scholarly journals Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis

2021 ◽  
Author(s):  
Yong Mou ◽  
Guo‐Rao Wu ◽  
Qi Wang ◽  
Ting Pan ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pulmonary Fibrosis ◽  
Targeted Delivery ◽  
Mecp2 Gene

scholarly journals Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma

2021 ◽  
Vol 6 (5) ◽  
pp. 1330-1340
Author(s):  
Yu Xia ◽  
Guoyi Tang ◽  
Yi Chen ◽  
Changbing Wang ◽  
Min Guo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Targeted Delivery ◽  
Therapeutic Response ◽  
Sox2 Gene

scholarly journals Identification of Pathologic Fibroblasts with the Highest Level of ECM Gene Expression and Migratory Phenotype in Pulmonary Fibrosis

2020 ◽  
Author(s):  
T. Tsukui ◽  
K.-H. Sun ◽  
J.R. Wilson-Kanamori ◽  
J.B. Wetter ◽  
L.A. Hazelwood ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pulmonary Fibrosis ◽  
Migratory Phenotype

scholarly journals PDGFRα and αSMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis

2020 ◽  
Vol 318 (4) ◽  
pp. L684-L697 ◽  
Author(s):  
Valentina Biasin ◽  
Slaven Crnkovic ◽  
Anita Sahu-Osen ◽  
Anna Birnhuber ◽  
Elie El Agha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pulmonary Fibrosis ◽  
Expression Profiles ◽  
Smooth Muscle Actin ◽  
Gene Expression Profiles ◽  
Mesenchymal Cell ◽  
Cellular Heterogeneity ◽  
Cell Populations ◽  
Variable Expression ◽  
Distinct Gene

Pulmonary fibrosis is characterized by pronounced collagen deposition and myofibroblast expansion, whose origin and plasticity remain elusive. We utilized a fate-mapping approach to investigate α-smooth muscle actin (αSMA)+ and platelet-derived growth factor receptor α (PDGFRα)+ cells in two lung fibrosis models, complemented by cell type-specific next-generation sequencing and investigations on human lungs. Our data revealed that αSMA+ and PDGFRα+ cells mark two distinct mesenchymal lineages with minimal transdifferentiation potential during lung fibrotic remodeling. Parenchymal and perivascular fibrotic regions were populated predominantly with PDGFRα+ cells expressing collagen, while αSMA+ cells in the parenchyma and vessel wall showed variable expression of collagen and the contractile protein desmin. The distinct gene expression profile found in normal conditions was retained during pathologic remodeling. Cumulatively, our findings identify αSMA+ and PDGFRα+ cells as two separate lineages with distinct gene expression profiles in adult lungs. This cellular heterogeneity suggests that anti-fibrotic therapy should target diverse cell populations.

Elastin Gene Expression is Upregulated During Pulmonary Fibrosis

1999 ◽  
Vol 40 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Catherine R. Hoff ◽  
Doug R. Perkins ◽  
Jeffrey M. Davidson
Keyword(s):  
Gene Expression ◽  
Pulmonary Fibrosis ◽  
Elastin Gene

scholarly journals Cocaine hijacks sigma‐1 receptors from the ER to the nuclear membrane to interact with lamina A/C: Effect on MeCP2 gene expression

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Chien-Ying Chuang ◽  
Shang-Yi Tsai ◽  
Teruo Hayashi ◽  
Jan-Jong Hung ◽  
Wen-Chang Chang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nuclear Membrane ◽  
Mecp2 Gene ◽  
Sigma 1
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