ChemInform Abstract: Nothramicin, a New Anthracycline Antibiotic from Nocardia sp. MJ896-43F17.

ChemInform ◽  
2010 ◽  
Vol 29 (27) ◽  
pp. no-no
Author(s):  
I. MOMOSE ◽  
N. KINOSHITA ◽  
R. SAWA ◽  
H. NAGANAWA ◽  
H. IINUMA ◽  
...  
Keyword(s):  
Anthracycline Antibiotic ◽  
Nocardia Sp

scholarly journals Nothramicin, a New Anthracycline Antibiotic from Nocardia sp. MJ896-43F17.

1998 ◽  
Vol 51 (2) ◽  
pp. 130-135 ◽  
Author(s):  
ISAO MOMOSE ◽  
NAOKO KINOSHITA ◽  
RYUICHI SAWA ◽  
HIROSHI NAGANAWA ◽  
HIRONOBU IINUMA ◽  
...  
Keyword(s):  
Anthracycline Antibiotic ◽  
Nocardia Sp

Microscopic investigations of novel intracellular bodies of a Nocardia SP

1994 ◽  
Vol 52 ◽  
pp. 356-357
Author(s):  
J. L. Stites
Keyword(s):  
Uranyl Acetate ◽  
Electron Microscopic ◽  
En Bloc ◽  
Ribonucleic Acids ◽  
Transmission Electron ◽  
Nocardia Sp ◽  
Internal Constitution ◽  
Membrane Bound ◽  
Molecular Components ◽  
Protein Rich

A Nocardia sp.was found during an initial transmission electron microscopic (TEM) examination to have unusual intracellular bodies (ICB's) which do not appear to have been described previously in the literature. Most intracellular structures within bacteria have been classified as storage granules, a product of membrane invagination (i.e. mesosomes), or vacuoles. In bacteria there are no known intracellular membrane-bound organelles, and all internal membranes are invaginations of the unit membrane. Several microscopic-level examinations of the Nocardia sp. ICB's were initiated in order to determine their overall structure, classification, and internal constitution.Different TEM staining procedures were performed to determine possible molecular components of the ICB. In all of the staining protocols the ICB's showed a lack of electron density similar to the cell wall. Because the ICB's showed no affinity to any stain, it appeared they do not have strong positive charge (phosphotungstic acid), are not protein rich (en bloc uranyl acetate), lack glycogen and are not phosphate or sulphur rich (lead citrate), nor do they contain lipids or ribonucleic acids (osmium tetroxide).

Cytotoxic activity of actinomycetes Nocardia sp. and Nocardiopsis sp. associated with marine sponge Amphimedon sp.

2021 ◽  
pp. 1-6
Author(s):  
Nourhan Hisham Shady ◽  
Ahmed F. Tawfike ◽  
Ramadan Yahia ◽  
Mostafa A. Fouad ◽  
Alexander O. Brachmann ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Marine Sponge ◽  
Nocardia Sp

scholarly journals Cororubicin, a new anthracycline antibiotic generating active oxygen in tumor cells.

1994 ◽  
Vol 47 (11) ◽  
pp. 1219-1225 ◽  
Author(s):  
KEN ISHIGAMI ◽  
YOICHI HAYAKAWA ◽  
HARUO SETO
Keyword(s):  
Tumor Cells ◽  
Active Oxygen ◽  
Anthracycline Antibiotic

Isolation of a chitinase overproducing mutant of Streptomyces peucetius defective in daunorubicin biosynthesis

2000 ◽  
Vol 46 (10) ◽  
pp. 956-960 ◽  
Author(s):  
Kuzhandhaivel S Vetrivel ◽  
Kuppamuthu Dharmalingam
Keyword(s):  
Biosynthetic Pathway ◽  
Time Course ◽  
Polyketide Synthase ◽  
Protein Profile ◽  
Restriction Enzymes ◽  
Wild Type ◽  
Anthracycline Antibiotic ◽  
Streptomyces Peucetius ◽  
Chitinase Production ◽  
Major Alteration

Streptomyces peucetius, producer of the antitumor anthracycline antibiotic daunorubicin, was mutagenized, and mutants defective in daunorubicin biosynthesis were screened. One mutant (SPVI), which failed to produce daunorubicin, was found to overproduce an extracellular chitinase. Time course analyses of chitinase production and of the extracellular protein profile showed that the increase in activity is due to increased synthesis of the enzyme protein. The production of chitinase in SPVI was repressed by glucose as in the case of wild-type S. peucetius. PFGE analysis of VspI restriction fragments of S. peucetius and SPVI showed that there was no major alteration in the mutant genome. The hybridization pattern of S. peucetius and SPVI genomic DNA digested with various restriction enzymes was identical when probed with dnrUVJI genes of the S. peucetius daunorubicin cluster and chiA of Streptomyces lividans 66. The possible step affected in the daunorubicin biosynthetic pathway could be a polyketide synthase, since aklanonic acid, the earliest detectable intermediate in the daunorubicin pathway, was not synthesized in SPVI.Key words: Streptomyces peucetius, chitinase, daunorubicin, NTG mutagenesis.

Hydroxyl radical generation by oligonucleotide derivatives of anthracycline antibiotic and synthetic quinone

1991 ◽  
Vol 77 (3) ◽  
pp. 325-339 ◽  
Author(s):  
Sergei I. Dikalov ◽  
Galina V. Rumyantseva ◽  
Lev M. Weiner ◽  
Dmitri S. Sergejev ◽  
Elena I. Frolova ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Anthracycline Antibiotic ◽  
Radical Generation ◽  
Derivatives Of ◽  
Oligonucleotide Derivatives

scholarly journals Abscesso cerebral por Nocardia sp em paciente imunossuprimido

2000 ◽  
Vol 33 (6) ◽  
pp. 609-612 ◽  
Author(s):  
Cristina Hueb Barata ◽  
Darci Alvarenga Gomes Oliveira ◽  
Arnaldo Lopes Colombo ◽  
Carlos Alberto Pires Pereira
Keyword(s):  
Nocardia Sp

Paciente portadora de anemia hemolítica autoimune e púrpura trombocitopênica idiopática (Síndrome de Evans) em uso de terapia imunossupressora (predinisona e azatioprina), desenvolveu quadro de abscesso cerebral não responsivo a 23 dias de terapia antimicrobiana. O diagnóstico de nocardiose foi possível após coleta de material de abscesso peribulbar e observação deste material por período superior há uma semana.

Dissection of the free energy of anthracycline antibiotic binding to DNA: electrostatic contributions

1993 ◽  
Vol 115 (13) ◽  
pp. 5360-5364 ◽  
Author(s):  
J. B. Chaires ◽  
W. Priebe ◽  
D. E. Graves ◽  
T. G. Burke
Keyword(s):  
Free Energy ◽  
Anthracycline Antibiotic
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