ChemInform Abstract: THE ROLE OF TITANIUM AND IRON COMPLEXES IN THE DEOXYGENATION OF AROMATIC NITROSO-COMPOUNDS

There are two possibilities how to follow equilibria of organic compounds established in aqueous solutions using polarography: for very fast reactions, information can be obtained from shifts of half-wave potentials. For slowly established equilibria, the changes in the limiting current are followed. In both cases variation of the half-wave potentials or limiting currents with concentration of a reactant, present in excess, is followed. The types of reactions, which had been followed in this way, are as follows: hydration–dehydration equilibria, additions of hydroxide ion to carbonyl and nitroso compounds, the role of slowly established acid–base equilibria involving C-acids; further also reactions involving the addition of ammonia, primary amines, hydroxylamine, and hydrazine to carbonyl compounds.

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Compounds Related to Acridine. I. Condensation of Acridine Derivatives Having Active Methyl Group and Aromatic Nitroso Compounds

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.36.1477 ◽

1963 ◽

Vol 36 (11) ◽

pp. 1477-1485 ◽

Cited By ~ 31

Author(s):

Otohiko Tsuge ◽

Minoru Nishinohara ◽

Masashi Tashiro

Keyword(s):

Nitroso Compounds ◽

Methyl Group ◽

Acridine Derivatives ◽

Active Methyl ◽

Aromatic Nitroso Compounds

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Re: Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djh018 ◽

2004 ◽

Vol 96 (1) ◽

pp. 75-75 ◽

Cited By ~ 4

Author(s):

G. Capurso ◽

G. Delle Fave ◽

N. Lemoine

Keyword(s):

Pancreatic Cancer ◽

Gastric Acidity ◽

Nitroso Compounds

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Role of Bacterial Overgrowth in the Stomach as an Additional Risk Factor for Gastritis

Canadian Journal of Gastroenterology ◽

10.1155/2003/350347 ◽

2003 ◽

Vol 17 (suppl b) ◽

pp. 13B-17B ◽

Cited By ~ 15

Author(s):

Gregory Naylor ◽

Anthony Axon

Keyword(s):

Gastric Cancer ◽

Cell Mass ◽

Bacterial Overgrowth ◽

Nitroso Compounds ◽

Current Evidence ◽

Additional Risk Factor ◽

Proximal Small Bowel ◽

Increased Risk ◽

H Pylori

Gastric bacteria can either be ingested or ascend from the distal bowel; however, their survival is usually limited by gastric acidity and motility. A reduction in gastric acid can result in bacterial overgrowth in the stomach and proximal small bowel, and the number of organisms rises as the intragastric pH rises.The increased risk of noncardia gastric cancer seen in patients with hypochlorhydria may be explained by an excess of nitrites and N-nitroso compounds (NOCs). These compounds are found in the diet of populations with a high gastric cancer risk, but can also be produced by the organisms that exist in the hypochlorhydria stomach. It has long been hypothsized that nitrites and NOCs act as one of the triggers in the atrophy-metaplasia-dysplasia-carcinoma path. However, although indirect data have linked the premalignant changes of metaplasia and dysplasia to NOCs, direct measurement of gastric nitrites and NOCs has not confirmed such a link.The role ofHelicobacter pyloriin bacterial overgrowth is mainly as a cause of hypochlorhydria resulting from atrophic gastritis, leading to a reduction in the parietal cell mass.Acid-suppressing drugs can result in bacterial overgrowth and increased nitrites and NOCs, although there is no current evidence for an increased risk of gastric cancer in patients taking them. One explanation is that the stomach appears to be colonized by different organisms than those in patients with hypochlorhydria for other reasons. There is some evidence that bacterial overgrowth per se can cause gastric inflammation in mice; however, although in humans the degree of gastric inflammation is greater when overgrowth is more prominant this may simply reflect the greater degree of hypochlorhydria in patients with a more severe H pylori-induced inflammation.

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