IK : A novel cell mitosis regulator that contributes to carcinogenesis

Blood films from early sixth instar larvae of Euxoa declarata (Lepidoptera: Noctuidae) stained in hematoxylin – eosin – alcian blue showed unequivocal examples of mitosis in spherule cells. The improved visibility of mitosis and the estimation of the mitotic index from counts of dividing cells per 1000 cells of each type indicated a far greater potential maximum production of spherule cells and granular haemocytes by mitosis than reported previously. Certain other methods of staining showed similar clear examples of spherule cell mitosis.

CSE1L participates in regulating cell mitosis in human seminoma

Cell Proliferation ◽

10.1111/cpr.12549 ◽

2018 ◽

Vol 52 (2) ◽

pp. e12549 ◽

Cited By ~ 1

Author(s):

Chunyan Liu ◽

Jiajing Wei ◽

Kang Xu ◽

Xiaosong Sun ◽

Huiping Zhang ◽

...

Keyword(s):

Cell Mitosis

The cell cycle of symbiotic Chlorella. I. The relationship between host feeding and algal cell growth and division

Journal of Cell Science ◽

10.1242/jcs.77.1.225 ◽

1985 ◽

Vol 77 (1) ◽

pp. 225-239

Author(s):

P.J. McAuley

Keyword(s):

Cell Division ◽

Cell Growth ◽

Host Cell ◽

Algal Cell ◽

Host Cells ◽

Digestive Cell ◽

Host Feeding ◽

Digestive Cells ◽

Division Factor ◽

Cell Mitosis

When green hydra were starved, cell division of the symbiotic algae within their digestive cells was inhibited, but algal cell growth, measured as increase in either mean volume or protein content per cell, was not. Therefore, control of algal division by the host digestive cells must be effected by direct inhibition of algal mitosis rather than by controlling algal cell growth. The number of algae per digestive cell increased slightly during starvation, eventually reaching a new stable level. A number of experiments demonstrated that although there was a relationship between host cell and algal mitosis, this was not causal: the apparent entrainment of algal mitosis to that of the host cells could be disrupted. Thus, there was a delay in algal but not host cell mitosis when hydra were fed after prolonged starvation, and algae repopulated starved hydra with lower than normal numbers of algae (reinfected aposymbionts or hydra transferred to light after growth in continuous darkness). Two experiments demonstrated a direct stimulation of algal cell division by host feeding. Relationships of algal and host cell mitosis to numbers of Artemia digested per hydra were different, and in hydra fed extracted Artemia algal, but not host cell, mitosis was reduced in comparison to that in control hydra fed live shrimp. It is proposed that algal division may be dependent on a division factor, derived from host digestion of prey, whose supply is controlled by the host cells. Numbers of algae per cell would be regulated by competition for division factor, except at host cell mitosis, when the algae may have temporarily uncontrolled access to host pools of division factor. The identity of the division factor is not known, but presumably is a metabolite needed by both host cells and algae.

SGK phosphorylates Cdc25 and Myt1 to trigger cyclin B–Cdk1 activation at the meiotic G2/M transition

The Journal of Cell Biology ◽

10.1083/jcb.201812122 ◽

2019 ◽

Vol 218 (11) ◽

pp. 3597-3611 ◽

Cited By ~ 7

Author(s):

Daisaku Hiraoka ◽

Enako Hosoda ◽

Kazuyoshi Chiba ◽

Takeo Kishimoto

Keyword(s):

Somatic Cell ◽

Cyclin A ◽

Pi3k Pathway ◽

Cyclin B ◽

Hormonal Stimulation ◽

Oocyte Meiosis ◽

M Phase ◽

Mitosis And Meiosis ◽

Cell Mitosis ◽

Stimulation Of

The kinase cyclin B–Cdk1 complex is a master regulator of M-phase in both mitosis and meiosis. At the G2/M transition, cyclin B–Cdk1 activation is initiated by a trigger that reverses the balance of activities between Cdc25 and Wee1/Myt1 and is further accelerated by autoregulatory loops. In somatic cell mitosis, this trigger was recently proposed to be the cyclin A–Cdk1/Plk1 axis. However, in the oocyte meiotic G2/M transition, in which hormonal stimuli induce cyclin B–Cdk1 activation, cyclin A–Cdk1 is nonessential and hence the trigger remains elusive. Here, we show that SGK directly phosphorylates Cdc25 and Myt1 to trigger cyclin B–Cdk1 activation in starfish oocytes. Upon hormonal stimulation of the meiotic G2/M transition, SGK is activated by cooperation between the Gβγ-PI3K pathway and an unidentified pathway downstream of Gβγ, called the atypical Gβγ pathway. These findings identify the trigger in oocyte meiosis and provide insights into the role and activation of SGK.

Cell mitosis event analysis in phase contrast microscopy images using deep learning

Medical Image Analysis ◽

10.1016/j.media.2019.06.011 ◽

2019 ◽

Vol 57 ◽

pp. 32-43 ◽

Cited By ~ 1

Author(s):

Yunxiang Mao ◽

Liang Han ◽

Zhaozheng Yin

Keyword(s):

Deep Learning ◽

Phase Contrast ◽

Phase Contrast Microscopy ◽

Event Analysis ◽

Contrast Microscopy ◽

Cell Mitosis ◽

Microscopy Images

Microwave Irradiation and the Circadian Rhythm of Bone Marrow Cell Mitosis*

Journal of Microwave Power ◽

10.1080/00222739.1974.11688898 ◽

1974 ◽

Vol 9 (1) ◽

pp. 31-37 ◽

Cited By ~ 9

Author(s):

P. Czerski ◽

Ewa Paprocka-Słonka ◽

Anna Stolarska

Keyword(s):

Bone Marrow ◽

Circadian Rhythm ◽

Microwave Irradiation ◽

Bone Marrow Cell ◽

Marrow Cell ◽

Cell Mitosis

Dephosphorylation of Barrier-to-autointegration Factor by Protein Phosphatase 4 and Its Role in Cell Mitosis

Journal of Biological Chemistry ◽

10.1074/jbc.m113.492777 ◽

2013 ◽

Vol 289 (2) ◽

pp. 1119-1127 ◽

Cited By ~ 31

Author(s):

Xiaolei Zhuang ◽

Elena Semenova ◽

Dragan Maric ◽

Robert Craigie

Keyword(s):

Protein Phosphatase ◽

Cell Mitosis

Abstract 2919: Unexpected role of CRAF in tumor cell mitosis revealed by an allosteric inhibitor

10.1158/1538-7445.am2011-2919 ◽

2011 ◽

Author(s):

Ainhoa Mielgo ◽

Eric Murphy ◽

Miller Huang ◽

Laetitia Seguin ◽

Sara Weis ◽

...

Keyword(s):

Tumor Cell ◽

Allosteric Inhibitor ◽

Cell Mitosis

Genetic disorders and spermatogenesis

Reproduction Fertility and Development ◽

10.1071/r98029 ◽

1998 ◽

Vol 10 (1) ◽

pp. 97 ◽

Cited By ~ 34

Author(s):

R. I. McLachlan ◽

C. Mallidis ◽

K. Ma ◽

S. Bhasin ◽

D. M. de Kretser

Keyword(s):

Male Fertility ◽

Genetic Linkage ◽

Genetic Basis ◽

Genetic Disorders ◽

Genetic Regulation ◽

Testicular Development ◽

Paracrine Regulation ◽

Normal Spermatogenesis ◽

Cell Mitosis ◽

Spermatogenic Failure

Male infertility affects one man in twenty and a genetic basis seems likely in at least 30% of those men. Genetic regulation of fertility involves the inter-related processes of testicular development, spermatogenesis (involving germ cell mitosis, meiosis and spermatid maturation), and their endocrine and paracrine regulation. In regard to spermatogenesis, particular attention has been given to the Yq11 region, where some spermatogenesis genes (‘azoospermia factors’) appear to be located. Several candidate genes have been identified but have not been shown to have a defined or essential role in spermatogenesis. Microdeletions of Yq11 are found in ~15% of azoospermic or severely oligospermic men. The complexity of the genetic control of male fertility is demonstrated by the evidence for genes involved in spermatogenesis and sexual differentiation on the X chromosome and autosomes. Better understanding of the genetic regulation of normal spermatogenesis will provide new probes for clinical studies; however, at present the majority of spermatogenic failure remains without an identified genetic linkage. The advent of intracytoplasmic sperm injection permits fertility in many previously sterile men and presents the possibility of their transmission of infertility; appropriate counselling is required.