ChemInform Abstract: Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Nonsteroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2.

ChemInform ◽  
2010 ◽  
Vol 33 (34) ◽  
pp. no-no
Author(s):  
Ola I. A. Salem ◽  
Tobias Schulz ◽  
Rolf W. Hartmann
Keyword(s):  
Benzoic Acid ◽  
Biological Evaluation ◽  
Benzoic Acid Derivatives ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

2007 ◽  
Vol 15 (4) ◽  
pp. 1679-1693 ◽  
Author(s):  
Jun Chiba ◽  
Shin Iimura ◽  
Yoshiyuki Yoneda ◽  
Toshiyuki Watanabe ◽  
Fumito Muro ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Biological Evaluation ◽  
Benzoic Acid Derivatives ◽  
Orally Active ◽  
Synthesis And Biological Evaluation

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 4-[4-Arylpyridin-1(4H)-yl]benzoic Acid Derivatives as Anti-HIV-1 Agents

2017 ◽  
Vol 14 (12) ◽  
pp. e1700295 ◽  
Author(s):  
Saghi Sepehri ◽  
Sepehr Soleymani ◽  
Rezvan Zabihollahi ◽  
Mohammad R. Aghasadeghi ◽  
Mehdi Sadat ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Benzoic Acid ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Molecular Docking Studies ◽  
Benzoic Acid Derivatives ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 666 ◽  
Author(s):  
Katerina Georgousaki ◽  
Nikolaos Tsafantakis ◽  
Sentiljana Gumeni ◽  
George Lambrinidis ◽  
Victor González-Menéndez ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
In Silico ◽  
Functional Module ◽  
Biological Evaluation ◽  
Bjerkandera Adusta ◽  
Benzoic Acid Derivatives ◽  
Human Foreskin Fibroblasts ◽  
In Silico Studies ◽  
Network Modules ◽  
Ubiquitin Proteasome

A main cellular functional module that becomes dysfunctional during aging is the proteostasis network. In the present study, we show that benzoic acid derivatives isolated from Bjerkandera adusta promote the activity of the two main protein degradation systems, namely the ubiquitin-proteasome (UPP) and especially the autophagy-lysosome pathway (ALP) in human foreskin fibroblasts. Our findings were further supported by in silico studies, where all compounds were found to be putative binders of both cathepsins B and L. Among them, compound 3 (3-chloro-4-methoxybenzoic acid) showed the most potent interaction with both enzymes, which justifies the strong activation of cathepsins B and L (467.3 ± 3.9%) on cell-based assays. Considering that the activity of both the UPP and ALP pathways decreases with aging, our results suggest that the hydroxybenzoic acid scaffold could be considered as a promising candidate for the development of novel modulators of the proteostasis network, and likely of anti-aging agents.

scholarly journals Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Vinod Kumar Pandey ◽  
Zehra Tusi ◽  
Sumerah Tusi ◽  
Madhawanand Joshi
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Benzoic Acid ◽  
Carbon Disulphide ◽  
Antiviral Agents ◽  
Biological Evaluation ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus ◽  
Synthesis And Biological Evaluation

A series of novel 4-amino-5-mercapto-3-[(3-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazoles (5a-d) were obtained by treating m-(aralkyl amido/imidoalkyl) benzoic acid hydrazides (3a-d) with carbon disulphide in alcoholic KOH and hydrazine hydrate, respectively. These triazole derivatives were employed in the synthesis of 5-[(3′-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines (6a-d). The newly synthesized compounds were evaluated for their antiviral activity against two animal viruses, namely, Japanese encephalitis virus (JEV) strain P20778 and herpes simplex virus-1 (HSV-1) strain 753166.

scholarly journals Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives

2014 ◽  
Vol 34 ◽  
pp. 48-54
Author(s):  
Hitesh Makwana ◽  
Yogesh T. Naliapara
Keyword(s):  
Antimicrobial Activity ◽  
Nmr Spectroscopy ◽  
Benzoic Acid ◽  
Phosphorus Oxychloride ◽  
13C Nmr Spectroscopy ◽  
Biological Evaluation ◽  
Plate Method ◽  
Benzoic Acid Derivatives ◽  
Oxadiazole Derivatives ◽  
Anti Fungal

We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

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