scholarly journals Transcriptional suppression of CD8 + T cell exhaustion for improving T cell immunotherapy

2021 ◽  
Author(s):  
Xue Yang ◽  
Bingjing Wang ◽  
Xuetao Cao
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Transcriptional Suppression ◽  
Cell Immunotherapy ◽  
T Cell Immunotherapy

scholarly journals The Potential of T Cell Factor 1 in Sustaining CD8+ T Lymphocyte-Directed Anti-Tumor Immunity

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 515
Author(s):  
Sungmin Jung ◽  
Jea-Hyun Baek
Keyword(s):  
T Cell ◽  
Tumor Immunity ◽  
T Lymphocyte ◽  
Critical Role ◽  
Cd8 T Cell ◽  
Immune Checkpoint Blockade ◽  
Viral Escape ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
T Cell Factor

T cell factor 1 (TCF1) is a transcription factor that has been highlighted to play a critical role in the promotion of T cell proliferation and maintenance of cell stemness in the embryonic and CD8+ T cell populations. The regulatory nature of TCF1 in CD8+ T cells is of great significance, especially within the context of T cell exhaustion, which is linked to the tumor and viral escape in pathological contexts. Indeed, inhibitory signals, such as programmed cell death 1 (PD-1) and cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4), expressed on exhausted T lymphocytes (TEX), have become major therapeutic targets in immune checkpoint blockade (ICB) therapy. The significance of TCF1 in the sustenance of CTL-mediated immunity against pathogens and tumors, as well as its recently observed necessity for an effective anti-tumor immune response in ICB therapy, presents TCF1 as a potentially significant biomarker and/or therapeutic target for overcoming CD8+ T cell exhaustion and resistance to ICB therapy. In this review, we aim to outline the recent findings on the role of TCF1 in T cell development and discuss its implications in anti-tumor immunity.

scholarly journals CD8+T Cell Exhaustion During Persistent Viral Infection is Regulated Independently of the Virus-Specific T Cell Receptor

2013 ◽  
Vol 42 (3) ◽  
pp. 204-220 ◽  
Author(s):  
Stephanie R. Jackson ◽  
Melissa M. Berrien-Elliott ◽  
Jennifer M. Meyer ◽  
E. John Wherry ◽  
Ryan M. Teague
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
T Cell Receptor ◽  
Cd8 T Cell ◽  
Cell Receptor ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Persistent Viral Infection

scholarly journals Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC

2018 ◽  
Vol 9 (5) ◽  
Author(s):  
Jie Ji ◽  
Yin Yin ◽  
Huanyu Ju ◽  
Xiaoliang Xu ◽  
Wei Liu ◽  
...  
Keyword(s):  
T Cell ◽  
Nuclear Translocation ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Non Coding Rna ◽  
Long Non Coding Rna

O032 Timing and magnitude of Type I interferon responses by distinct viral sensors impact CD8 T cell exhaustion and chronic infection

Cytokine ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 512
Author(s):  
Y. Wang ◽  
M. Swiecki ◽  
M. Cella ◽  
G. Alber ◽  
R.D. Schreiber ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Infection ◽  
Type I Interferon ◽  
Cd8 T Cell ◽  
Type I ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Interferon Responses

scholarly journals Kupffer Cells Support Hepatitis B Virus–Mediated CD8+ T Cell Exhaustion via Hepatitis B Core Antigen–TLR2 Interactions in Mice

2015 ◽  
Vol 195 (7) ◽  
pp. 3100-3109 ◽  
Author(s):  
Min Li ◽  
Rui Sun ◽  
Long Xu ◽  
Wenwei Yin ◽  
Yongyan Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Kupffer Cells ◽  
Cd8 T Cell ◽  
Core Antigen ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
B Virus ◽  
Hepatitis B Core Antigen
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