ChemInform Abstract: 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT2A Receptor Antagonists.

10.1002/chin.200135124 ◽

2010 ◽

Vol 32 (35) ◽

pp. no-no

Author(s):

Michael Rowley ◽

et al. et al.

Keyword(s):

Receptor Antagonists ◽

High Affinity ◽

Orally Bioavailable

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Faculty Opinions recommendation of Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1080870.533803 ◽

2007 ◽

Author(s):

Thomas W von Geldern

Keyword(s):

Receptor Antagonists ◽

B1 Receptor ◽

Bradykinin B1 Receptor ◽

Orally Bioavailable

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The modulatory effects of high affinity GABA B receptor antagonists in an active avoidance learning paradigm in rats

Psychopharmacology ◽

10.1007/s002130050632 ◽

1998 ◽

Vol 137 (4) ◽

pp. 369-373 ◽

Author(s):

D. Getova ◽

N. G. Bowery

Keyword(s):

Avoidance Learning ◽

Active Avoidance ◽

Learning Paradigm ◽

Receptor Antagonists ◽

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Discovery of orally bioavailable NK1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00956-3 ◽

2003 ◽

Vol 13 (3) ◽

pp. 437-442 ◽

Author(s):

C. Genicot ◽

B. Christophe ◽

P. Collart ◽

M. Gillard ◽

L. Goossens ◽

...

Keyword(s):

Nk1 Receptor ◽

Receptor Antagonists ◽

Orally Bioavailable ◽

Nk1 Receptor Antagonists

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Pharmacological Characterization of Novel High Affinity CGRP Receptor Antagonists that are Selective for Human CGRP Receptors

The FASEB Journal ◽

10.1096/fasebj.20.4.a665-a ◽

2006 ◽

Vol 20 (4) ◽

Author(s):

Chrsitopher K. Taylor ◽

D. David Smith ◽

Peter W. Abel

Keyword(s):

Cgrp Receptor ◽

Receptor Antagonists ◽

Pharmacological Characterization ◽

High Affinity ◽

Cgrp Receptor Antagonists

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Novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridines. Potent angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(97)84011-1 ◽

1997 ◽

Vol 32 (6) ◽

pp. 479-491 ◽

Author(s):

W.W.K.R. Mederski ◽

D Dorsch ◽

M Osswald ◽

H Schwartz ◽

N Beier ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00613 ◽

2021 ◽

Author(s):

Andrew K. Dilger ◽

Kumar B. Pabbisetty ◽

James R. Corte ◽

Indawati De Lucca ◽

Tianan Fang ◽

...

Keyword(s):

Clinical Studies ◽

Antithrombotic Therapy ◽

High Affinity ◽

Orally Bioavailable

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High affinity phenylglycinol-based NK 1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(97)10163-9 ◽

1998 ◽

Vol 8 (1) ◽

pp. 51-56 ◽

Author(s):

A.P Owens ◽

T Harrison ◽

J.D Moseley ◽

C.J Swain ◽

S Sadowski ◽

...

Keyword(s):

Receptor Antagonists ◽

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Competitive GABAA receptor antagonists increase the proportion of functional high-affinity α6 subunit-containing receptors in granule cells of adult rat cerebellum

Neuropharmacology ◽

10.1016/s0028-3908(02)00331-3 ◽

2003 ◽

Vol 44 (1) ◽

pp. 56-69 ◽

Author(s):

Mark J Wall

Keyword(s):

Gabaa Receptor ◽

Granule Cells ◽

Receptor Antagonists ◽

Adult Rat ◽

High Affinity ◽

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Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: High affinity and human/rat species-selective histamine H3 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.09.052 ◽

2013 ◽

Vol 23 (23) ◽

pp. 6415-6420 ◽

Author(s):

Shinya Harusawa ◽

Koichi Sawada ◽

Takuji Magata ◽

Hiroki Yoneyama ◽

Lisa Araki ◽

...

Keyword(s):

Receptor Antagonists ◽

Histamine H3 Receptor ◽

High Affinity ◽

H3 Receptor ◽

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Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.09.018 ◽

2004 ◽

Vol 14 (22) ◽

pp. 5481-5484 ◽

Author(s):

Nicholas D. Smith ◽

Steve F. Poon ◽

Dehua Huang ◽

Mitchell Green ◽

Christopher King ◽

...

Keyword(s):

Cytochrome P450 ◽

Inhibitory Activity ◽

Receptor Antagonists ◽

Cytochrome P450 1A2 ◽

Metabotropic Glutamate ◽

Mglu5 Receptor ◽

Orally Bioavailable

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