<div>
<div>
<div>
<p>There are relatively few methods that accom-
plish the selective alkoxylation of sp3-hybridized C–H bonds,
particularly in comparison to the numerous analogous strate-
gies for C–N and C–C bond formation. We report a photo-
catalytic protocol for the functionalization of benzylic C–H
bonds with a wide range of readily available oxygen nucleo-
philes. Our strategy merges the photoredox activation of
arenes with copper(II)-mediated oxidation of the resulting
benzylic radicals, which enables the introduction of benzylic
C–O bonds with high site selectivity, chemoselectivity, and
functional group tolerance. This method enables the late-
stage introduction of complex alkoxy groups into bioactive
molecules, providing a practical new tool with potential appli-
cations in synthesis and medicinal chemistry.
</p>
</div>
</div>
</div>