ChemInform Abstract: PHOSPHORUS-CONTAINING MONOAZO DYES BASED ON N-ARYLAMINOALKYL ORGANOPHOSPHORUS COMPOUNDS

1976 ◽  
Vol 7 (26) ◽  
pp. no-no
Author(s):  
K. A. PETROV ◽  
V. A. CHAUZOV ◽  
T. S. EROKHINA ◽  
L. P. CHERNOBROVKINA
Keyword(s):  
Organophosphorus Compounds ◽  
Phosphorus Containing ◽  
Monoazo Dyes

Organophosphorus Compounds. I. 2-Chloroalkylphosphonic Acids as Phosphorylating Agents

1963 ◽  
Vol 16 (4) ◽  
pp. 596 ◽  
Author(s):  
JA Maynard ◽  
JM Swan
Keyword(s):  
Magnetic Resonance ◽  
Proton Magnetic Resonance ◽  
Organophosphorus Compounds ◽  
Chloride Ion ◽  
The Other ◽  
High Yield ◽  
Neutral Solution ◽  
Phosphate Ion ◽  
Phosphorus Containing ◽  
Group 2

Alcohols and phenols are phosphorylated in high yield by reaction with various 2-chloroalkylphosphonic acids at 20-50�C in the presence of three or more molar equivalents of cyclohexylamine or triethylamine, the other products being the corresponding alk-1-ene and chloride ion. The reaction probably proceeds by attack of an ROH molecule on the phosphorus atom of a doubly-ionized phosphonate group. 2-Chlorodecyl-, 10-carboxy-2-chlorodecyl-, and 2-chloro-octylphosphonic acid decompose rapidly in neutral solution giving chloride ion, phosphate ion, and the corresponding alk-1-ene. In the absence of hydroxylic compounds, 2-chlorodecylphosphonic acid is decomposed by cyclohexylamine to dec-1-ene and a product which appears to be N-cyclohexylphosphoramidate; t-amines and also aniline cause dehydrohalogenation to dec-1-enylphosphonic acid. The proton magnetic resonance spectra of most of the phosphorus-containing substances described herein are recorded.

scholarly journals Acetylcholinesterase. Two types of inhibition by an organophosphorus compound: one the formation of phosphorylated enzyme and the other analogous to inhibition by substrate

1969 ◽  
Vol 115 (2) ◽  
pp. 147-162 ◽  
Author(s):  
W. N. Aldridge ◽  
Elsa Reiner
Keyword(s):  
Binding Sites ◽  
Dissociation Constants ◽  
Organophosphorus Compounds ◽  
Active Centre ◽  
Phosphorus Containing ◽  
High Concentrations ◽  
Influence Of Substrate ◽  
A Site ◽  
Kinetics Of ◽  
Related Compounds

1. The kinetics of the reaction of di-(2-chloroethyl) 3-chloro-4-methylcoumarin-7-yl phosphate (haloxon) and related compounds with acetylcholinesterase were studied and found to be unusual. 2. By a progressive reaction haloxon produces a di-(2-chloroethyl)phosphorylated enzyme. The influence of substrate on this reaction leading to a phosphorylated active centre was studied. From competition experiments between inhibitor and substrate values of Km for acetylcholine and acetylthiocholine of 0·79mm and 0·23mm respectively were derived. 3. Haloxon also combines with acetylcholinesterase by a non-progressive reaction, producing a complex that is reversible by dilution and by high concentrations of acetylcholine and acetylthiocholine. From this non-progressive reaction the competition between haloxon and substrate was studied, and it was shown that haloxon combines with a site involved in inhibition by substrate. From competition experiments the following dissociation constants were derived: for combination of haloxon and this site Ki is 4·9μm and for the combination of substrates with this site K88 values are 12mm and 3·3mm for acetylcholine and acetylthiocholine respectively. 4. The non-phosphorus-containing compound 3-chloro-7-hydroxy-4-methylcoumarin was shown to be a good reagent for the site involved in inhibition by substrate; its dissociation constant for the combination with this site is 30μm. 5. In order to interpret the experimental results, theoretical equations were derived for an enzyme with two binding sites to both of which substrate and inhibitor can combine. The equations correlate the activity of the enzyme with the concentration of substrate and inhibitor, for both progressive and non-progressive inhibition. These equations are applicable to reactions of acetylcholinesterase with organophosphorus compounds, carbamates etc. and may be applicable to other enzymes possessing two binding sites.

A Review of Phosphorus- Containing Flame Retardants

1996 ◽  
Vol 14 (5) ◽  
pp. 353-366 ◽  
Author(s):  
Joseph Green
Keyword(s):  
Chemical Structure ◽  
Flame Retardants ◽  
Western Europe ◽  
Organophosphorus Compounds ◽  
Red Phosphorus ◽  
Phosphorus Containing ◽  
Trade Names ◽  
Inorganic Phosphates

Phosphorus-containing flame retardants include red phosphorus, inorganic phosphates, organophosphorus compounds and chlorophosphorus compounds. These are reviewed showing chemical structure and major applica tions. U.S., Western Europe and Japanese producers are given along with their trade names. Intumescent phosphorus systems and compounds are discussed.

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