One-Pot Wittig Reactions in Aqueous Media: A Rapid and Environmentally Benign Synthesis of α,β-Unsaturated Carboxylic Esters and Nitriles.

ChemInform ◽  
2007 ◽  
Vol 38 (9) ◽  
Author(s):  
Jinlong Wu ◽  
Congyong Yue
Keyword(s):  
Aqueous Media ◽  
Environmentally Benign ◽  
One Pot ◽  
Benign Synthesis ◽  
Wittig Reactions ◽  
Carboxylic Esters

scholarly journals Environmentally Benign Synthesis of Tetra-Substituted Imidazoles through 4-Components Strategy Mediated by (S)-3-Methyl-1, 1-Diphenylbutane-1, 2-Diamine

2018 ◽  
Vol 10 (1) ◽  
pp. 39-50
Author(s):  
M. Rana ◽  
A. Rahman ◽  
P. K. Roy ◽  
H. N. Roy
Keyword(s):  
Cost Effectiveness ◽  
Environmentally Benign ◽  
One Pot ◽  
Benign Synthesis

(S)-3-Methyl-1, 1-diphenylbutane-1, 2-diamine has been found to be a mild and effective organocatalyst for one-pot 4-components synthesis of 1, 2, 4, 5-tetra-substituted imidazoles. The key benefits of this protocol is high yielding, cost effectiveness, easy purification and above all, environmentally benign.

Fast and Efficient Green Procedure for the Synthesis of Benzo[5,6]chromene Derivatives and Their Sulfur Analogues in Water by Organocatalyst Potassium Phthalimide-N-oxyl

Synthesis ◽  
2020 ◽  
Vol 52 (11) ◽  
pp. 1707-1718
Author(s):  
Nasser Etivand ◽  
Jabbar Khalafy ◽  
Mohammad G. Dekamin
Keyword(s):  
Aqueous Media ◽  
Thiobarbituric Acid ◽  
Environmentally Benign ◽  
The Novel ◽  
One Pot ◽  
Synthetic Strategy ◽  
Three Component Reaction ◽  
High Yields ◽  
Green Procedure ◽  
Arylglyoxal Monohydrates

A simple, clean, straightforward, and environmentally benign one-pot, three-component reaction of various arylglyoxal monohydrates, β-naphthol, and barbituric acid [pyrimidine-2,4,6(1H,3H,5H)-trione] or thiobarbituric acid in the presence of catalytic amounts potassium phthalimide-N-oxyl (PPINO), as a mild and efficient organocatalyst in aqueous media under reflux conditions is reported. This transformation produced the novel diverse-substituted 12-benzoyl-8,12-dihydro-9H-benzo[5,6]chromeno[2,3-d]pyrimidine-9,11(10H)-diones and their sulfur analogues in 82–93% yield via filtration and without utilization of any chromatography. The high yields of products, very simple operation, easy workup, availability of starting materials, green process, and high atom-economy are the main benefits of this synthetic strategy.

Environmentally benign synthesis of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using CeO2 nanoparticles as a reusable and robust catalyst

2016 ◽  
Vol 71 (11) ◽  
pp. 1135-1140 ◽  
Author(s):  
Javad Safaei-Ghomi ◽  
Mehrnoosh Asgari-Kheirabadi ◽  
Hossein Shahbazi-Alavi
Keyword(s):  
Condensation Reaction ◽  
Ceo2 Nanoparticles ◽  
Environmentally Benign ◽  
High Yield ◽  
Synthesis And Characterization ◽  
Dimethyl Acetylenedicarboxylate ◽  
One Pot ◽  
Efficient Catalyst ◽  
Benign Synthesis

AbstractIn this work, we report the synthesis and characterization of CeO2 nanoparticles as an efficient catalyst for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates via one-pot four-component condensation reaction of dimethyl acetylenedicarboxylate, hydrazine hydrate, malononitrile, and aldehydes in aqueous medium. The use of a non-hazardous organic solvent, easy recovery of the catalyst, compatibility with various functional groups, and high yield of the products make the protocol attractive, greener, and economic.

scholarly journals Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium (III) chloride hydrate as a versatile homogeneous catalyst

2012 ◽  
Vol 77 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Khalil Tabatabaeian ◽  
Hannaneh Heidari ◽  
Alireza Khorshidi ◽  
Manouchehr Mamaghani ◽  
Nosrat Mahmoodi
Keyword(s):  
Michael Reaction ◽  
Aqueous Media ◽  
Environmentally Benign ◽  
Homogeneous Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
The One ◽  
High Yields ◽  
Chloride Hydrate ◽  
Short Times

The one-pot domino Knoevenagel-type condensation/Michael reaction of aromatic, heteroaromatic and aliphatic aldehydes with 4-hydroxycoumarin in aqueous media in the presence of ruthenium salt as homogeneous catalyst was investigated. It was found that 5 mol% of RuCl3.nH2O catalyzes biscoumarin synthesis in high yields (70-95%) under optimised, mild, green and environmentally benign reaction conditions in short times (25-35min).

scholarly journals Ultrasound Promoted Green and Facile One-Pot Multicomponent Synthesis of 3,4-dihydropyrano[c]chromene Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ravikumar Nagalapalli ◽  
Satyanarayana Reddy Jaggavarapu ◽  
Venkata Prasad Jalli ◽  
Anand Solomon Kamalakaran ◽  
Gopikrishna Gaddamanugu
Keyword(s):  
Aqueous Media ◽  
Reaction Times ◽  
Environmentally Benign ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
High Yields

Ultrasound promoted mild one-pot multicomponent synthesis of 3,4-dihydropyrano[c]chromenes from 4-hydroxycoumarin, arylaldehydes and malononitrile was achieved in aqueous media. The methodology promises advantages of short reaction times, environmentally benign conditions, high yields, and operational convenience.

scholarly journals Chemoenzymatic one-pot reaction of noncompatible catalysts: combining enzymatic ester hydrolysis with Cu(i)/bipyridine catalyzed oxidation in aqueous medium

RSC Advances ◽  
2017 ◽  
Vol 7 (53) ◽  
pp. 33614-33626 ◽  
Author(s):  
Henning Sand ◽  
Ralf Weberskirch
Keyword(s):  
Aqueous Medium ◽  
Ester Hydrolysis ◽  
Environmentally Benign ◽  
One Pot ◽  
Benign Synthesis ◽  
Catalyzed Oxidation

Combination of a lipase (CALB) with a Cu/bipyridine catalyst for environmentally benign synthesis of aldehydes from their corresponding esters.

Potassium phthalimide-catalysed one-pot multi-component reaction for efficient synthesis of amino-benzochromenes in aqueous media

2014 ◽  
Vol 68 (8) ◽  
Author(s):  
Hamzeh Kiyani ◽  
Fatemeh Ghorbani
Keyword(s):  
Organic Solvent ◽  
Aqueous Media ◽  
Ethyl Cyanoacetate ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
High Yields

Abstract2-Amino-4-aryl-4H-benzo[h]chromenes and 3-amino-1-aryl-1H-benzo[f]chromenes were prepared by treating cyano-methylene compounds (malononitrile or ethyl cyanoacetate), substituted aromatic aldehydes, and naphtholic compounds in the presence of potassium phthalimide as a green, mild, efficient, and commercially available organocatalyst in aqueous media. The procedure was readily conducted and affords remarkable advantages such as safety, short reaction times, environmentally benign milder reaction conditions, no organic solvent required, and high yields.

Environmentally Benign Synthesis of Isoflavone Derivatives Using Polymer-Supported Hypervalent Iodine(III) Reagent

2003 ◽  
Vol 17 (08n09) ◽  
pp. 1482-1486 ◽  
Author(s):  
Yasuhiko Kawamura ◽  
Masashi Maruyama ◽  
Kazuyo Yamashita ◽  
Masao Tsukayama
Keyword(s):  
Environmentally Benign ◽  
Hypervalent Iodine ◽  
One Pot ◽  
Toluenesulfonic Acid ◽  
Benign Synthesis ◽  
Polymer Supported ◽  
Koser's Reagent

Isoflavones are synthesized in one-pot manner by action of a hypervalent iodine (III) reagent, ⌊hydroxy(tosyloxy)iodo⌋benzene (HTIB, Koser's reagent) on 2'-benzoyloxychalcones in MeOH. A combined usage of iodobenzene diacetate (IBD)—p-toluenesulfonic acid (TsOH) is also effective for the same purpose. As an extension of those monomeric reagents, polymer-supported IBD (PSIBD, poly ⌊4-(diacetoxy)iodo⌋styrene) with TsOH works also well with merit of easy separation of isoflavones from the reaction mixture, no liberation of PhI, and reuse of the reagent.

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