ChemInform Abstract: Cyclic Amide Derivatives as Potential Prodrugs. Synthesis and Evaluation of N-Hydroxymethylphthalimide Esters of Some Non-Steroidal Antiinflammatory Carboxylic Acid Drugs.

ChemInform ◽  
2010 ◽  
Vol 29 (29) ◽  
pp. no-no
Author(s):  
F. A. OMAR
Keyword(s):  
Carboxylic Acid ◽  
Amide Derivatives ◽  
Cyclic Amide

Synthesis and evaluation of a novel series of 6-bromo-1-cyclopentyl-1H-indazole-4-carboxylic acid-substituted amide derivatives as anticancer, antiangiogenic, and antioxidant agents

2019 ◽  
Vol 29 (1) ◽  
pp. 17-32
Author(s):  
Ajay S. Sawant ◽  
Sonali S. Kamble ◽  
Parshuram M. Pisal ◽  
Rohan J. Meshram ◽  
Sanjay S. Sawant ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Antioxidant Agents ◽  
Amide Derivatives

scholarly journals Synthesis of functional 2-substituted 1,3-dinitroimidazolidines. A new synthetic approach to high-energy compounds

2019 ◽  
Author(s):  
Sergey V Sysolyatin ◽  
Artyom E Paromov
Keyword(s):  
Carboxylic Acid ◽  
Ethyl Ester ◽  
Glyoxylic Acid ◽  
Acid Ethyl Ester ◽  
High Energy ◽  
Synthetic Approach ◽  
Synthetic Strategy ◽  
Hydrolysis Products ◽  
Amide Derivatives ◽  
Acid Catalyzed

Three new functional 2-substituted 1,3-dinitroImidazolidines  were synthesized herein. A synthetic strategy is suggested for structurally different α,α-dinitraminocarboxylic acids via condensation of glyoxylic acid ethyl ester with amine or amide derivatives. Alkali- and acid-catalyzed hydrolyses of ethyl 1,3-dinitro-1,3-diazacyclopentane-2-carboxylate were studied. A series of hydrolysis products were isolated. The Curtius rearrangement of 1,3-dinitroimidazolidine-2-carboxylic acid to 2-isocyanato-1,3-dinitroimidazolidine was carried out. Hydrolyses of 1,3-dinitroimidazolidine-2-carbonyl azide and 2-isocyanato-1,3-dinitroimidazolidine were studied. 1,3-Dinitroimidazolidine-2-amine was captured as 1,3-bis(1,3-dinitroimidazolidin-2-yl)urea.

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