Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

: Tanshinones are a class of bioactive compounds present in the Chinese herbal medicine Danshen (Salvia miltiorrhiza Bunge), containing among others, abietane diterpene quinone scaffolds. Chemical synthesis and biological activity studies of natural and unnatural tanshinone derivatives have been reviewed in this article.

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Enantioselective Catalytic C-H Amidations: An Highlight

Catalysts ◽

10.3390/catal11040471 ◽

2021 ◽

Vol 11 (4) ◽

pp. 471

Author(s):

Eleonora Tosi ◽

Renata Marcia de Figueiredo ◽

Jean-Marc Campagne

Keyword(s):

Biological Activity ◽

Chemical Synthesis ◽

Crucial Role ◽

Medicinal Chemistry ◽

Life Sciences ◽

Biological Processes ◽

Chiral Molecules ◽

Material Sciences ◽

Innovative Approaches

The crucial role played by compounds bearing amide functions, not only in biological processes but also in several fields of chemistry, life polymers and material sciences, has brought about many significant discoveries and innovative approaches for their chemical synthesis. Indeed, a plethora of strategies has been developed to reach such moieties. Amides within chiral molecules are often associated with biological activity especially in life sciences and medicinal chemistry. In most of these cases, their synthesis requires extensive rethinking methodologies. In the very last years (2019–2020), enantioselective C-H functionalization has appeared as a straightforward alternative to reach chiral amides. Therein, an overview on these transformations within this timeframe is going to be given.

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Cordycepin analogues of 2-5A and its derivatives. Chemical synthesis and biological activity.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)33038-2 ◽

1983 ◽

Vol 258 (3) ◽

pp. 1671-1677

Author(s):

H Sawai ◽

J Imai ◽

K Lesiak ◽

M I Johnston ◽

P F Torrence

Keyword(s):

Biological Activity ◽

Chemical Synthesis

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The cyclic diguanylic acid regulatory system of cellulose synthesis in Acetobacter xylinum. Chemical synthesis and biological activity of cyclic nucleotide dimer, trimer, and phosphothioate derivatives.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)30606-3 ◽

1990 ◽

Vol 265 (31) ◽

pp. 18933-18943 ◽

Cited By ~ 1

Author(s):

P Ross ◽

R Mayer ◽

H Weinhouse ◽

D Amikam ◽

Y Huggirat ◽

...

Keyword(s):

Biological Activity ◽

Chemical Synthesis ◽

Cyclic Nucleotide ◽

Regulatory System ◽

Acetobacter Xylinum ◽

Cellulose Synthesis

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Chemical Reactivity and Biological Activity of Diketene

Chemical Research in Toxicology ◽

10.1021/tx800153j ◽

2008 ◽

Vol 21 (10) ◽

pp. 1964-1969 ◽

Cited By ~ 18

Author(s):

Rafael Gómez-Bombarelli ◽

Marina González-Pérez ◽

M. Teresa Pérez-Prior ◽

José A. Manso ◽

Emilio Calle ◽

...

Keyword(s):

Biological Activity ◽

Chemical Reactivity

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The Chemistry and Biological Activity of Acyl Glucuronides

ChemInform ◽

10.1002/chin.200728207 ◽

2007 ◽

Vol 38 (28) ◽

Author(s):

Andrew V. Stachulski

Keyword(s):

Biological Activity ◽

Acyl Glucuronides

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Chemical synthesis of a very long oligoribonucleotide with 2-cyanoethoxymethyl (CEM) as the 2′-O-protecting group: structural identification and biological activity of a synthetic 110mer precursor-microRNA candidate

Nucleic Acids Research ◽

10.1093/nar/gkm202 ◽

2007 ◽

Vol 35 (10) ◽

pp. 3287-3296 ◽

Cited By ~ 58

Author(s):

Yoshinobu Shiba ◽

Hirofumi Masuda ◽

Naoki Watanabe ◽

Takeshi Ego ◽

Kazuchika Takagaki ◽

...

Keyword(s):

Biological Activity ◽

Chemical Synthesis ◽

Structural Identification ◽

Protecting Group

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A Computational Approach on Acetaminophen Drug using Degree-Based Topological Indices and M-Polynomials

Biointerface Research in Applied Chemistry ◽

10.33263/briac126.72497266 ◽

2021 ◽

Vol 12 (6) ◽

pp. 7249-7266

Keyword(s):

Biological Activity ◽

Physicochemical Properties ◽

Chemical Structure ◽

Topological Index ◽

Chemical Reactivity ◽

Chemical Compounds ◽

Computational Approach ◽

Topological Indices ◽

Numerical Representation ◽

Essential Drug

Topological index is a numerical representation of a chemical structure. Based on these indices, physicochemical properties, thermodynamic behavior, chemical reactivity, and biological activity of chemical compounds are calculated. Acetaminophen is an essential drug to prevent/treat various types of viral fever, including malaria, flu, dengue, SARS, and even COVID-19. This paper computes the sum and multiplicative version of various topological indices such as General Zagreb, General Randić, General OGA, AG, ISI, SDD, Forgotten indices M-polynomials of Acetaminophen. To the best of our knowledge, for the Acetaminophen drugs, these indices have not been computed previously.

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