Nail changes in systemic amyloidosis

A 60-year-old woman with a 13-year history of monoclonal gammopathy of unknown significance (MGUS) presented with worsening nail dystrophy. Prior workup for systemic amyloidosis had been unrevealing, and no other signs of cutaneous disease were present. Nail biopsy was consistent with amyloid deposition, and the patient subsequently underwent autologous hematopoietic stem cell transplantation for AL amyloidosis. In light of the growing literature regarding nail changes as a presenting sign of systemic amyloidosis and the promising utility of nail biopsy, we suggest a low threshold for biopsy in appropriate patients when nail changes characteristic of amyloidosis are refractory to conventional treatment.

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Nail Changes as the First Sign of Systemic Amyloidosis

Dermatology ◽

10.1159/000247630 ◽

1991 ◽

Vol 183 (1) ◽

pp. 44-46 ◽

Cited By ~ 21

Author(s):

P.A. Fanti ◽

A. Tosti ◽

R. Morelli ◽

G. Galbiati

Keyword(s):

Systemic Amyloidosis ◽

Nail Changes

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Nail changes as the only skin abnormality in myeloma-associated systemic amyloidosis

British Journal of Dermatology ◽

10.1111/j.1365-2133.1997.tb03764.x ◽

1997 ◽

Vol 137 (3) ◽

pp. 471-472 ◽

Cited By ~ 21

Author(s):

G. Mancuso ◽

P.A. Fanti ◽

R.M. Berdondini

Keyword(s):

Systemic Amyloidosis ◽

Nail Changes

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Experimental Amyloidosis Induced by Immune Complex

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066978 ◽

1971 ◽

Vol 29 ◽

pp. 582-583

Author(s):

A. Kawaoi

Keyword(s):

Immune Complex ◽

Systemic Amyloidosis ◽

Human Diseases ◽

Experimental Amyloidosis ◽

Freund’S Complete Adjuvant ◽

Freund's Complete Adjuvant ◽

Immunological Approach ◽

Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

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