Effect of aeration and agitation on extractive fermentation of clavulanic acid by using aqueous two-phase system

2016 ◽  
Vol 32 (6) ◽  
pp. 1444-1452 ◽  
Author(s):  
Daniela A. Viana Marques ◽  
Valéria C. Santos-Ebinuma ◽  
Adalberto Pessoa-Júnior ◽  
Ana L. F. Porto ◽  
Beatriz Rivas Torres ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Phase System ◽  
Extractive Fermentation ◽  
Two Phase ◽  
Aqueous Two Phase System

Extractive fermentation of clavulanic acid by Streptomyces DAUFPE 3060 using aqueous two-phase system

2010 ◽  
Vol 27 (1) ◽  
pp. 95-103 ◽  
Author(s):  
D. A. Viana Marques ◽  
A. Pessoa-Júnior ◽  
J. L. Lima-Filho ◽  
A. Converti ◽  
P. Perego ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Phase System ◽  
Extractive Fermentation ◽  
Two Phase ◽  
Aqueous Two Phase System

scholarly journals Stability of clavulanic acid in PEG/citrate and liquid–liquid extraction in aqueous two-phase system

2014 ◽  
Vol 375 ◽  
pp. 104-109 ◽  
Author(s):  
M.N. Carneiro-da-Cunha ◽  
K.P.S. Souza ◽  
A.M.O. Mota ◽  
J.A. Teixeira ◽  
C.S. Porto ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Liquid Extraction ◽  
Phase System ◽  
Two Phase ◽  
Aqueous Two Phase System ◽  
Liquid Liquid Extraction

Extractive fermentation for process integration of protease production by Aspergillus tamarii Kita UCP1279 and purification by PEG-Citrate Aqueous Two-Phase System

2021 ◽  
pp. 1-8
Author(s):  
Raniele Oliveira Alves ◽  
Rodrigo Lira de Oliveira ◽  
Osmar Soares da Silva ◽  
Ana Lúcia Figueiredo Porto ◽  
Camila Souza Porto ◽  
...  
Keyword(s):  
Process Integration ◽  
Protease Production ◽  
Phase System ◽  
Extractive Fermentation ◽  
Two Phase ◽  
Aspergillus Tamarii ◽  
Aqueous Two Phase System

scholarly journals Separation of clavulanic acid from fermented broth of amino acids by an aqueous two-phase system and ion exchange adsorption

2009 ◽  
Vol 25 ◽  
pp. S181 ◽  
Author(s):  
M. Barboza ◽  
C. Silva ◽  
M. Cuel ◽  
V. Barreto ◽  
C.O. Hokka
Keyword(s):  
Amino Acids ◽  
Ion Exchange ◽  
Clavulanic Acid ◽  
Phase System ◽  
Two Phase ◽  
Aqueous Two Phase System ◽  
Exchange Adsorption ◽  
Fermented Broth

Enhanced production of lactic acid through the use of a novel aqueous two-phase system as an extractive fermentation system

1996 ◽  
Vol 45 (6) ◽  
pp. 737-743 ◽  
Author(s):  
J. Planas ◽  
P. Ra˚dström ◽  
F. Tjerneld ◽  
B. Hahn-Hägerdal
Keyword(s):  
Lactic Acid ◽  
Phase System ◽  
Extractive Fermentation ◽  
Two Phase ◽  
Fermentation System ◽  
Aqueous Two Phase System ◽  
Enhanced Production

Intensification of β-glucosidase enzyme production from Aspergillus niger using extractive fermentation with an aqueous two-phase system

2017 ◽  
Vol 6 (4) ◽  
Author(s):  
Avinash B. Dhage ◽  
Virendra K. Rathod
Keyword(s):  
Aspergillus Niger ◽  
Wheat Bran ◽  
Enzyme Production ◽  
Phase System ◽  
Extractive Fermentation ◽  
Two Phase ◽  
Aqueous Two Phase System ◽  
Main Substrate

AbstractAn extractive fermentation approach in an aqueous two-phase system (ATPS) with wheat bran as a main substrate was used in this study to intensify the production of β-glucosidase enzyme (EC 3.2.1.21) from

scholarly journals Extractive Fermentation for Recovery of Bacteriocin-Like Inhibitory Substances Derived from Lactococcus lactis Gh1 Using PEG2000/Dextran T500 Aqueous Two-Phase System

Fermentation ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 257
Author(s):  
Roslina Jawan ◽  
Sahar Abbasiliasi ◽  
Joo Shun Tan ◽  
Murni Halim ◽  
Shuhaimi Mustafa ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Continuous Production ◽  
Scale Up ◽  
Downstream Processing ◽  
Sustainable Growth ◽  
Phase System ◽  
Extractive Fermentation ◽  
Cell Cultivation ◽  
Two Phase ◽  
Aqueous Two Phase System

This work aimed to optimize the parameters affecting partitioning of a bacteriocin-like inhibitory substances (BLIS) from Lactococcus lactis Gh1 in extractive fermentation using polyethylene glycol (PEG)/dextran aqueous two-phase system (ATPS). This system was developed for the simultaneous cell cultivation and downstream processing of BLIS. Results showed that the molecular weight of PEG, PEG concentration, and dextran T500 affect the partition coefficient (K), purification factor (PF), and yield of BLIS partitioning. ATPS composed of 10% (w/w) PEG2000 and 8% (w/w) dextran T500, provided the greatest conditions for the extractive BLIS production. The K (1.00 ± 0.16), PF (2.92 ± 0.37) and yield (77.24 ± 2.81%) were increased at selected orbital speed (200 rpm) and pH (pH 7). Sustainable growth of the cells in the bioreactor and repeated fermentation up to the eighth extractive batch were observed during the scale up process, ensuring a continuous production and purification of BLIS. Hence, the simplicity and effectiveness of ATPS in the purification of BLIS were proven in this study.

Recovery of clavulanic acid from an aqueous two-phase system by ion-exchange resin

2009 ◽  
Author(s):  
C. Sacardo da Silva ◽  
V. O. Barreto ◽  
E. Bavarotti ◽  
G. Youssef Rodriguez ◽  
C. Osamu Hokka ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Clavulanic Acid ◽  
Exchange Resin ◽  
Ion Exchange Resin ◽  
Phase System ◽  
Two Phase ◽  
Aqueous Two Phase System
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