Breast cyst fluid heparan sulphate is distinctivelyN-sulphated depending on apocrine or flattened type

2015 ◽  
Vol 33 (3) ◽  
pp. 128-133 ◽  
Author(s):  
Ferdinando Mannello ◽  
Francesca Maccari ◽  
Daniela Ligi ◽  
Martina Santi ◽  
Francesco Gatto ◽  
...  
Keyword(s):  
Heparan Sulphate ◽  
Cyst Fluid ◽  
Breast Cyst Fluid ◽  
Breast Cyst

Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy

1994 ◽  
Vol 1 (2) ◽  
pp. 49-55 ◽  
Author(s):  
I Számel ◽  
B Budai ◽  
K Daubner ◽  
J Kralovánszky ◽  
Sz Ottó ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sex Steroids ◽  
Linear Regression Analysis ◽  
Cyst Fluid ◽  
Type I ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Apocrine Metaplasia ◽  
Endocrine Parameters

ABSTRACT Gross cystic disease (GCD) of the breast may be associated with a higher risk for the development of breast cancer. High levels of sex steroids, steroid hormone precursors, prolactin and cations have been found in breast cyst fluid (BCF) by several investigators. Accordingly, endocrine parameters and the cationic composition of BCF may be considered as useful characteristics to follow patients bearing macrocysts. In this study we have investigated the concentrations of estradiol (E2), progesterone, testosterone, dehydroepiandrosterone (DHA) and DHA-3-sulfate (DHA-S), prolactin, potassium (K+) and sodium (Na+) in BCF aspirated from 99 women. The mean age of the patients was 49.8 years (range 32-58). The hormone levels were measured by RIA methods; K+ and Na+ were determined by flame photometry. Estradiol, progesterone, testosterone, DHA, DHA-S, prolactin and K+ showed significant accumulation in the BCF compared with their respective serum values. The K+/Na+ ratio proved to be useful in dividing cysts into type I (≥1), type II (<1 but ≥0.1) and type III (<0.1) subgroups. For type I BCF, higher DHA, DHA-S and prolactin concentrations were detected. Linear regression analysis established a highly significant (P<0.001) correlation between the concentrations of E2 and DHA-S (r=0.686), and also between testosterone and DHA-S (r=0.711). These findings indicate that type I BCF might be a marker for 'active' GCD of the breast, and suggest that it may be associated with an increased breast cancer risk, since this group of patients is supposed to have cysts with apocrine metaplasia. It is suggested therefore that when BCF is aspirated, sex steroids, steroid precursors and cations should be routinely measured, and women with type I cysts should be regularly examined.

Estroe-3-Sulfate in Human Breast Cyst Fluid

1990 ◽  
Vol 595 (1 Steroid Forma) ◽  
pp. 464-466 ◽  
Author(s):  
F. Orlandi ◽  
P. Caraci ◽  
B. Puligheddu ◽  
M. Torta ◽  
L. Dogliotti ◽  
...  
Keyword(s):  
Cyst Fluid ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Breast Cyst

Apocrine cells in breast cyst fluid and their relationship to cyst type: A morphometric Study

1988 ◽  
Vol 24 (4) ◽  
pp. 597-602 ◽  
Author(s):  
Donatella Beccati ◽  
Nadia Grilli ◽  
Patrizia Schincaglia ◽  
Carlo Naldoni ◽  
Licia Tavolazzi ◽  
...  
Keyword(s):  
Type A ◽  
Cyst Fluid ◽  
Morphometric Study ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Cyst Type

Catecholestrogen Content and Ratios in Breast Cyst Fluid

1990 ◽  
Vol 595 (1 Steroid Forma) ◽  
pp. 455-458
Author(s):  
O. M. Granata ◽  
F. Arcuri ◽  
E. Fecarotta ◽  
G. Brignone ◽  
L. Blasi ◽  
...  
Keyword(s):  
Cyst Fluid ◽  
Breast Cyst Fluid ◽  
Breast Cyst

Menstrual cycle-dependent variations of breast cyst fluid proteins and sex steroid receptors in the normal human breast

Cancer ◽  
1983 ◽  
Vol 51 (7) ◽  
pp. 1297-1302 ◽  
Author(s):  
John S. Silva ◽  
Gregory S. Georgiade ◽  
William G. Dilley ◽  
Kenneth S. McCarty ◽  
Samuel A. Wells ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Steroid Receptors ◽  
Cyst Fluid ◽  
Sex Steroid ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Normal Human Breast ◽  
Normal Human ◽  
Cycle Dependent

Presence and Distribution of Growth Factors in Breast Cyst Fluid

1996 ◽  
Vol 784 (1 Challenges an) ◽  
pp. 542-549 ◽  
Author(s):  
S. ZANARDI ◽  
F. PENSA ◽  
R. TORRISI ◽  
V. DE FRANCHIS ◽  
A. BARRECA ◽  
...  
Keyword(s):  
Growth Factors ◽  
Cyst Fluid ◽  
Breast Cyst Fluid ◽  
Breast Cyst

scholarly journals Human Glandular Kallikrein in Breast Milk, Amniotic Fluid, and Breast Cyst Fluid

1999 ◽  
Vol 45 (10) ◽  
pp. 1774-1780 ◽  
Author(s):  
Angeliki Magklara ◽  
Andreas Scorilas ◽  
Carlos López-Otín ◽  
Francisco Vizoso ◽  
Alvaro Ruibal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amniotic Fluid ◽  
Biological Fluids ◽  
Cyst Fluid ◽  
Cystic Disease ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Glandular Kallikrein ◽  
Female Breast

Abstract Background: Human glandular kallikrein (hK2) belongs to the serine protease family of enzymes and has high sequence homology with prostate-specific antigen (PSA). The physiological role of hK2 has not as yet been determined, but there is evidence that it can regulate the proteolytic activity of PSA through processing and activating pro-PSA, an inactive precursor. Thus, it is conceivable that these two secreted proteins may coexist in biological fluids. Currently, hK2 is considered an androgen-regulated and prostate-specific protein. Recently, it has been demonstrated that hK2 is expressed in the breast cancer cell line T-47D after stimulation by steroid hormones, and we reported that hK2 can be detected in a subset of breast tumor extracts. These data suggest that hK2 may be expressed in tissues other than the prostate, such as those in which PSA has already been detected. Because hK2 is a secreted protein, it may be present in various biological fluids. Methods: We analyzed milk samples from lactating women, amniotic fluid from pregnant women, and breast cyst fluid from patients with gross breast cystic disease, using a highly sensitive and specific immunoassay for hK2. Results: hK2 was present in all three biological fluids. We suggest that the female breast may produce hK2 and provide evidence that hK2 may have value as an additional marker for the discrimination between type I and type II breast cysts. Conclusions: The female breast produces hK2 in addition to PSA. More studies are necessary to establish the role of this kallikrein in nondiseased breast, gross breast cystic disease, and breast cancer.

Biochemistry of Breast Cyst Fluid.

1990 ◽  
Vol 586 (1 Biochemistry) ◽  
pp. 17-28 ◽  
Author(s):  
L. DOGLIOTTI ◽  
F. ORLANDI ◽  
P. CARACI ◽  
B. PULIGHEDDU ◽  
M. TORTA ◽  
...  
Keyword(s):  
Cyst Fluid ◽  
Breast Cyst Fluid ◽  
Breast Cyst

Androsterone Long Chain Fatty Acid Esters in Human Breast Cyst Fluid*

1985 ◽  
Vol 60 (5) ◽  
pp. 940-946 ◽  
Author(s):  
UMA RAJU ◽  
MORTIMER LEVITZ ◽  
SILA BANERJEE ◽  
ALADAR BENCSATH ◽  
FRANK H. FIELD
Keyword(s):  
Fatty Acid ◽  
Chain Fatty Acid ◽  
Cyst Fluid ◽  
Fatty Acid Esters ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Long Chain Fatty Acid ◽  
Breast Cyst ◽  
Acid Esters ◽  
Long Chain
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