
Yoshiyuki Nagai ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Thyroid Hormones ◽  
Serum Levels ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

scholarly journals Correction: Correlation between Serum Levels of 3,3ʹ,5ʹ-Triiodothyronine and Thyroid Hormones Measured by Liquid Chromatography-Tandem Mass Spectrometry and Immunoassay

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159169 ◽  
Author(s):  
Hiroyuki Sakai ◽  
Hidenori Nagao ◽  
Mamoru Sakurai ◽  
Takako Okumura ◽  
Yoshiyuki Nagai ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Thyroid Hormones ◽  
Serum Levels ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass
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