Synthesis and Biological Activity Study of Tanshinone Derivatives: A Literature and Patent Review

2020 ◽  
Vol 20 (28) ◽  
pp. 2520-2534
Author(s):  
He Huang ◽  
Chuanjun Song ◽  
Junbiao Chang
Keyword(s):  
Biological Activity ◽  
Herbal Medicine ◽  
Chemical Synthesis ◽  
Bioactive Compounds ◽  
Chinese Herbal Medicine ◽  
Salvia Miltiorrhiza ◽  
Salvia Miltiorrhiza Bunge ◽  
Chinese Herbal ◽  
Patent Review

: Tanshinones are a class of bioactive compounds present in the Chinese herbal medicine Danshen (Salvia miltiorrhiza Bunge), containing among others, abietane diterpene quinone scaffolds. Chemical synthesis and biological activity studies of natural and unnatural tanshinone derivatives have been reviewed in this article.

scholarly journals Complementary Chinese Herbal Medicine Therapy Improves Survival in Patients With Pemphigus: A Retrospective Study From a Taiwan-Based Registry

2020 ◽  
Vol 11 ◽  
Author(s):  
Po-Yuan Wu ◽  
Te-Mao Li ◽  
Shu-I. Chen ◽  
Chao-Jung Chen ◽  
Jian-Shiun Chiou ◽  
...  
Keyword(s):  
Overall Survival ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Salvia Miltiorrhiza ◽  
Rank Test ◽  
Lycium Barbarum ◽  
Radix Salviae Miltiorrhizae ◽  
Chinese Herbal ◽  
Forsythia Suspensa ◽  
Overall Mortality

Pemphigus is a life-threatening and skin-specific inflammatory autoimmune disease, characterized by intraepidermal blistering between the mucous membranes and skin. Chinese herbal medicine (CHM) has been used as an adjunct therapy for treating many diseases, including pemphigus. However, there are still limited studies in effects of CHM treatment in pemphigus, especially in Taiwan. To more comprehensively explore the effect of long-term CHM treatment on the overall mortality of pemphigus patients, we performed a retrospective analysis of 1,037 pemphigus patients identified from the Registry for Catastrophic Illness Patients database in Taiwan. Among them, 229 and 177 patients were defined as CHM users and non-users, respectively. CHM users were young, predominantly female, and had a lesser Charlson comorbidity index (CCI) than non-CHM users. After adjusting for age, sex, prednisolone use, and CCI, CHM users had a lower overall mortality risk than non-CHM users (multivariate model: hazard ratio (HR): 0.422, 95% confidence interval (CI): 0.242–0.735, p = 0.0023). The cumulative incidence of overall survival was significantly higher in CHM users than in non-users (p = 0.0025, log rank test). Association rule mining and network analysis showed that there was one main CHM cluster with Qi–Ju–Di–Huang–Wan (QJDHW), Dan–Shen (DanS; Radix Salviae miltiorrhizae; Salvia miltiorrhiza Bunge), Jia–Wei–Xiao–Yao-–San (JWXYS), Huang–Lian (HL; Rhizoma coptidis; Coptis chinensis Franch.), and Di–Gu–Pi (DGP; Cortex lycii; Lycium barbarum L.), while the second CHM cluster included Jin–Yin–Hua (JYH; Flos lonicerae; Lonicera hypoglauca Miq.) and Lian–Qiao (LQ; Fructus forsythiae; Forsythia suspensa (Thunb.) Vahl). In Taiwan, CHMs used as an adjunctive therapy reduced the overall mortality to approximately 20% among pemphigus patients after a follow-up of more than 6 years. A comprehensive CHM list may be useful in future clinical trials and further scientific investigations to improve the overall survival in these patients.

scholarly journals Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan

2021 ◽  
Vol 12 ◽  
Author(s):  
Mu-Lin Chiu ◽  
Yu-Lung Hsu ◽  
Chao-Jung Chen ◽  
Te-Mao Li ◽  
Jian-Shiun Chiou ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Aplastic Anemia ◽  
Chinese Herbal Medicine ◽  
Large Scale ◽  
Salvia Miltiorrhiza ◽  
Bone Marrow Failure ◽  
Complementary Therapy ◽  
Population Based ◽  
Chinese Herbal ◽  
Kaplan Meier

Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) is beneficial to AA patients as a complementary therapy using a nationwide population-based database in Taiwan between 2000–2016. Patient survival was estimated by Kaplan‒Meier survival analyses and Cox proportional-hazard model. CHM-users presented lower risks of overall and anemia-related mortalities when compared to non-users. The risk of overall mortality for CHM-users in AA patients was 0.70-fold [adjusted hazard ratio (aHR): 0.70, 95% confidence interval (CI): 0.66-0.74, p < 0.001). The risk of anemia-related mortality was lower in CHM-users when compared to non-users (aHR: 0.46, 95% CI: 0.32-0.67, p < 0.001). The association rule analysis revealed that CHM pairs were Ban-Zhi-Lian (BZL; Scutellaria barbata D. Don)→Bai-Hua-She-She-Cao (BHSSC; Oldenlandia diffusa (Willd.) Roxb.), followed by Dang-Gui (DG; Angelica sinensis (Oliv.) Diels)→Huang-Qi (HQi; Astragalus membranaceus (Fisch.) Bunge), and Xian-He-Cao (XHC; Agrimonia pilosa f. borealis (Kitag.) Chu)→Gui-Pi-Tang (GPT). Network analysis showed that BZL, BHSSC, DG, HQi, XHC, GPT, and Dan-Shen (DanS; Salvia miltiorrhiza var. charbonnelii (H.Lév.) C.Y.Wu) were commonly used CHMs for AA patients. Therefore, further studies for these commonly prescribed herbs are needed in functional investigations in hematopoiesis-stimulating effect and large-scale randomized controlled trials (RCT) in bone marrow failure related diseases.

scholarly journals Improved Survival With Integration of Chinese Herbal Medicine Therapy in Patients With Acute Myeloid Leukemia: A Nationwide Population-Based Cohort Study

2016 ◽  
Vol 16 (2) ◽  
pp. 156-164 ◽  
Author(s):  
Tom Fleischer ◽  
Tung-Ti Chang ◽  
Jen-Huai Chiang ◽  
Mao-Feng Sun ◽  
Hung-Rong Yen
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cohort Study ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Myeloid Leukemia ◽  
Salvia Miltiorrhiza ◽  
Population Based ◽  
Research Database ◽  
Chinese Herbal ◽  
Acute Myeloid

Purpose. Acute myeloid leukemia (AML) is the most deadly subtype of leukemia, and many patients with this disease seek other complementary therapies, one of which is Chinese medicine. We set out to provide reliable data regarding the benefit of Chinese herbal medicine (CHM) for AML patients, using mortality as the main outcome measure. We also characterized the herbal prescriptions of patients. Methods. Using the Taiwanese National Health Insurance Research Database, we performed a nationwide population-based cohort study among AML patients from 1997 to 2010. The Cox regression model was used to adjust for comorbidities and other variables, and the hazard ratios (HRs) of CHM users and non–CHM users were compared. Results. After 1:1 matching, 498 patients were included into the study. The HR of the CHM group was 0.41 (95% CI = 0.26-0.65; P = .0001) compared with the non-CHM group. This decrease in HR was also shown to be dose dependent ( P < .001). The 3 single-herbs most commonly prescribed were Salvia miltiorrhiza (Dan Shen), Astragalus membranaceus (Huang Qi), and Spatholobus suberectus (Ji Xue Teng). The 3 mutli-herb products most commonly prescribed were Jia Wei Xiao Yao San, Gui Pi Tang, and Qi Ju Di Huang Wan. Conclusion. Prospective controlled clinical data is still needed, however, this study provides real-world data regarding the benefit AML patients may have from CHM. This study suggests that all AML patients, regardless of age or other prognostic factors, may achieve longer survival times when receiving CHM in addition to standard therapy.

Application of Traditional Chinese Herbal Medicine By-products as Dietary Feed Supplements and Antibiotic Replacements in Animal Production

2019 ◽  
Vol 20 (1) ◽  
pp. 54-64 ◽  
Author(s):  
Abedin Abdallah ◽  
Pei Zhang ◽  
Qingzhen Zhong ◽  
Zewei Sun
Keyword(s):  
Herbal Medicine ◽  
Bioactive Compounds ◽  
Chinese Herbal Medicine ◽  
Experimental Studies ◽  
Animal Production ◽  
Feed Additives ◽  
Farm Animals ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
By Products

Background: Misuse of synthetic antibiotics in livestock leads to the transfer of antibiotic resistant pathogens into humans and deposits toxic residues in meat and milk. There is therefore an urgent need for safe and viable alternative approaches to improve the nutrition and wellbeing of farm animals. An alternative source that has been widely exploited is Traditional Chinese Herbal Medicine (TCHM). These herbs contain several but less toxic bioactive compounds which are generally regarded as biodegradable. Recently, advances in the knowledge of the importance of TCHM have led to a rapid increase in its production and hence, increasing the amount of by-products generated. Such by-products have become a serious environmental challenge because producers regard them as industrial waste and discard them directly. This review summarizes scientific findings on the bioactive compounds in TCHM and TCHM by-products, discusses functional dietary patterns and outlines challenges that may hinder full utilization of TCHM by-products in animal production. Methods: Information for this review was obtained through scientific databases and websites such as Pubmed and Google scholar from 2004 to 2017 using experimental studies on bioactive compounds in TCHM and their effects in animal production. Results: Studies have shown that TCHM by-products contain high amounts of bioactive compounds which confer several nutritional and health benefits to animals and thus could be incorporated as feed additives. Conclusion: The findings for this review indicate that TCHM by-products apart from being a good alternative for synthetic antibiotics could also minimize the current environmental challenges associated with its disposal.

Salvia miltiorrhiza: An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs

2014 ◽  
Vol 155 (3) ◽  
pp. 1401-1416 ◽  
Author(s):  
Yubo Guo ◽  
Yu Li ◽  
Liming Xue ◽  
Richele P. Severino ◽  
Sihua Gao ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Salvia Miltiorrhiza ◽  
Chinese Herbal

scholarly journals Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Jindong Zhao ◽  
Yan Li ◽  
Ling Xin ◽  
Min Sun ◽  
Chanjuan Yu ◽  
...  
Keyword(s):  
Data Mining ◽  
Peripheral Neuropathy ◽  
Herbal Medicine ◽  
Clinical Features ◽  
Chinese Herbal Medicine ◽  
Diabetic Peripheral Neuropathy ◽  
Salvia Miltiorrhiza ◽  
Astragalus Membranaceus ◽  
Poria Cocos ◽  
Chinese Herbal

Objective. To analyse the clinical features of diabetic peripheral neuropathy (DPN) and employ data mining technology to explore the rules of Chinese herbal medicine (CHM) therapy. Methods. The clinical data of 216 patients with DPN and qi-yin deficiency syndrome were obtained, and the clinical features of the patients were assessed by cluster analysis. Relevant information was entered into the clinical diagnosis and treatment collection system, and data mining techniques were used to analyse the drug frequency, core CHM, CHM pair, and so on. Results. In this study, glycated haemoglobin (HbA1c) and homocysteine (HCY) were closely related to the pathogenesis of DPN. Overall, 162 patients had typical DPN syndrome characteristics, and we analysed 216 prescriptions, including 182 CHM. The frequencies of prescription of Astragalus membranaceus, Ligusticum wallichii, Poria cocos, and Radix Rehmanniae were greater than 45%. A Bayesian network analysis diagram showed that the 9 most common core CHM included Astragalus membranaceus, Ligusticum wallichii, Poria cocos, atractylodes rhizome, and Salvia miltiorrhiza Bge. According to the association rules of CHM, Radix Ophiopogon is used for Codonopsis pilosula; Astragalus membranaceus and atractylodes rhizome for Rehmannia are also frequently used. Astragalus membranaceus and Cinnamomi Ramulus or Ligusticum wallichii and Moutan bark were highly related to a decreased Michigan Diabetic Neuropathy Score. Conclusion. HbA1c and HCY are related risk factors for DPN. Numbness is a typical syndrome characteristic. Astragalus membranaceus is a monarch CHM and is used most frequently.

The effect of the chinese herbal medicine Dai-Kenchu-To on intestinal blood flow

2001 ◽  
Vol 120 (5) ◽  
pp. A248-A248
Author(s):  
N KAWASAKI ◽  
K NARIAI ◽  
M NAKAO ◽  
K NAKADA ◽  
N HANYUU ◽  
...  
Keyword(s):  
Blood Flow ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Intestinal Blood Flow ◽  
Chinese Herbal
Sign in / Sign up

Export Citation Format

Share Document