scholarly journals Severe antibody‐mediated transfusion‐related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non‐transfused male blood donor

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Charlotte Nielsen Agergaard ◽  
Thure Mors Haunstrup ◽  
Anne‐Louise Fjordside ◽  
John Baech ◽  
Rudi Steffensen ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Blood Donor ◽  
Fresh Frozen Plasma ◽  
Obstetric Patient ◽  
Fresh Frozen ◽  
Male Blood Donor ◽  
Frozen Plasma

scholarly journals Manajemen Perawatan Pada Pasien Dengan Transfussion Related Acute Lung Injury (TRALI) Di Ruang ICU

2020 ◽  
Vol 13 (2) ◽  
pp. 75-83
Author(s):  
Andi Nur Hidayah
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

Transfusi darah dilakukan pada pasien yang mengalami perdahan dengan berbagai penyebab patologis yang mendasari atau terjadinya trauma yang mengakibatkan jumlah sel darah menurun. Transfusi disini termasuk semua jenis produk darah, sel darah merah (PRBC), Fresh Frozen Plasma (FFP), platelet (PLT). Transfusion Related Acute Lung Injury (TRALI) merupakan sindrom fatal yang menyebabkan gangguan pernafasan akut, ini adalah salah satu efek samping transfusi darah yang dapat menyebabkan morbiditas dan mortalitas di ICU. TRALI dapat muncul 6 jam pertama setelah transfusi atau hingga 72 jam selanjutnya. Disini kami membahas tentang 5 laporan kasus TRALI yang terjadi di ICU dengan penanganan suportif yang berfokus pada dukungan pernafasan dengan bantuan oksigen maupun ventilasi mekanik.

Transfusion-related acute lung injury (TRALI) after fresh frozen plasma in a patient with coagulopathy

1996 ◽  
Vol 40 (5) ◽  
pp. 641-644 ◽  
Author(s):  
L. Lindgren ◽  
A. Yli-Hankala ◽  
L. Halme ◽  
S. Koskimies ◽  
R. Orko
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals A Case Report of Transfusion-Related Acute Lung Injury Induced in the Patient with HLA Antibody after Fresh Frozen Plasma Transfusion

2015 ◽  
Vol 26 (3) ◽  
pp. 309-315 ◽  
Author(s):  
Ki Sul Chang ◽  
Dae Won Jun ◽  
Youngil Kim ◽  
Hyunwoo Oh ◽  
Min Koo Kang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Case Report ◽  
Lung Injury ◽  
Fresh Frozen Plasma ◽  
Plasma Transfusion ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Hla Antibody

scholarly journals A prophylactic fresh frozen plasma transfusion leads to a possible case of transfusion-related acute lung injury

2014 ◽  
Vol 2014 (jul21 1) ◽  
pp. bcr2014204101-bcr2014204101 ◽  
Author(s):  
D. Banerjee ◽  
R. Hussain ◽  
J. Mazer ◽  
G. Carino
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Fresh Frozen Plasma ◽  
Plasma Transfusion ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals Transfusion related acute lung injury: a case report

2018 ◽  
Vol 7 (1) ◽  
pp. 285
Author(s):  
Javier Alcazar Castro ◽  
Alejandro Zárate Aspiros ◽  
Elias N. Andrade Cuellar ◽  
Brenda M. Álvarez Pérez ◽  
Alan Isaac Valderrama Treviño ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hypovolemic Shock ◽  
Fresh Frozen Plasma ◽  
Blood Products ◽  
Hemodynamic Overload ◽  
Fresh Frozen ◽  
Crystalloid Solutions ◽  
Frozen Plasma ◽  
Complications Of Blood Transfusion

Transfusion Related Acute Lung Injury (TRALI) is one of the most serious complications of blood transfusion. All blood components have been implicated and most often those that contain plasma. The diagnosis is based fundamentally on the integration of clinical, radiological and gasometry elements, once the rest of the possible causes of acute lung injury have been ruled out. The differential diagnosis of a patient who develops a sudden pattern of respiratory failure after a transfusion of blood products must include hemodynamic overload, anaphylactic reaction, bacterial contamination of transfused blood products, haemolytic transfusion reaction and TRALI. Author presented the clinical case of a 33-year-old female patient with grade III hypovolemic shock due to a ruptured ectopic pregnancy, reanimated with crystalloid solutions, globular packages and fresh frozen plasma. The patient developed TRALI for what was managed with ventilatory and hemodynamic support in ICU.

scholarly journals Manajemen Perioperatif pada Perdarahan akibat Atonia Uteri

2020 ◽  
Vol 3 (1) ◽  
pp. 47-58
Author(s):  
Budi Yulianto Sarim
Keyword(s):  
Acute Lung Injury ◽  
Blood Transfusion ◽  
Lung Injury ◽  
Post Partum ◽  
Fresh Frozen Plasma ◽  
Uterine Atony ◽  
Factor Vii ◽  
First Choice ◽  
Fresh Frozen ◽  
Frozen Plasma

Perdarahan obstetri merupakan penyebab utama kematian maternal dan perinatal. Atonia uteri merupakan penyebab tersering perdarahan postpartum. Perdarahan post partum adalah perdarahan lebih dari 500 cc setelah bayi lahir pervaginam atau lebih dari 1.000 ml setelah persalinan abdominal atau jumlah perdarahan lebih dari normal dan telah menyebabkan perubahan tanda vital. Penyebab atonia uteri adalah overdistensi uterus, kelelahan otot miometrium, plasenta letak rendah, toksin bakteri (korioamnionitis, endomiometritis, septikemia), hipoksia akibat hipoperfusi atau uterus couvelaire pada solusio plasenta dan hipotermia akibat resusitasi masif. Manajemen atonia uteri dapat berupa non farmakologi, farmakologi dan pembedahan menurut algoritma Varatharajan yaitu “HAEMOSTASIS”.Manejemen perioperatif atoni uteri terdiri dari terapi O2, monitoring noninvasif, pemasangan jalur intra vena dengan menggunakan kateter intravena yang besar dan resusitasi cairan. Tehnik anestesi tergantung keadaan klinis dan rencana tindakan berikutnya oleh dokter kandungan. Pilihan pertama transfusi darah adalah transfusi sel darah merah, platelet, fresh frozen plasma, kriopresipitat, faktor VII dan fibrinogen sintetis (RiaSTAP), Transfusi masif adalah pemberian transfusi darah sebanyak volume darah pasien dalam waktu 24 jam atau lebih dari 7 % berat badan ideal dewasa. Komplikasi yang dapat terjadi pada transfusi masif adalah hipotermi, hipokalsemia, hipomagnesemia, hiperkalemia, asidosis/ alkalosis, koagulopati dilusional, transfusion related acute lung injury (TRALI) Perioperative Management in Bleeding cause by Uterine Atony Abstract Obstetric bleeding is a major cause of maternal and perinatal death. Uterine atony is the most common cause of postpartum hemorrhage. Post partum hemorrhage is bleeding more than 500 cc after the baby is vaginal labor or more than 1,000 ml after abdominal labor or the amount of bleeding is more than normal and has caused changes in vital signs. The causes of uterine atony are uterine overdistence, myometrial muscle fatigue, low lying placenta, bacterial toxin (chorioamnionitis, endomyometritis, septicemia), hypoxia due to hypoperfusion or uterine couvelaire in placental abruption and hypothermia due to massive resuscitation. Management of uterine atony can be in the form of non pharmacology, pharmacology and surgery according to the Varatharajan algorithm is "HAEMOSTASIS". Anesthesia management consists of O2 therapy, noninvasive monitoring, installation of intravenous lines using a large intravenous catheter and fluid resuscitation. Anesthesia techniques depend on clinical conditions and subsequent action plans by the obstetrician. The first choice of blood transfusion is transfusion of red blood cells, platelets, fresh frozen plasma, cryoprecipitate, factor VII and synthetic fibrinogen (RiaSTAP), massive transfusion is the administration of blood transfusion as much as the patient's blood volume within 24 hours or more than 7% of the ideal adult body weight . Complications that can occur in massive transfusions are hypothermia, hypocalcemia, hypomagnesemia, hyperkalemia, acidosis / alkalosis, dilutional coagulopathy, transfusion related acute lung injury (TRALI).

scholarly journals Severe Transfusion-related Acute Lung Injury in the Intensive Care Unit Secondary to Transfusion of Fresh Frozen Plasma

2005 ◽  
Vol 33 (3) ◽  
pp. 400-402 ◽  
Author(s):  
G. R. Rajan
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Fresh Frozen Plasma ◽  
Appropriate Treatment ◽  
Fresh Frozen ◽  
Life Threatening ◽  
Proper Diagnosis ◽  
Frozen Plasma

Transfusion-related acute lung injury (TRALI) is a life-threatening complication of transfusion of blood products. A case of severe TRALI secondary to infusion of fresh frozen plasma in the intensive care unit is discussed. Additionally, the aetiology and pathogenesis of this relatively under-diagnosed and under-reported clinical entity is reviewed. It is our conclusion that proper diagnosis and reporting is necessary for prompt and appropriate treatment of the patient and to prevent additional reactions in other patients.

Male-only fresh-frozen plasma for transfusion-related acute lung injury prevention: before-and-after comparative cohort study

Transfusion ◽  
2010 ◽  
Vol 51 (6) ◽  
pp. 1278-1283 ◽  
Author(s):  
Johanna C. Wiersum-Osselton ◽  
Rutger A. Middelburg ◽  
Erik A.M. Beckers ◽  
Anita J.W. van Tilborgh ◽  
Pauline Y. Zijlker-Jansen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Injury Prevention ◽  
Fresh Frozen Plasma ◽  
Before And After ◽  
Fresh Frozen ◽  
Comparative Cohort Study ◽  
Frozen Plasma
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