Classic Paper but No New Data

ChemViews ◽  
2013 ◽  
Author(s):  
Richard Threlfall
Keyword(s):  
Classic Paper

X-Ray Analysis of Frozen Hydrated Sections:The Unconventional Approach

1982 ◽  
Vol 40 ◽  
pp. 754-757
Author(s):  
R. Beeuwkes ◽  
A. Saubermann ◽  
P. Echlin ◽  
S. Churchill
Keyword(s):  
Ratio Method ◽  
Frozen Sections ◽  
Technical Problems ◽  
Sample Handling ◽  
X Ray ◽  
Common Group ◽  
Ideal Method ◽  
Classic Paper ◽  
Physical Principles ◽  
The Ideal

Fifteen years ago, Hall described clearly the advantages of the thin section approach to biological x-ray microanalysis, and described clearly the ratio method for quantitive analysis in such preparations. In this now classic paper, he also made it clear that the ideal method of sample preparation would involve only freezing and sectioning at low temperature. Subsequently, Hall and his coworkers, as well as others, have applied themselves to the task of direct x-ray microanalysis of frozen sections. To achieve this goal, different methodological approachs have been developed as different groups sought solutions to a common group of technical problems. This report describes some of these problems and indicates the specific approaches and procedures developed by our group in order to overcome them. We acknowledge that the techniques evolved by our group are quite different from earlier approaches to cryomicrotomy and sample handling, hence the title of our paper. However, such departures from tradition have been based upon our attempt to apply basic physical principles to the processes involved. We feel we have demonstrated that such a break with tradition has valuable consequences.

Upper and Lower Palaeolithic Man in East Yorkshire

1930 ◽  
Vol 6 (3) ◽  
pp. 226-233 ◽  
Author(s):  
J. P. T. Burchell
Keyword(s):  
Complete Section ◽  
Boulder Clay ◽  
Sand And Gravel ◽  
Classic Paper ◽  
Lower Palaeolithic

The most complete section of the glacial series of deposits described and illustrated in Lamplugh's classic paper entitled “On the drifts of Flamborough Head” is that which is located at Danes' Dyke.Referring to this section Lamplugh says:—“I have spent much time in exploring this section, and consider that the beds up to this horizon represent the Basement Clay, while the persistent upper band of brown Boulder-clay (3) is all that remains of the upper Clay of Sewerby, this bed and the underlying sand and gravel (3b) together taking the place of the Purple Clays of Bridlington and Holderness. Above this clay lie the Sewerby Gravels (2b), the lower part chalkless and the upper layers composed chiefly of chalk-pebbles, as noticed farther west. A few feet of loamy stuff overlies these gravels at the cliff top (2c), resembling a weathered Boulder-clay, and a little farther east (near Hartindale Gutter) a seam of Boulder-clay certainly appears in these gravels, their contemporaneity with the uppermost part of the Boulder-clay, and consequently their Glacial age, being thus fully established.”

Benign Chronic Diarrhea of Infancy

1981 ◽  
Vol 3 (5) ◽  
pp. 153-158
Author(s):  
W. Allan Walker
Keyword(s):  
Irritable Bowel Syndrome ◽  
Chronic Diarrhea ◽  
Spontaneous Resolution ◽  
Gastrointestinal Problems ◽  
High Incidence ◽  
Bowel Movements ◽  
Separate Clinical Entity ◽  
Irritable Bowel ◽  
Classic Paper ◽  
Referral Practice

Chronic nonspecific diarrhea of infancy (CNSD) or irritable bowel syndrome represents one of the most common gastrointestinal problems confronted by practicing pediatricias. In the subspecialty setting of the pediatric gastroenterologist, this entity comprised almost 35% of the outpatient referral practice. CNSD, originally thought to be part of the celiac syndrome, was described as a separate clinical entity by Cohlan in 1956.1 Since that time in the classic paper on this subject, Davidson and Wasserman2 have described consistent diagnostic criteria further characterizing CNSD as a recognizable syndrome. The onset of symptoms occurs classically between 6 and 30 months of age with the development of three to six loose stools with mucous per day, with no associated malabsorption or growth and development abnormalities (to be discussed in detail below). Whereas spontaneous resolution of CNSD is anticipated by 39 months of age, longitudinal observations indicate that these patients have a high incidence of functional bowel complaints during adolescence and beyond suggesting a continuum with "irritable bowel syndrome" of adulthood.3 From the standpoint of the child, this "complaint" all too frequently becomes the "problem" when the frequency and/or consistency of the bowel movements impair training or become intolerable to the parents.

The Validation of Measures of Outcome Following Suture of Divided Peripheral Nerves Supplying the Hand

1990 ◽  
Vol 15 (1) ◽  
pp. 25-34
Author(s):  
D. MARSH
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Sensory Function ◽  
The Other ◽  
Functional Tests ◽  
Nerve Suture ◽  
Classic Paper

Erik Moberg pioneered the idea of validating measures of sensory function following peripheral nerve suture by correlating their results with those of functional tests. However it is important that powerful prior variables (age at suture, time elapsed since suture and delay between injury and suture) be controlled. Failure to do this may result in spurious correlations, as illustrated by analysis of two sets of data, one collected by the author and the other given in the classic paper of Önne (1962).

Discovering the mechanism of capacitative calcium entry

2006 ◽  
Vol 291 (6) ◽  
pp. C1104-C1106 ◽  
Author(s):  
Juan A. Rosado
Keyword(s):  
Acinar Cells ◽  
Calcium Entry ◽  
Capacitative Calcium Entry ◽  
Historical Significance ◽  
Intracellular Ca ◽  
Lacrimal Acinar Cells ◽  
Classic Paper

This essay examines the historical significance of an APS classic paper that is freely available online: Kwan CY, Takemura H, Obie JF, Thastrup O, and Putney JW Jr. Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells. Am J Physiol Cell Physiol 258: C1006–C1015, 1990. ( http://ajpcell.physiology.org/cgi/reprint/258/6/C1006 )

Comroe's study of aortic chemoreceptors: a path well chosen

2004 ◽  
Vol 97 (5) ◽  
pp. 1595-1596 ◽  
Author(s):  
Judith A. Neubauer
Keyword(s):  
Historical Significance ◽  
And Function ◽  
Classic Paper

This essay looks at the historical significance of an APS classic paper that is freely available online Comroe JH Jr. The location and function of the chemoreceptors of the aorta. Am J Physiol 127: 176—191, 1939 ( http://ajplegacy.physiology.org/cgi/reprint/127/1/176 ).

Windmill Hill—East or West?

1956 ◽  
Vol 21 ◽  
pp. 96-101
Author(s):  
Stuart Piggott
Keyword(s):  
Present Writer ◽  
The Family ◽  
European Neolithic ◽  
Neolithic Cultures ◽  
Classic Paper

Twenty-five years ago Professor Gordon Childe laid the foundations of our knowledge of the foreign affinities of our British Neolithic cultures in a classic paper. In it he gave expression to the view which we have all of us held since that time, that ‘the culture associated with Windmill Hill pottery belongs, like the pottery itself, to a Western family’; ‘Western’ being used in the sense defined by Schuchhardt in his division of the European Neolithic groups. Our knowledge of the complexities of the Windmill Hill culture increased with new discoveries, and we were also able to grasp something of the diversity of the cultures within the Western family at large, particularly as a result of the work of Vouga, Vogt and von Gonzenbach in Switzerland. But the place of the Windmill Hill culture within the family seemed unchallenged, and the present writer re-affirmed a couple of years ago that it seemed to him ‘abundantly clear that the Windmill Hill culture is a member of the great Western family’. It is the purpose of this paper to re-examine the question in the light of certain new orientations in Continental prehistory which make it desirable to ask whether the culture of Windmill Hill can be regarded as an indivisible unit, or whether it may not contain contributions from more than one European source.

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