New Methodology for 2-Alkylation of 3-Furoic Acids: Application to the Synthesis of Tethered UC-781/d4T Bifunctional HIV Reverse-Transcriptase Inhibitors.

ChemInform ◽  
2005 ◽  
Vol 36 (39) ◽  
Author(s):  
Gareth Arnott ◽  
Roger Hunter ◽  
Linda Mbeki ◽  
Ebrahim Mohamed
Keyword(s):  
Reverse Transcriptase ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitors ◽  
Furoic Acids

scholarly journals Fullerene Derivatives of Nucleoside HIV Reverse Transcriptase Inhibitors—In Silico Activity Prediction

2018 ◽  
Vol 19 (10) ◽  
pp. 3231 ◽  
Author(s):  
Aleksandra Dąbrowska ◽  
Tomasz Pieńko ◽  
Przemysław Taciak ◽  
Katarzyna Wiktorska ◽  
Zdzisław Chilmonczyk ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitors ◽  
Activity Prediction ◽  
Hiv Therapy ◽  
C20 Fullerene ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Similar Affinity ◽  
Hiv 1

Here we present new derivatives of nucleoside reverse transcriptase inhibitors with a C20 fullerene. The computational chemistry methods used in this study evaluate affinity of designed compounds towards the HIV-1 reverse transcriptase (RT) binding site and select the most active ones. The best of the designed compounds have superior or similar affinity to RT active site in comparison to most active test compounds, including drugs used in anti-HIV therapy.

scholarly journals Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3350
Author(s):  
Anna A. Maslova ◽  
Elena S. Matyugina ◽  
Robert Snoeck ◽  
Graciela Andrei ◽  
Sergey N. Kochetkov ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Reverse Transcriptase ◽  
Viral Infections ◽  
Virus Infections ◽  
Healthy Individuals ◽  
Type Synthesis ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitors ◽  
New Type ◽  
Nucleoside Inhibitors

Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infections can accelerate the acute phase of HIV infection and AIDS. Thus, the idea of designing compounds that could combine activity against HIV and co-infections would seem promising. In that regard, eleven compounds were synthesized that represent conjugates of non-nucleoside HIV reverse transcriptase inhibitors and nucleoside inhibitors of the herpes family viruses with the hope that these novel heterodimers will result in dual activity against HIV and concomitant herpes virus infections.

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