ChemInform Abstract: Asymmetric Synthesis. Part 11. Stereoselective Synthesis of α-Alkyl-2-furfurylamines via d-Camphor Ketimine Intermediate.

ChemInform ◽  
2010 ◽  
Vol 22 (15) ◽  
pp. no-no
Author(s):  
Y. JIANG ◽  
J. DENG ◽  
W. HU ◽  
G. LIU ◽  
A. MI
Keyword(s):  
Asymmetric Synthesis ◽  
Stereoselective Synthesis

scholarly journals Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 401 ◽  
Author(s):  
Franz Steppeler ◽  
Dominika Iwan ◽  
Elżbieta Wojaczyńska ◽  
Jacek Wojaczyński
Keyword(s):  
Hydrogen Bond ◽  
Drug Development ◽  
Asymmetric Synthesis ◽  
Stereoselective Synthesis ◽  
Strong Hydrogen Bond ◽  
Hydrogen Bond Donor ◽  
Drug Candidates ◽  
Current State ◽  
The Family ◽  
Donor Capability

For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ureas and offer, appropriately modified, great potential as organocatalysts, chelators, drug candidates, etc. The review focuses on the family of chiral thioureas, presenting an overview of the current state of knowledge on their synthesis and selected applications in stereoselective synthesis and drug development.

A Highly Stereoselective Synthesis of Glycidic Amides Based on a New Class of Chiral Sulfonium Salts: Applications in Asymmetric Synthesis

2012 ◽  
Vol 18 (47) ◽  
pp. 15190-15201 ◽  
Author(s):  
Francisco Sarabia ◽  
Carlos Vivar-García ◽  
Miguel García-Castro ◽  
Cristina García-Ruiz ◽  
Francisca Martín-Gálvez ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Stereoselective Synthesis ◽  
Sulfonium Salts ◽  
New Class

ChemInform Abstract: A Highly Stereoselective Synthesis of Glycidic Amides Based on a New Class of Chiral Sulfonium Salts: Applications in Asymmetric Synthesis.

ChemInform ◽  
2013 ◽  
Vol 44 (16) ◽  
pp. no-no
Author(s):  
Francisco Sarabia ◽  
Carlos Vivar-Garcia ◽  
Miguel Garcia-Castro ◽  
Cristina Garcia-Ruiz ◽  
Francisca Martin-Galvez ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Stereoselective Synthesis ◽  
Sulfonium Salts ◽  
New Class

scholarly journals Step economy in the Stereoselective Synthesis of Functionalized Oxindoles via Organocatalytic Domino/One-pot Reactions

2021 ◽  
Vol 25 ◽  
Author(s):  
Martina Bortolami ◽  
Francesca Leonelli ◽  
Marta Feroci ◽  
Fabrizio Vetica
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Bioactive Compounds ◽  
Stereoselective Synthesis ◽  
Environmentally Friendly ◽  
Important Class ◽  
One Pot ◽  
Asymmetric Organocatalysis ◽  
Toxic Approach

: Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.

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